5WIK

JAK2 Pseudokinase in complex with BI-D1870

Summary for 5WIK

• Entry DOI: 10.2210/pdb5wik/pdb
• Descriptor: Tyrosine-protein kinase JAK2, (7R)-2-[(3,5-difluoro-4-hydroxyphenyl)amino]-5,7-dimethyl-8-(3-methylbutyl)-7,8-dihydropteridin-6(5H)-one (3 entities in total)
• Functional Keywords: jak2, pseudokinase, bi-d1870, transferase
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 1
• Total formula weight: 32072.78

Authors

Li, Q.,Eck, M.J.,Li, K.,Park, E. (deposition date: 2017-07-19, release date: 2018-08-01, Last modification date: 2024-03-13)

• Primary citation: McNally, R.,Li, Q.,Li, K.,Dekker, C.,Vangrevelinghe, E.,Jones, M.,Chene, P.,Machauer, R.,Radimerski, T.,Eck, M.J.; Discovery and Structural Characterization of ATP-Site Ligands for the Wild-Type and V617F Mutant JAK2 Pseudokinase Domain.; ACS Chem. Biol., 14:587-593, 2019; PubMed: 30763067; DOI: 10.1021/acschembio.8b00722

Experimental method

X-RAY DIFFRACTION (2.6 Å)