7A5Y
Crystal structure of tetrameric human H215A-SAMHD1 (residues 109-626) with Rp-dGTP-alphaS (T8T) and Mg
Summary for 7A5Y
Entry DOI | 10.2210/pdb7a5y/pdb |
Descriptor | Deoxynucleoside triphosphate triphosphohydrolase SAMHD1, FE (III) ION, MAGNESIUM ION, ... (5 entities in total) |
Functional Keywords | triphosphohydrolase, metallo-enzyme, binuclear, hd, hydrolase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 8 |
Total formula weight | 494721.91 |
Authors | Morris, E.R.,Kunzelmann, S.,Caswell, S.J.,Purkiss, A.,Taylor, I.A. (deposition date: 2020-08-24, release date: 2021-05-26, Last modification date: 2024-01-31) |
Primary citation | Morris, E.R.,Kunzelmann, S.,Caswell, S.J.,Purkiss, A.G.,Kelly, G.,Taylor, I.A. Probing the Catalytic Mechanism and Inhibition of SAMHD1 Using the Differential Properties of R p - and S p -dNTP alpha S Diastereomers. Biochemistry, 60:1682-1698, 2021 Cited by PubMed: 33988981DOI: 10.1021/acs.biochem.0c00944 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.29 Å) |
Structure validation
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