7A5Y
Crystal structure of tetrameric human H215A-SAMHD1 (residues 109-626) with Rp-dGTP-alphaS (T8T) and Mg
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D, E... (A, B, C, D, E...) | Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 | polymer | 520 | 60141.7 | 8 | UniProt (Q9Y3Z3) Pfam (PF01966) | Homo sapiens (Human) | dNTPase,Dendritic cell-derived IFNG-induced protein,DCIP,Monocyte protein 5,MOP-5,SAM domain and HD domain-containing protein 1,hSAMHD1 |
| 2 | BB, GA, I, IB, KA... (G, D, A, H, E...) | FE (III) ION | non-polymer | 55.8 | 8 | Chemie (FE) | |||
| 3 | AA, BA, CB, DB, HA... (C, G, D, A, H...) | MAGNESIUM ION | non-polymer | 24.3 | 24 | Chemie (MG) | |||
| 4 | AB, CA, DA, EA, EB... (F, C, D, G, H...) | 2'-deoxyguanosine-5'-O-(1-thiotriphosphate) | non-polymer | 523.2 | 24 | Chemie (T8T) | |||
| 5 | MB, NB, OB, PB, QB... (A, B, C, D, E...) | water | water | 18.0 | 343 | Chemie (HOH) |
Sequence modifications
A, B, C, D, E, F, G, H: 109 - 626 (UniProt: Q9Y3Z3)
| PDB | External Database | Details |
|---|---|---|
| Gly 107 | - | expression tag |
| Ser 108 | - | expression tag |
| Ala 215 | His 215 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 8 |
| Total formula weight | 481133.9 | |
| Non-Polymers* | Number of molecules | 56 |
| Total formula weight | 13588.0 | |
| All* | Total formula weight | 494721.9 |
