8QZ2
Crystal structure of human two pore domain potassium ion channel TREK-2 (K2P10.1) in complex with an inhibitory nanobody (Nb61)
Summary for 8QZ2
Entry DOI | 10.2210/pdb8qz2/pdb |
Descriptor | Potassium channel subfamily K member 10, Nanobody 61, POTASSIUM ION (3 entities in total) |
Functional Keywords | potassium ion channel, nanobody, membrane protein, structural genomics, structural genomics consortium, sgc |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 3 |
Total formula weight | 75474.90 |
Authors | Baronina, A.,Pike, A.C.W.,Rodstrom, K.E.J.,Ang, J.,Bushell, S.R.,Chalk, R.,Mukhopadhyay, S.M.M.,Pardon, E.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Burgess-Brown, N.A.,Tucker, S.J.,Steyaert, J.,Carpenter, E.P.,Structural Genomics Consortium (SGC) (deposition date: 2023-10-26, release date: 2024-05-29) |
Primary citation | Rodstrom, K.E.J.,Cloake, A.,Sormann, J.,Baronina, A.,Smith, K.H.M.,Pike, A.C.W.,Ang, J.,Proks, P.,Schewe, M.,Holland-Kaye, I.,Bushell, S.R.,Elliott, J.,Pardon, E.,Baukrowitz, T.,Owens, R.J.,Newstead, S.,Steyaert, J.,Carpenter, E.P.,Tucker, S.J. Extracellular modulation of TREK-2 activity with nanobodies provides insight into the mechanisms of K2P channel regulation. Nat Commun, 15:4173-4173, 2024 Cited by PubMed: 38755204DOI: 10.1038/s41467-024-48536-2 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.5 Å) |
Structure validation
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