6OI2
Crystal structure of human WDR5 in complex with symmetric dimethyl-L-arginine
Summary for 6OI2
Entry DOI | 10.2210/pdb6oi2/pdb |
Descriptor | WD repeat-containing protein 5, SULFATE ION, GLYCEROL, ... (5 entities in total) |
Functional Keywords | methylation, epigenetics, post-translational modification, chromatin, methylarginine, gene regulation |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 35157.72 |
Authors | Lorton, B.M.,Harijan, R.K.,Burgos, E.,Bonanno, J.B.,Almo, S.C.,Shechter, D. (deposition date: 2019-04-08, release date: 2020-04-01, Last modification date: 2023-10-11) |
Primary citation | Lorton, B.M.,Harijan, R.K.,Burgos, E.S.,Bonanno, J.B.,Almo, S.C.,Shechter, D. A Binary Arginine Methylation Switch on Histone H3 Arginine 2 Regulates Its Interaction with WDR5. Biochemistry, 59:3696-3708, 2020 Cited by PubMed: 32207970DOI: 10.1021/acs.biochem.0c00035 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.68 Å) |
Structure validation
Download full validation report