5WI6

Human beta-1 tryptase mutant Ile99Cys

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004252	molecular_function	serine-type endopeptidase activity
A	0005515	molecular_function	protein binding
A	0005576	cellular_component	extracellular region
A	0005615	cellular_component	extracellular space
A	0006508	biological_process	proteolysis
A	0006952	biological_process	defense response
A	0008233	molecular_function	peptidase activity
A	0008236	molecular_function	serine-type peptidase activity
A	0016787	molecular_function	hydrolase activity
A	0022617	biological_process	extracellular matrix disassembly
A	0031012	cellular_component	extracellular matrix
A	0042802	molecular_function	identical protein binding
B	0004252	molecular_function	serine-type endopeptidase activity
B	0005515	molecular_function	protein binding
B	0005576	cellular_component	extracellular region
B	0005615	cellular_component	extracellular space
B	0006508	biological_process	proteolysis
B	0006952	biological_process	defense response
B	0008233	molecular_function	peptidase activity
B	0008236	molecular_function	serine-type peptidase activity
B	0016787	molecular_function	hydrolase activity
B	0022617	biological_process	extracellular matrix disassembly
B	0031012	cellular_component	extracellular matrix
B	0042802	molecular_function	identical protein binding
C	0004252	molecular_function	serine-type endopeptidase activity
C	0005515	molecular_function	protein binding
C	0005576	cellular_component	extracellular region
C	0005615	cellular_component	extracellular space
C	0006508	biological_process	proteolysis
C	0006952	biological_process	defense response
C	0008233	molecular_function	peptidase activity
C	0008236	molecular_function	serine-type peptidase activity
C	0016787	molecular_function	hydrolase activity
C	0022617	biological_process	extracellular matrix disassembly
C	0031012	cellular_component	extracellular matrix
C	0042802	molecular_function	identical protein binding
D	0004252	molecular_function	serine-type endopeptidase activity
D	0005515	molecular_function	protein binding
D	0005576	cellular_component	extracellular region
D	0005615	cellular_component	extracellular space
D	0006508	biological_process	proteolysis
D	0006952	biological_process	defense response
D	0008233	molecular_function	peptidase activity
D	0008236	molecular_function	serine-type peptidase activity
D	0016787	molecular_function	hydrolase activity
D	0022617	biological_process	extracellular matrix disassembly
D	0031012	cellular_component	extracellular matrix
D	0042802	molecular_function	identical protein binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	binding site for residue SO4 A 301

Chain	Residue
A	ARG24
A	GLN71
A	TYR75
A	GLN79

---

site_id	AC2
Number of Residues	10
Details	binding site for residue 0GJ A 302

Chain	Residue
A	TRP215
A	GLY216
A	GLU217
A	GLY219
A	GLY226
A	GLN98
A	ASP189
A	CYS191
A	GLN192
A	GLY193

---

site_id	AC3
Number of Residues	4
Details	binding site for residue SO4 B 301

Chain	Residue
A	TYR75
B	ARG24
B	GLN71
B	GLN79

---

site_id	AC4
Number of Residues	10
Details	binding site for residue 0GJ B 302

Chain	Residue
B	GLN98
B	ASP189
B	CYS191
B	GLN192
B	GLY193
B	TRP215
B	GLY216
B	GLU217
B	GLY219
B	GLY226

---

site_id	AC5
Number of Residues	3
Details	binding site for residue SO4 C 301

Chain	Residue
C	LYS26
C	LYS202
C	TRP207

---

site_id	AC6
Number of Residues	4
Details	binding site for residue SO4 C 302

Chain	Residue
C	ARG24
C	GLN71
C	TYR75
C	GLN79

---

site_id	AC7
Number of Residues	9
Details	binding site for residue 0GJ C 303

Chain	Residue
C	GLN98
C	ASP189
C	CYS191
C	GLN192
C	GLY193
C	TRP215
C	GLY216
C	GLY219
C	GLY226

---

site_id	AC8
Number of Residues	7
Details	binding site for residue SO4 D 301

Chain	Residue
D	GLY19
D	GLN20
D	TRP137
D	GLN157
D	VAL158
D	LYS159
D	ARG188

---

site_id	AC9
Number of Residues	5
Details	binding site for residue SO4 D 302

Chain	Residue
C	TYR75
D	ARG24
D	GLU70
D	GLN71
D	GLN79

---

site_id	AD1
Number of Residues	2
Details	binding site for residue SO4 D 303

Chain	Residue
D	LYS202
D	TRP207

---

site_id	AD2
Number of Residues	9
Details	binding site for residue 0GJ D 304

Chain	Residue
D	GLN98
D	ASP189
D	CYS191
D	GLN192
D	GLY193
D	TRP215
D	GLY216
D	GLY219
D	GLY226

---

Functional Information from PROSITE/UniProt

site_id	PS00134
Number of Residues	6
Details	TRYPSIN_HIS Serine proteases, trypsin family, histidine active site. LTAAHC

Chain	Residue	Details
A	LEU53-CYS58

---

site_id	PS00135
Number of Residues	12
Details	TRYPSIN_SER Serine proteases, trypsin family, serine active site. DScqGDSGGPLV

Chain	Residue	Details
A	ASP189-VAL200

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	964
Details	Domain: {"description":"Peptidase S1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00274","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	12
Details	Active site: {"description":"Charge relay system"}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	4
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	4
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"19159218","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---