4HBY

Crystal Structure of the first bromodomain of human BRD4 in complex with a quinazolin ligand

Summary for 4HBY

• Entry DOI: 10.2210/pdb4hby/pdb
• Related: 4HBV 4HBW 4HBX
• Descriptor: Bromodomain-containing protein 4, 3-methyl-2-oxo-N-phenyl-1,2,3,4-tetrahydroquinazoline-6-sulfonamide, 1,2-ETHANEDIOL, ... (4 entities in total)
• Functional Keywords: bromodomain, cap, hunk1, mcap, mitotic chromosome associated protein, cell cycle, structural genomics consortium, sgc, signaling protein-inhibitor complex, signaling protein/inhibitor
• Biological source: Homo sapiens (human)
• Cellular location: Nucleus (By similarity): O60885
• Total number of polymer chains: 1
• Total formula weight: 15478.81

Authors

Filippakopoulos, P.,Picaud, S.,Qi, J.,Felletar, I.,von Delft, F.,Bountra, C.,Arrowsmith, C.H.,Edwards, A.,Fish, P.V.,Bunnage, M.E.,Cook, A.S.,Owen, D.R.,Knapp, S.,Structural Genomics Consortium (SGC) (deposition date: 2012-09-28, release date: 2012-10-31, Last modification date: 2023-09-20)

• Primary citation: Fish, P.V.,Filippakopoulos, P.,Bish, G.,Brennan, P.E.,Bunnage, M.E.,Cook, A.S.,Federov, O.,Gerstenberger, B.S.,Jones, H.,Knapp, S.,Marsden, B.,Nocka, K.,Owen, D.R.,Philpott, M.,Picaud, S.,Primiano, M.J.,Ralph, M.J.,Sciammetta, N.,Trzupek, J.D.; Identification of a Chemical Probe for Bromo and Extra C-Terminal Bromodomain Inhibition through Optimization of a Fragment-Derived Hit.; J.Med.Chem., 55:9831-9837, 2012; PubMed: 23095041; DOI: 10.1021/jm3010515

Experimental method

X-RAY DIFFRACTION (1.59 Å)