4R5G
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![BU of 4r5g by Molmil](/molmil-images/mine/4r5g) | Crystal structure of the DnaK C-terminus with the inhibitor PET-16 | 分子名称: | Chaperone protein DnaK, triphenyl(phenylethynyl)phosphonium | 著者 | Leu, J.I, Zhang, P, Murphy, M.E, Marmorstein, R, George, D.L. | 登録日 | 2014-08-21 | 公開日 | 2014-09-10 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (3.4501 Å) | 主引用文献 | Structural Basis for the Inhibition of HSP70 and DnaK Chaperones by Small-Molecule Targeting of a C-Terminal Allosteric Pocket. Acs Chem.Biol., 9, 2014
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4MFQ
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![BU of 4mfq by Molmil](/molmil-images/mine/4mfq) | The crystal structure of acyltransferase in complex with CoA and 10C-Teicoplanin | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-amino-2-deoxy-beta-D-glucopyranose, COENZYME A, ... | 著者 | Lyu, S.Y, Liu, Y.C, Chang, C.Y, Huang, C.J, Li, T.L. | 登録日 | 2013-08-28 | 公開日 | 2014-09-03 | 最終更新日 | 2023-12-06 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Multiple complexes of long aliphatic N-acyltransferases lead to synthesis of 2,6-diacylated/2-acyl-substituted glycopeptide antibiotics, effectively killing vancomycin-resistant enterococcus J.Am.Chem.Soc., 136, 2014
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4RGO
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![BU of 4rgo by Molmil](/molmil-images/mine/4rgo) | Structure of Staphylococcal Enterotoxin B bound to the neutralizing antibody 14G8 | 分子名称: | 14G8 heavy chain, 14G8 light chain, ACETATE ION, ... | 著者 | Franklin, M.C, Dutta, K, Varshney, A.K, Goger, M.J, Fries, B.C. | 登録日 | 2014-09-30 | 公開日 | 2015-01-21 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Mechanisms mediating enhanced neutralization efficacy of staphylococcal enterotoxin B by combinations of monoclonal antibodies. J.Biol.Chem., 290, 2015
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4RGW
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![BU of 4rgw by Molmil](/molmil-images/mine/4rgw) | Crystal Structure of a TAF1-TAF7 Complex in Human Transcription Factor IID | 分子名称: | GLYCEROL, Transcription initiation factor TFIID subunit 1, Transcription initiation factor TFIID subunit 7 | 著者 | Wang, H, Curran, E.C, Hinds, T.R, Wang, E.H, Zheng, N. | 登録日 | 2014-09-30 | 公開日 | 2014-12-03 | 最終更新日 | 2014-12-17 | 実験手法 | X-RAY DIFFRACTION (2.301 Å) | 主引用文献 | Crystal structure of a TAF1-TAF7 complex in human transcription factor IID reveals a promoter binding module. Cell Res., 24, 2014
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4R1E
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![BU of 4r1e by Molmil](/molmil-images/mine/4r1e) | Crystal Structure of MTIP from Plasmodium falciparum in complex with a peptide-fragment chimera | 分子名称: | 5-{[(2-aminoethyl)sulfanyl]methyl}furan-2-carbaldehyde, Myosin A tail domain interacting protein, Myosin-A | 著者 | Douse, C.H, Vrielink, N, Cota, E, Tate, E.W. | 登録日 | 2014-08-05 | 公開日 | 2014-11-12 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (1.98 Å) | 主引用文献 | Targeting a Dynamic Protein-Protein Interaction: Fragment Screening against the Malaria Myosin A Motor Complex. Chemmedchem, 10, 2015
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3BB4
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![BU of 3bb4 by Molmil](/molmil-images/mine/3bb4) | Crystal structure of Toc33 from Arabidopsis thaliana in complex with Mg2+ and GMPPNP | 分子名称: | MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, T7I23.11 protein | 著者 | Koenig, P, Sinning, I, Schleiff, E, Tews, I. | 登録日 | 2007-11-09 | 公開日 | 2008-04-01 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (2.85 Å) | 主引用文献 | The GTPase cycle of the chloroplast import receptors Toc33/Toc34: implications from monomeric and dimeric structures. Structure, 16, 2008
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4RGM
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![BU of 4rgm by Molmil](/molmil-images/mine/4rgm) | Structure of Staphylococcal Enterotoxin B bound to the neutralizing antibody 20B1 | 分子名称: | 20B1 heavy chain, 20B1 light chain, Enterotoxin type B | 著者 | Franklin, M.C, Dutta, K, Varshney, A.K, Goger, M.J, Fries, B.C. | 登録日 | 2014-09-30 | 公開日 | 2015-01-21 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2.689 Å) | 主引用文献 | Mechanisms mediating enhanced neutralization efficacy of staphylococcal enterotoxin B by combinations of monoclonal antibodies. J.Biol.Chem., 290, 2015
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4RGN
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![BU of 4rgn by Molmil](/molmil-images/mine/4rgn) | Structure of Staphylococcal Enterotoxin B bound to two neutralizing antibodies, 14G8 and 6D3 | 分子名称: | 14G8 heavy chain, 14G8 light chain, 6D3 heavy chain, ... | 著者 | Franklin, M.C, Dutta, K, Varshney, A.K, Goger, M.J, Fries, B.C. | 登録日 | 2014-09-30 | 公開日 | 2015-01-21 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2.698 Å) | 主引用文献 | Mechanisms mediating enhanced neutralization efficacy of staphylococcal enterotoxin B by combinations of monoclonal antibodies. J.Biol.Chem., 290, 2015
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6TZ3
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![BU of 6tz3 by Molmil](/molmil-images/mine/6tz3) | Crystal Structure of Human Synaptotagmin 1 C2B without Ca2+ | 分子名称: | SULFATE ION, Synaptotagmin-1 | 著者 | Dominguez, M.J, Karmakar, S, Meyer, A.G, Sutton, R.B. | 登録日 | 2019-08-09 | 公開日 | 2020-05-13 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (1.17 Å) | 主引用文献 | Molecular Basis for Synaptotagmin-1-Associated Neurodevelopmental Disorder. Neuron, 107, 2020
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4R5I
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![BU of 4r5i by Molmil](/molmil-images/mine/4r5i) | Crystal structure of the DnaK C-terminus with the substrate peptide NRLLLTG | 分子名称: | Chaperone protein DnaK, HSP70/DnaK Substrate Peptide: NRLLLTG, PHOSPHATE ION, ... | 著者 | Leu, J.I, Zhang, P, Murphy, M.E, Marmorstein, R, George, D.L. | 登録日 | 2014-08-21 | 公開日 | 2014-09-10 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (1.9702 Å) | 主引用文献 | Structural Basis for the Inhibition of HSP70 and DnaK Chaperones by Small-Molecule Targeting of a C-Terminal Allosteric Pocket. Acs Chem.Biol., 9, 2014
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6U41
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![BU of 6u41 by Molmil](/molmil-images/mine/6u41) | 1.7 angstrom structure of a pathogenic human Syt 1 C2B (D304G) | 分子名称: | SULFATE ION, Synaptotagmin-1 | 著者 | Dominguez, M.J, Bradberry, M.M, Chapman, E.R, Sutton, R.B. | 登録日 | 2019-08-22 | 公開日 | 2020-05-13 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Molecular Basis for Synaptotagmin-1-Associated Neurodevelopmental Disorder. Neuron, 107, 2020
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4J5I
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4JFQ
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![BU of 4jfq by Molmil](/molmil-images/mine/4jfq) | A2 HLA complex with L8A heteroclitic variant of Melanoma peptide | 分子名称: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, Beta-2-microglobulin, GLYCEROL, ... | 著者 | Rizkallah, P.J, Cole, D.K, Madura, F, Sewell, A.K, Baker, B.M. | 登録日 | 2013-02-28 | 公開日 | 2013-05-29 | 最終更新日 | 2013-07-17 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | T-cell receptor specificity maintained by altered thermodynamics. J.Biol.Chem., 288, 2013
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6U4U
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![BU of 6u4u by Molmil](/molmil-images/mine/6u4u) | 1.3 A structure of a pathogenic human Syt 1 C2B (I368T) | 分子名称: | SULFATE ION, Synaptotagmin-1 | 著者 | Dominguez, M.J, Bradberry, M.M, Chapman, E.R, Sutton, R.B. | 登録日 | 2019-08-26 | 公開日 | 2020-05-13 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (1.3 Å) | 主引用文献 | Molecular Basis for Synaptotagmin-1-Associated Neurodevelopmental Disorder. Neuron, 107, 2020
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4HBY
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![BU of 4hby by Molmil](/molmil-images/mine/4hby) | Crystal Structure of the first bromodomain of human BRD4 in complex with a quinazolin ligand | 分子名称: | 1,2-ETHANEDIOL, 3-methyl-2-oxo-N-phenyl-1,2,3,4-tetrahydroquinazoline-6-sulfonamide, Bromodomain-containing protein 4 | 著者 | Filippakopoulos, P, Picaud, S, Qi, J, Felletar, I, von Delft, F, Bountra, C, Arrowsmith, C.H, Edwards, A, Fish, P.V, Bunnage, M.E, Cook, A.S, Owen, D.R, Knapp, S, Structural Genomics Consortium (SGC) | 登録日 | 2012-09-28 | 公開日 | 2012-10-31 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (1.59 Å) | 主引用文献 | Identification of a Chemical Probe for Bromo and Extra C-Terminal Bromodomain Inhibition through Optimization of a Fragment-Derived Hit. J.Med.Chem., 55, 2012
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4OIC
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![BU of 4oic by Molmil](/molmil-images/mine/4oic) | Crystal structrual of a soluble protein | 分子名称: | (2Z,4E)-5-[(1S)-1-hydroxy-2,6,6-trimethyl-4-oxocyclohex-2-en-1-yl]-3-methylpenta-2,4-dienoic acid, Bet v I allergen-like, CHLORIDE ION, ... | 著者 | He, Y, Hao, Q, Li, W, Yan, C, Yan, N, Yin, P. | 登録日 | 2014-01-19 | 公開日 | 2015-01-21 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (1.999 Å) | 主引用文献 | Identification and characterization of ABA receptors in Oryza sativa Plos One, 9, 2014
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6IIK
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![BU of 6iik by Molmil](/molmil-images/mine/6iik) | USP14 catalytic domain with IU1 | 分子名称: | 1-[1-(4-fluorophenyl)-2,5-dimethyl-1H-pyrrol-3-yl]-2-(pyrrolidin-1-yl)ethan-1-one, Ubiquitin carboxyl-terminal hydrolase 14 | 著者 | Mei, Z.Q, Wang, Y.W, He, W, Wang, F. | 登録日 | 2018-10-06 | 公開日 | 2018-12-12 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (1.97 Å) | 主引用文献 | Small molecule inhibitors reveal allosteric regulation of USP14 via steric blockade. Cell Res., 28, 2018
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4HBV
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![BU of 4hbv by Molmil](/molmil-images/mine/4hbv) | Crystal Structure of the first bromodomain of human BRD4 in complex with a quinazolin ligand | 分子名称: | 1,2-ETHANEDIOL, 6-bromo-3-methyl-3,4-dihydroquinazolin-2(1H)-one, Bromodomain-containing protein 4 | 著者 | Filippakopoulos, P, Picaud, S, Qi, J, Felletar, I, von Delft, F, Bountra, C, Arrowsmith, C.H, Edwards, A, Fish, P.V, Bunnage, M.E, Cook, A.S, Owen, D.R, Knapp, S, Structural Genomics Consortium (SGC) | 登録日 | 2012-09-28 | 公開日 | 2012-10-31 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (1.63 Å) | 主引用文献 | Identification of a Chemical Probe for Bromo and Extra C-Terminal Bromodomain Inhibition through Optimization of a Fragment-Derived Hit. J.Med.Chem., 55, 2012
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6U77
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![BU of 6u77 by Molmil](/molmil-images/mine/6u77) | yGsy2p in complex with small molecule | 分子名称: | 2-methoxy-4-(1-{2-[(2S)-1-methylpyrrolidin-2-yl]ethyl}-4-phenyl-1H-imidazol-5-yl)phenol, 6-O-phosphono-alpha-D-glucopyranose, Glycogen [starch] synthase isoform 2 | 著者 | Tang, B, Hurley, T.D. | 登録日 | 2019-08-31 | 公開日 | 2020-03-18 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.85 Å) | 主引用文献 | Discovery and Development of Small-Molecule Inhibitors of Glycogen Synthase. J.Med.Chem., 63, 2020
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6T5J
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![BU of 6t5j by Molmil](/molmil-images/mine/6t5j) | Structure of NUDT15 in complex with inhibitor TH1760 | 分子名称: | 6-[4-(1~{H}-indol-5-ylcarbonyl)piperazin-1-yl]sulfonyl-3~{H}-1,3-benzoxazol-2-one, CHLORIDE ION, MAGNESIUM ION, ... | 著者 | Carter, M, Rehling, D, Desroses, M, Zhang, S.M, Hagenkort, A, Valerie, N.C.K, Helleday, T, Stenmark, P. | 登録日 | 2019-10-16 | 公開日 | 2020-07-29 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | Development of a chemical probe against NUDT15. Nat.Chem.Biol., 16, 2020
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6I0M
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![BU of 6i0m by Molmil](/molmil-images/mine/6i0m) | Structure of human IMP dehydrogenase, isoform 2, bound to GDP | 分子名称: | GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-MONOPHOSPHATE, Inosine-5'-monophosphate dehydrogenase 2, ... | 著者 | Buey, R.M, Fernandez-Justel, D, Revuelta, J.L. | 登録日 | 2018-10-26 | 公開日 | 2019-01-30 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (2.567 Å) | 主引用文献 | A Nucleotide-Dependent Conformational Switch Controls the Polymerization of Human IMP Dehydrogenases to Modulate their Catalytic Activity. J. Mol. Biol., 431, 2019
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3B2G
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![BU of 3b2g by Molmil](/molmil-images/mine/3b2g) | Leptolyngbya boryana Ferredoxin | 分子名称: | FE2/S2 (INORGANIC) CLUSTER, Ferredoxin-1 | 著者 | Kurisu, G, Hase, T. | 登録日 | 2011-08-01 | 公開日 | 2012-06-13 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (1.76 Å) | 主引用文献 | A new structural insight into differential interaction of cyanobacterial and plant ferredoxins with nitrite reductase as revealed by NMR and X-ray crystallographic studies J.Biochem., 151, 2012
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4MUB
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![BU of 4mub by Molmil](/molmil-images/mine/4mub) | Schistosoma mansoni (Blood Fluke) Sulfotransferase/Oxamniquine Complex | 分子名称: | ADENOSINE-3'-5'-DIPHOSPHATE, Sulfotransferase, {(2S)-7-nitro-2-[(propan-2-ylamino)methyl]-1,2,3,4-tetrahydroquinolin-6-yl}methanol | 著者 | Valentim, C.L.L, Cioli, D, Chevalier, F.D, Cao, X, Taylor, A.B, Holloway, S.P, Pica-Mattoccia, L, Guidi, A, Basso, A, Tsai, I.J, Berriman, M, Carvalho-Queiroz, C, Almeida, M, Aguilar, H, Frantz, D.E, Hart, P.J, Anderson, T.J.C, LoVerde, P.T. | 登録日 | 2013-09-21 | 公開日 | 2013-12-18 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | 主引用文献 | Genetic and molecular basis of drug resistance and species-specific drug action in schistosome parasites. Science, 342, 2013
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4J5N
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![BU of 4j5n by Molmil](/molmil-images/mine/4j5n) | Crystal Structure of a Deinococcus radiodurans PTE-like lactonase (drPLL) mutant Y28L/D71N/E101G/E179D/V235L/L270M | 分子名称: | COBALT (II) ION, Phosphotriesterase, putative | 著者 | Meier, M.M, Rajendran, C, Malisi, C, Fox, N.G, Xu, C, Schlee, S, Barondeau, D.P, Hocker, B, Sterner, R, Raushel, F.M. | 登録日 | 2013-02-08 | 公開日 | 2013-07-24 | 最終更新日 | 2023-12-06 | 実験手法 | X-RAY DIFFRACTION (2.05 Å) | 主引用文献 | Molecular engineering of organophosphate hydrolysis activity from a weak promiscuous lactonase template. J.Am.Chem.Soc., 135, 2013
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6I9Q
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![BU of 6i9q by Molmil](/molmil-images/mine/6i9q) | Structure of the mouse CD98 heavy chain ectodomain | 分子名称: | 1,2-ETHANEDIOL, 4F2 cell-surface antigen heavy chain, CHLORIDE ION | 著者 | Schiefner, A, Deuschle, F.-C, Skerra, A. | 登録日 | 2018-11-24 | 公開日 | 2019-04-17 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Structural differences between the ectodomains of murine and human CD98hc. Proteins, 87, 2019
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