8QZ2
Crystal structure of human two pore domain potassium ion channel TREK-2 (K2P10.1) in complex with an inhibitory nanobody (Nb61)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Potassium channel subfamily K member 10 | polymer | 274 | 30157.0 | 2 | UniProt (P57789) Pfam (PF07885) | Homo sapiens (human) | |
| 2 | C (C) | Nanobody 61 | polymer | 134 | 15004.4 | 1 | Lama glama | ||
| 3 | D, E, F, G (B) | POTASSIUM ION | non-polymer | 39.1 | 4 | Chemie (K) |
Sequence modifications
A, B: 75 - 340 (UniProt: P57789)
| PDB | External Database | Details |
|---|---|---|
| Met 74 | - | initiating methionine |
| Gln 149 | Asn 144 | engineered mutation |
| Gln 152 | Asn 147 | engineered mutation |
| Gln 153 | Asn 148 | engineered mutation |
| Ala 341 | - | expression tag |
| Glu 342 | - | expression tag |
| Asn 343 | - | expression tag |
| Leu 344 | - | expression tag |
| Tyr 345 | - | expression tag |
| Phe 346 | - | expression tag |
| Gln 347 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 75318.5 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 156.4 | |
| All* | Total formula weight | 75474.9 |
