8BDX

Ternary complex between VCB, BRD4-BD2 and PROTAC 48

Summary for 8BDX

• Entry DOI: 10.2210/pdb8bdx/pdb
• Descriptor: Bromodomain-containing protein 4, Elongin-B, Elongin-C, ... (6 entities in total)
• Functional Keywords: protac, degrader, complex, e3 ligase, vhl, vcb, ligase
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 8
• Total formula weight: 114722.97

Authors

Sorrell, F.J.,Mueller, J.E.,Lehmann, M.,Wegener, A. (deposition date: 2022-10-20, release date: 2023-02-15, Last modification date: 2024-02-07)

• Primary citation: Krieger, J.,Sorrell, F.J.,Wegener, A.A.,Leuthner, B.,Machrouhi-Porcher, F.,Hecht, M.,Leibrock, E.M.,Muller, J.E.,Eisert, J.,Hartung, I.V.,Schlesiger, S.; Systematic Potency and Property Assessment of VHL Ligands and Implications on PROTAC Design.; Chemmedchem, 18:e202200615-e202200615, 2023; PubMed: 36749883; DOI: 10.1002/cmdc.202200615

Experimental method

X-RAY DIFFRACTION (2.93 Å)