8QSQ
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6ORQ
| Modified BG505 SOSIP-based immunogen RC1 in complex with the elicited V3-glycan patch antibody Ab275MUR | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Ab275MUR antibody Fab heavy chain, ... | 著者 | Abernathy, M.E, Gristick, H.B, Bjorkman, P.J. | 登録日 | 2019-04-30 | 公開日 | 2019-06-12 | 最終更新日 | 2020-07-29 | 実験手法 | ELECTRON MICROSCOPY (4.4 Å) | 主引用文献 | Immunization expands B cells specific to HIV-1 V3 glycan in mice and macaques. Nature, 570, 2019
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6ZNL
| Cryo-EM structure of the dynactin complex | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, ARP1 actin related protein 1 homolog A, ... | 著者 | Lau, C.K, Lacey, S.E, Carter, A.P. | 登録日 | 2020-07-06 | 公開日 | 2020-07-29 | 最終更新日 | 2024-05-01 | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | 主引用文献 | Cryo-EM reveals the complex architecture of dynactin's shoulder region and pointed end. Embo J., 40, 2021
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8BEB
| Ternary complex between VCB, BRD4-BD1 and PROTAC 49 | 分子名称: | (2~{S},4~{R})-~{N}-[(1~{S})-3-[4-[2-[(9~{S})-7-(4-chlorophenyl)-4,5,13-trimethyl-3-thia-1,8,11,12-tetrazatricyclo[8.3.0.0^{2,6}]trideca-2(6),4,7,10,12-pentaen-9-yl]ethanoylamino]butylamino]-1-[4-(4-methyl-1,3-thiazol-5-yl)phenyl]-3-oxidanylidene-propyl]-1-[(2~{R})-3-methyl-2-(3-methyl-1,2-oxazol-5-yl)butanoyl]-4-oxidanyl-pyrrolidine-2-carboxamide, Bromodomain-containing protein 4, Elongin-B, ... | 著者 | Sorrell, F.J, Mueller, J.E, Lehmann, M, Wegener, A. | 登録日 | 2022-10-21 | 公開日 | 2023-02-15 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (3.18 Å) | 主引用文献 | Systematic Potency and Property Assessment of VHL Ligands and Implications on PROTAC Design. Chemmedchem, 18, 2023
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8BDT
| Ternary complex between VCB, BRD4-BD2 and PROTAC 51 | 分子名称: | (2~{S},4~{R})-~{N}-[(1~{S})-3-[2-[2-[2-[2-[2-[(9~{S})-7-(4-chlorophenyl)-4,5,13-trimethyl-3-thia-1,8,11,12-tetrazatricyclo[8.3.0.0^{2,6}]trideca-2(6),4,7,10,12-pentaen-9-yl]ethanoylamino]ethoxy]ethoxy]ethoxy]ethylamino]-1-[4-(4-methyl-1,3-thiazol-5-yl)phenyl]-3-oxidanylidene-propyl]-1-[(2~{R})-3-methyl-2-(3-methyl-1,2-oxazol-5-yl)butanoyl]-4-oxidanyl-pyrrolidine-2-carboxamide, Bromodomain-containing protein 4, Elongin-B, ... | 著者 | Sorrell, F.J, Mueller, J.E, Lehmann, M, Wegener, A.A. | 登録日 | 2022-10-20 | 公開日 | 2023-02-15 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Systematic Potency and Property Assessment of VHL Ligands and Implications on PROTAC Design. Chemmedchem, 18, 2023
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6ZSO
| Solution structure of the water-soluble LU-domain of human Lypd6b protein | 分子名称: | Ly6/PLAUR domain-containing protein 6B | 著者 | Tsarev, A.V, Kulbatskii, D.S, Paramonov, A.S, Lyukmanova, E.N, Shenkarev, Z.O. | 登録日 | 2020-07-16 | 公開日 | 2021-01-13 | 実験手法 | SOLUTION NMR | 主引用文献 | Structural Diversity and Dynamics of Human Three-Finger Proteins Acting on Nicotinic Acetylcholine Receptors. Int J Mol Sci, 21, 2020
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6OGI
| 70S termination complex with RF2 bound to the UAG codon. Rotated ribosome conformation (Structure V) | 分子名称: | 16S ribosomal RNA, 23S ribosomal RNA, 30S ribosomal protein S10, ... | 著者 | Svidritskiy, E, Demo, G, Loveland, A.B, Xu, C, Korostelev, A.A. | 登録日 | 2019-04-02 | 公開日 | 2019-09-25 | 最終更新日 | 2024-03-20 | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | 主引用文献 | Extensive ribosome and RF2 rearrangements during translation termination. Elife, 8, 2019
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8BDX
| Ternary complex between VCB, BRD4-BD2 and PROTAC 48 | 分子名称: | (2S,4R)-N-[(1S)-1-(4-chlorophenyl)-3-[2-[2-[2-[2-[2-[(9S)-7-(4-chlorophenyl)-4,5,13-trimethyl-3-thia-1,8$l^{5},11,12-tetrazatricyclo[8.3.0.0^{2,6}]trideca-2(6),4,7,10,12-pentaen-9-yl]ethanoylamino]ethoxy]ethoxy]ethoxy]ethylamino]-3-oxidanylidene-propyl]-1-[(2R)-3-methyl-2-(3-methyl-1,2-oxazol-5-yl)butanoyl]-4-oxidanyl-pyrrolidine-2-carboxamide, Bromodomain-containing protein 4, Elongin-B, ... | 著者 | Sorrell, F.J, Mueller, J.E, Lehmann, M, Wegener, A. | 登録日 | 2022-10-20 | 公開日 | 2023-02-15 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (2.93 Å) | 主引用文献 | Systematic Potency and Property Assessment of VHL Ligands and Implications on PROTAC Design. Chemmedchem, 18, 2023
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8QU9
| Structure of the NCOA4 (Nuclear Receptor Coactivator 4)-FTH1 (H-Ferritin) complex | 分子名称: | FE (III) ION, Ferritin heavy chain, NCOA4 (Nuclear Receptor Coactivator 4) | 著者 | Hoelzgen, F, Klukin, E, Zalk, R, Shahar, A, Cohen-Schwartz, S, Frank, G.A. | 登録日 | 2023-10-15 | 公開日 | 2024-05-15 | 実験手法 | ELECTRON MICROSCOPY (2.88 Å) | 主引用文献 | Structural basis for the intracellular regulation of ferritin degradation. Nat Commun, 15, 2024
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6OI2
| Crystal structure of human WDR5 in complex with symmetric dimethyl-L-arginine | 分子名称: | GLYCEROL, N3, N4-DIMETHYLARGININE, ... | 著者 | Lorton, B.M, Harijan, R.K, Burgos, E, Bonanno, J.B, Almo, S.C, Shechter, D. | 登録日 | 2019-04-08 | 公開日 | 2020-04-01 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (1.68 Å) | 主引用文献 | A Binary Arginine Methylation Switch on Histone H3 Arginine 2 Regulates Its Interaction with WDR5. Biochemistry, 59, 2020
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8QZ2
| Crystal structure of human two pore domain potassium ion channel TREK-2 (K2P10.1) in complex with an inhibitory nanobody (Nb61) | 分子名称: | Nanobody 61, POTASSIUM ION, Potassium channel subfamily K member 10 | 著者 | Baronina, A, Pike, A.C.W, Rodstrom, K.E.J, Ang, J, Bushell, S.R, Chalk, R, Mukhopadhyay, S.M.M, Pardon, E, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Burgess-Brown, N.A, Tucker, S.J, Steyaert, J, Carpenter, E.P, Structural Genomics Consortium (SGC) | 登録日 | 2023-10-26 | 公開日 | 2024-05-29 | 実験手法 | X-RAY DIFFRACTION (3.5 Å) | 主引用文献 | Extracellular modulation of TREK-2 activity with nanobodies provides insight into the mechanisms of K2P channel regulation. Nat Commun, 15, 2024
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6ONS
| Crystal structure of Desulfovibrio vulgaris carbon monoxide dehydrogenase with the D-cluster ligating cysteines mutated to alanines, coexpressed with CooC, as-isolated | 分子名称: | Carbon monoxide dehydrogenase, FE(4)-NI(1)-S(4) CLUSTER, IRON/SULFUR CLUSTER | 著者 | Cohen, S.E, Wittenborn, E.C, Drennan, C.L. | 登録日 | 2019-04-22 | 公開日 | 2019-07-24 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.485 Å) | 主引用文献 | Structural insight into metallocofactor maturation in carbon monoxide dehydrogenase. J.Biol.Chem., 294, 2019
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8BDJ
| VCB in complex with compound 30 | 分子名称: | (2~{S},4~{R})-~{N}-[(1~{S})-1-[4-chloranyl-2-(2-methoxyethoxy)phenyl]ethyl]-1-[(2~{R})-3-methyl-2-(3-methyl-1,2-oxazol-5-yl)butanoyl]-4-oxidanyl-pyrrolidine-2-carboxamide, Elongin-B, Elongin-C, ... | 著者 | Sorrell, F.J, Mueller, J.E, Lehmann, M, Wegener, A. | 登録日 | 2022-10-19 | 公開日 | 2023-02-15 | 最終更新日 | 2024-10-09 | 実験手法 | X-RAY DIFFRACTION (2.02 Å) | 主引用文献 | Systematic Potency and Property Assessment of VHL Ligands and Implications on PROTAC Design. Chemmedchem, 18, 2023
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8B5L
| Cryo-EM structure of ribosome-Sec61-TRAP (TRanslocon Associated Protein) translocon complex | 分子名称: | 28S rRNA, 5.8S rRNA, 5S rRNA, ... | 著者 | Pauwels, E, Shewakramani, N.R, De Wijngaert, B, Vermeire, K, Das, K. | 登録日 | 2022-09-23 | 公開日 | 2023-03-01 | 最終更新日 | 2023-03-15 | 実験手法 | ELECTRON MICROSCOPY (2.86 Å) | 主引用文献 | Structural insights into TRAP association with ribosome-Sec61 complex and translocon inhibition by a CADA derivative. Sci Adv, 9, 2023
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7A5Y
| Crystal structure of tetrameric human H215A-SAMHD1 (residues 109-626) with Rp-dGTP-alphaS (T8T) and Mg | 分子名称: | 2'-deoxyguanosine-5'-O-(1-thiotriphosphate), Deoxynucleoside triphosphate triphosphohydrolase SAMHD1, FE (III) ION, ... | 著者 | Morris, E.R, Kunzelmann, S, Caswell, S.J, Purkiss, A, Taylor, I.A. | 登録日 | 2020-08-24 | 公開日 | 2021-05-26 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (2.29 Å) | 主引用文献 | Probing the Catalytic Mechanism and Inhibition of SAMHD1 Using the Differential Properties of R p - and S p -dNTP alpha S Diastereomers. Biochemistry, 60, 2021
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6OQY
| Human LRH-1 bound to the agonist 6N and a fragment of the Tif2 coregulator | 分子名称: | N-[(1S,3aR,6aR)-5-hexyl-4-phenyl-3a-(1-phenylethenyl)-1,2,3,3a,6,6a-hexahydropentalen-1-yl]sulfuric diamide, Nuclear receptor coactivator 2, Nuclear receptor subfamily 5 group A member 2 | 著者 | Mays, S.G, Ortlund, E.A. | 登録日 | 2019-04-29 | 公開日 | 2019-08-28 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.23 Å) | 主引用文献 | Development of the First Low Nanomolar Liver Receptor Homolog-1 Agonist through Structure-guided Design. J.Med.Chem., 62, 2019
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8JNE
| The cryo-EM structure of the decameric RAD51 ring bound to the nucleosome without the linker DNA binding | 分子名称: | DNA (153-MER), DNA (156-MER), DNA repair protein RAD51 homolog 1, ... | 著者 | Shioi, T, Hatazawa, S, Ogasawara, M, Takizawa, Y, Kurumizaka, H. | 登録日 | 2023-06-06 | 公開日 | 2024-03-27 | 最終更新日 | 2024-05-08 | 実験手法 | ELECTRON MICROSCOPY (4.68 Å) | 主引用文献 | Cryo-EM structures of RAD51 assembled on nucleosomes containing a DSB site. Nature, 628, 2024
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8B6C
| Cryo-EM structure of ribosome-Sec61 in complex with cyclotriazadisulfonamide derivative CK147 | 分子名称: | 28S rRNA, 4-[[9-(cyclohexylmethyl)-3-methylidene-5-(4-methylphenyl)sulfonyl-1,5,9-triazacyclododec-1-yl]sulfonyl]-~{N},~{N}-dimethyl-aniline, 5.8S rRNA, ... | 著者 | Pauwels, E, Shewakramani, N.R, De Wijngaert, B, Vermeire, K, Das, K. | 登録日 | 2022-09-26 | 公開日 | 2023-02-22 | 最終更新日 | 2023-03-15 | 実験手法 | ELECTRON MICROSCOPY (2.79 Å) | 主引用文献 | Structural insights into TRAP association with ribosome-Sec61 complex and translocon inhibition by a CADA derivative. Sci Adv, 9, 2023
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8QZ1
| Crystal structure of human two pore domain potassium ion channel TREK-2 (K2P10.1) in complex with a nanobody (Nb58) | 分子名称: | Isoform B of Potassium channel subfamily K member 10, Nanobody 58, POTASSIUM ION | 著者 | Rodstrom, K.E.J, Pike, A.C.W, Baronina, A, Ang, J, Bushell, S.R, Chalk, R, Mukhopadhyay, S.M.M, Pardon, E, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Burgess-Brown, N.A, Tucker, S.J, Steyaert, J, Carpenter, E.P, Structural Genomics Consortium (SGC) | 登録日 | 2023-10-26 | 公開日 | 2024-05-29 | 実験手法 | X-RAY DIFFRACTION (3.588 Å) | 主引用文献 | Extracellular modulation of TREK-2 activity with nanobodies provides insight into the mechanisms of K2P channel regulation. Nat Commun, 15, 2024
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8JNF
| The cryo-EM structure of the RAD51 filament bound to the nucleosome | 分子名称: | DNA (153-MER), DNA (156-MER), DNA repair protein RAD51 homolog 1, ... | 著者 | Shioi, T, Hatazawa, S, Ogasawara, M, Takizawa, Y, Kurumizaka, H. | 登録日 | 2023-06-06 | 公開日 | 2024-03-27 | 最終更新日 | 2024-05-08 | 実験手法 | ELECTRON MICROSCOPY (6.91 Å) | 主引用文献 | Cryo-EM structures of RAD51 assembled on nucleosomes containing a DSB site. Nature, 628, 2024
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8QZ3
| Crystal structure of human two pore domain potassium ion channel TREK-2 (K2P10.1) in complex with an activatory nanobody (Nb67) | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, Nanobody 67, POTASSIUM ION, ... | 著者 | Baronina, A, Pike, A.C.W, Rodstrom, K.E.J, Ang, J, Bushell, S.R, Chalk, R, Mukhopadhyay, S.M.M, Pardon, E, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Burgess-Brown, N.A, Tucker, S.J, Steyaert, J, Carpenter, E.P, Structural Genomics Consortium (SGC) | 登録日 | 2023-10-26 | 公開日 | 2024-05-29 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Extracellular modulation of TREK-2 activity with nanobodies provides insight into the mechanisms of K2P channel regulation. Nat Commun, 15, 2024
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7R7B
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8QZ4
| Crystal structure of human two pore domain potassium ion channel TREK-2 (K2P10.1) in complex with an activatory nanobody (Nb76) | 分子名称: | BARIUM ION, CHOLESTEROL HEMISUCCINATE, Nanobody 76, ... | 著者 | Rodstrom, K.E.J, Pike, A.C.W, Baronina, A, Ang, J, Bushell, S.R, Chalk, R, Mukhopadhyay, S.M.M, Pardon, E, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Burgess-Brown, N.A, Tucker, S.J, Steyaert, J, Carpenter, E.P, Structural Genomics Consortium (SGC) | 登録日 | 2023-10-26 | 公開日 | 2024-05-29 | 実験手法 | X-RAY DIFFRACTION (3.2 Å) | 主引用文献 | Extracellular modulation of TREK-2 activity with nanobodies provides insight into the mechanisms of K2P channel regulation. Nat Commun, 15, 2024
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8JND
| The cryo-EM structure of the nonameric RAD51 ring bound to the nucleosome with the linker DNA binding | 分子名称: | DNA (153-MER), DNA (156-MER), DNA repair protein RAD51 homolog 1, ... | 著者 | Shioi, T, Hatazawa, S, Ogasawara, M, Takizawa, Y, Kurumizaka, H. | 登録日 | 2023-06-06 | 公開日 | 2024-03-27 | 最終更新日 | 2024-05-08 | 実験手法 | ELECTRON MICROSCOPY (3.66 Å) | 主引用文献 | Cryo-EM structures of RAD51 assembled on nucleosomes containing a DSB site. Nature, 628, 2024
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8BI3
| Structure of E. coli Class 2 L-asparaginase EcAIII, mutant M200W (crystal M200W#1) | 分子名称: | 1,2-ETHANEDIOL, CALCIUM ION, CHLORIDE ION, ... | 著者 | Sciuk, A, Ruszkowski, M, Jaskolski, M, Loch, J.I. | 登録日 | 2022-11-01 | 公開日 | 2023-05-03 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (1.452 Å) | 主引用文献 | The effects of nature-inspired amino acid substitutions on structural and biochemical properties of the E. coli L-asparaginase EcAIII. Protein Sci., 32, 2023
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