8QZ2
Crystal structure of human two pore domain potassium ion channel TREK-2 (K2P10.1) in complex with an inhibitory nanobody (Nb61)
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005267 | molecular_function | potassium channel activity |
| A | 0016020 | cellular_component | membrane |
| A | 0071805 | biological_process | potassium ion transmembrane transport |
| B | 0005267 | molecular_function | potassium channel activity |
| B | 0016020 | cellular_component | membrane |
| B | 0071805 | biological_process | potassium ion transmembrane transport |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 160 |
| Details | TRANSMEM: Helical => ECO:0000255 |
| Chain | Residue | Details |
| A | VAL77-ALA97 | |
| A | ILE187-ILE207 | |
| A | ILE239-ILE259 | |
| A | LEU304-GLY324 | |
| B | VAL77-ALA97 | |
| B | ILE187-ILE207 | |
| B | ILE239-ILE259 | |
| B | LEU304-GLY324 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 52 |
| Details | INTRAMEM: Pore-forming; Name=Pore-forming 1 => ECO:0007744|PDB:4BW5 |
| Chain | Residue | Details |
| A | LEU159-GLY185 | |
| B | LEU159-GLY185 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 60 |
| Details | TOPO_DOM: Cytoplasmic => ECO:0000255 |
| Chain | Residue | Details |
| A | GLY208-VAL238 | |
| B | GLY208-VAL238 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 62 |
| Details | INTRAMEM: Pore-forming; Name=Pore-forming 2 => ECO:0007744|PDB:4BW5 |
| Chain | Residue | Details |
| A | ALA268-GLU299 | |
| B | ALA268-GLU299 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 16 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:25766236, ECO:0007744|PDB:4XDK |
| Chain | Residue | Details |
| A | THR172 | |
| B | ILE173 | |
| B | GLY174 | |
| B | TYR175 | |
| B | THR281 | |
| B | VAL282 | |
| B | GLY283 | |
| B | PHE284 | |
| A | ILE173 | |
| A | GLY174 | |
| A | TYR175 | |
| A | THR281 | |
| A | VAL282 | |
| A | GLY283 | |
| A | PHE284 | |
| B | THR172 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | SITE: pH sensor => ECO:0000250|UniProtKB:Q8BUW1 |
| Chain | Residue | Details |
| A | HIS156 | |
| B | HIS156 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 6 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255 |
| Chain | Residue | Details |
| A | GLN149 | |
| A | GLN152 | |
| A | GLN153 | |
| B | GLN149 | |
| B | GLN152 | |
| B | GLN153 |
