7A5Y
Crystal structure of tetrameric human H215A-SAMHD1 (residues 109-626) with Rp-dGTP-alphaS (T8T) and Mg
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 8 |
| Details | ACT_SITE: ACT_SITE => ECO:0000305|PubMed:22056990 |
| Chain | Residue | Details |
| A | HIS233 | |
| B | HIS233 | |
| C | HIS233 | |
| D | HIS233 | |
| E | HIS233 | |
| F | HIS233 | |
| G | HIS233 | |
| H | HIS233 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 48 |
| Details | BINDING: in other chain => ECO:0000269|PubMed:24141705, ECO:0000269|PubMed:24217394, ECO:0000269|PubMed:25267621, ECO:0000269|PubMed:25288794, ECO:0000269|PubMed:25760601, ECO:0000269|PubMed:26294762, ECO:0000269|PubMed:26431200 |
| Chain | Residue | Details |
| B | ARG333 | |
| B | ARG352 | |
| B | ASN358 | |
| B | LYS523 | |
| C | LYS116 | |
| C | ASP137 | |
| C | ARG333 | |
| C | ARG352 | |
| C | ASN358 | |
| C | LYS523 | |
| D | LYS116 | |
| D | ASP137 | |
| D | ARG333 | |
| D | ARG352 | |
| D | ASN358 | |
| D | LYS523 | |
| E | LYS116 | |
| E | ASP137 | |
| E | ARG333 | |
| E | ARG352 | |
| E | ASN358 | |
| E | LYS523 | |
| F | LYS116 | |
| F | ASP137 | |
| F | ARG333 | |
| F | ARG352 | |
| F | ASN358 | |
| F | LYS523 | |
| G | LYS116 | |
| G | ASP137 | |
| G | ARG333 | |
| G | ARG352 | |
| G | ASN358 | |
| G | LYS523 | |
| H | LYS116 | |
| H | ASP137 | |
| H | ARG333 | |
| H | ARG352 | |
| H | ASN358 | |
| H | LYS523 | |
| A | LYS116 | |
| A | ASP137 | |
| A | ARG333 | |
| A | ARG352 | |
| A | ASN358 | |
| A | LYS523 | |
| B | LYS116 | |
| B | ASP137 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 40 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:24141705, ECO:0000269|PubMed:24217394, ECO:0000269|PubMed:25267621, ECO:0000269|PubMed:25288794, ECO:0000269|PubMed:25760601, ECO:0000269|PubMed:26294762, ECO:0000269|PubMed:26431200 |
| Chain | Residue | Details |
| B | ARG451 | |
| B | LYS455 | |
| C | ASN119 | |
| C | HIS376 | |
| C | LYS377 | |
| C | ARG451 | |
| C | LYS455 | |
| D | ASN119 | |
| D | HIS376 | |
| D | LYS377 | |
| D | ARG451 | |
| D | LYS455 | |
| E | ASN119 | |
| E | HIS376 | |
| E | LYS377 | |
| E | ARG451 | |
| E | LYS455 | |
| F | ASN119 | |
| F | HIS376 | |
| F | LYS377 | |
| F | ARG451 | |
| F | LYS455 | |
| G | ASN119 | |
| G | HIS376 | |
| G | LYS377 | |
| G | ARG451 | |
| G | LYS455 | |
| H | ASN119 | |
| H | HIS376 | |
| H | LYS377 | |
| H | ARG451 | |
| H | LYS455 | |
| A | HIS376 | |
| A | LYS377 | |
| A | ARG451 | |
| A | LYS455 | |
| B | ASN119 | |
| B | HIS376 | |
| B | LYS377 | |
| A | ASN119 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 64 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:24141705 |
| Chain | Residue | Details |
| C | GLN149 | |
| C | ARG164 | |
| C | HIS210 | |
| C | ASP309 | |
| C | TYR315 | |
| C | ASP319 | |
| C | ARG366 | |
| C | HIS370 | |
| D | GLN149 | |
| D | ARG164 | |
| D | HIS210 | |
| D | ASP309 | |
| D | TYR315 | |
| D | ASP319 | |
| D | ARG366 | |
| D | HIS370 | |
| E | GLN149 | |
| E | ARG164 | |
| E | HIS210 | |
| E | ASP309 | |
| E | TYR315 | |
| E | ASP319 | |
| E | ARG366 | |
| E | HIS370 | |
| F | GLN149 | |
| F | ARG164 | |
| F | HIS210 | |
| F | ASP309 | |
| F | TYR315 | |
| F | ASP319 | |
| F | ARG366 | |
| F | HIS370 | |
| G | GLN149 | |
| G | ARG164 | |
| G | HIS210 | |
| G | ASP309 | |
| G | TYR315 | |
| G | ASP319 | |
| G | ARG366 | |
| G | HIS370 | |
| H | GLN149 | |
| H | ARG164 | |
| H | HIS210 | |
| H | ASP309 | |
| H | TYR315 | |
| H | ASP319 | |
| H | ARG366 | |
| H | HIS370 | |
| A | HIS210 | |
| A | ASP309 | |
| A | TYR315 | |
| A | ASP319 | |
| A | ARG366 | |
| A | HIS370 | |
| B | GLN149 | |
| B | ARG164 | |
| B | HIS210 | |
| B | ASP309 | |
| B | TYR315 | |
| B | ASP319 | |
| B | ARG366 | |
| B | HIS370 | |
| A | GLN149 | |
| A | ARG164 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 32 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:24141705, ECO:0000269|PubMed:24217394, ECO:0000269|PubMed:25288794, ECO:0000269|PubMed:25760601, ECO:0000269|PubMed:26431200 |
| Chain | Residue | Details |
| E | HIS167 | |
| E | HIS206 | |
| E | ASP207 | |
| E | ASP311 | |
| F | HIS167 | |
| F | HIS206 | |
| F | ASP207 | |
| F | ASP311 | |
| G | HIS167 | |
| G | HIS206 | |
| G | ASP207 | |
| G | ASP311 | |
| H | HIS167 | |
| H | HIS206 | |
| H | ASP207 | |
| H | ASP311 | |
| A | ASP207 | |
| A | ASP311 | |
| B | HIS167 | |
| B | HIS206 | |
| B | ASP207 | |
| B | ASP311 | |
| C | HIS167 | |
| C | HIS206 | |
| C | ASP207 | |
| C | ASP311 | |
| D | HIS167 | |
| D | HIS206 | |
| D | ASP207 | |
| D | ASP311 | |
| A | HIS167 | |
| A | HIS206 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 8 |
| Details | MOD_RES: Phosphothreonine; by CDK1 => ECO:0000269|PubMed:23601106, ECO:0000269|PubMed:23602554, ECO:0000269|PubMed:26294762, ECO:0000269|PubMed:26431200, ECO:0000269|PubMed:29610582, ECO:0000269|PubMed:29670289, ECO:0007744|PubMed:17081983, ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:18691976, ECO:0007744|PubMed:19369195, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569 |
| Chain | Residue | Details |
| B | THR592 | |
| C | THR592 | |
| D | THR592 | |
| E | THR592 | |
| F | THR592 | |
| G | THR592 | |
| H | THR592 | |
| A | THR592 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 40 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733 |
| Chain | Residue | Details |
| B | LYS492 | |
| B | LYS622 | |
| C | LYS467 | |
| C | LYS469 | |
| C | LYS492 | |
| C | LYS622 | |
| D | LYS467 | |
| D | LYS469 | |
| D | LYS492 | |
| D | LYS622 | |
| E | LYS467 | |
| E | LYS469 | |
| E | LYS492 | |
| E | LYS622 | |
| F | LYS467 | |
| F | LYS469 | |
| F | LYS492 | |
| F | LYS622 | |
| G | LYS467 | |
| G | LYS469 | |
| G | LYS492 | |
| G | LYS622 | |
| H | LYS467 | |
| H | LYS469 | |
| H | LYS492 | |
| H | LYS622 | |
| A | LYS469 | |
| A | LYS492 | |
| A | LYS622 | |
| B | LYS467 | |
| B | LYS469 | |
| A | LYS467 |
