5WI6

Human beta-1 tryptase mutant Ile99Cys

Summary for 5WI6

Entry DOI	10.2210/pdb5wi6/pdb
Related PRD ID	PRD_000288
Descriptor	Tryptase alpha/beta-1, SULFATE ION, L-alpha-glutamyl-N-{(1S)-4-{[amino(iminio)methyl]amino}-1-[(1S)-2-chloro-1-hydroxyethyl]butyl}glycinamide, ... (4 entities in total)
Functional Keywords	disulfide mutation, hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological source	Homo sapiens (Human)
Total number of polymer chains	4
Total formula weight	112121.23
Authors	Eigenbrot, C.,Maun, H.R. (deposition date: 2017-07-18, release date: 2018-04-25, Last modification date: 2023-10-04)
Primary citation	Maun, H.R.,Liu, P.S.,Franke, Y.,Eigenbrot, C.,Forrest, W.F.,Schwartz, L.B.,Lazarus, R.A. Dual functionality of beta-tryptase protomers as both proteases and cofactors in the active tetramer. J. Biol. Chem., 293:9614-9628, 2018 Cited by PubMed: 29661938 DOI: 10.1074/jbc.M117.812016 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.72 Å)

Structure validation