PDB: 183283 件ウェブページステータス検索Chemie searchBIRD

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4QLV	yCP in complex with tripeptidic epoxyketone inhibitor 17 分子名称: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, MAGNESIUM ION, N-(morpholin-4-ylacetyl)-D-alanyl-N-[(2S,4R)-5-hydroxy-4-methyl-3-oxo-1-phenylpentan-2-yl]-O-methyl-L-tyrosinamide, ... 著者 de Bruin, G, Huber, E, Xin, B, van Rooden, E, Al-Ayed, K, Kim, K, Kisselev, A, Driessen, C, van der Marel, G, Groll, M, Overkleeft, H. 登録日 2014-06-13 公開日 2014-07-23 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (2.9 Å) 主引用文献 Structure-based design of beta 1i or beta 5i specific inhibitors of human immunoproteasomes J.Med.Chem., 57, 2014
8AYZ	Poliovirus type 2 (strain MEF-1) virus-like particle in complex with capsid binder compound 17 分子名称: 4-[[4-[1,3-bis(oxidanylidene)isoindol-2-yl]phenyl]sulfonylamino]benzoic acid, Capsid protein, VP0, ... 著者 Bahar, M.W, Fry, E.E, Stuart, D.I. 登録日 2022-09-04 公開日 2022-12-07 実験手法 ELECTRON MICROSCOPY (1.88 Å) 主引用文献 A conserved glutathione binding site in poliovirus is a target for antivirals and vaccine stabilisation. Commun Biol, 5, 2022
6N29	Crystal structure of monomeric von Willebrand Factor D`D3 assembly 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, DI(HYDROXYETHYL)ETHER, ... 著者 Dong, X, Arndt, J.W, Springer, T.A. 登録日 2018-11-12 公開日 2019-01-23 最終更新日 2020-07-29 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 The von Willebrand factor D'D3 assembly and structural principles for factor VIII binding and concatemer biogenesis. Blood, 133, 2019
7EUM	Crystal structure of apo Nmar_1308 protein at cryogenic temperature 分子名称: Enoyl-CoA hydratase/isomerase 著者 DeMirci, H, Destan, E, Yuksel, B, Ayan, E. 登録日 2021-05-18 公開日 2021-09-29 最終更新日 2024-05-29 実験手法 X-RAY DIFFRACTION (2.15 Å) 主引用文献 Crystal structure of apo Nmar_1308 protein at cryogenic temperature To Be Published
5TXM	STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE (RT) TERNARY COMPLEX WITH A DOUBLE STRANDED DNA AND AN INCOMING DDATP 分子名称: 1,2-ETHANEDIOL, 2',3'-dideoxyadenosine triphosphate, DNA (5'-D(*CP*AP*GP*TP*CP*CP*CP*TP*GP*TP*TP*CP*GP*GP*(MRG)P*CP*GP*CP*CP*G)-3'), ... 著者 Das, K, Martinez, S.M, Arnold, E. 登録日 2016-11-17 公開日 2017-04-05 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Structural Insights into HIV Reverse Transcriptase Mutations Q151M and Q151M Complex That Confer Multinucleoside Drug Resistance. Antimicrob. Agents Chemother., 61, 2017
8B1U	RecBCD-DNA in complex with the phage protein Abc2 and host PpiB 分子名称: Anti-RecBCD protein 2, DNA (70-MER), MAGNESIUM ION, ... 著者 Wilkinson, M, Wilkinson, O.J, Feyerherm, C, Fletcher, E.E, Wigley, D.B, Dillingham, M.S. 登録日 2022-09-12 公開日 2022-12-28 実験手法 ELECTRON MICROSCOPY (3.8 Å) 主引用文献 Structures of RecBCD in complex with phage-encoded inhibitor proteins reveal distinctive strategies for evasion of a bacterial immunity hub. Elife, 11, 2022
1FFP	CRYSTAL STRUCTURE OF MURINE CLASS I H-2DB COMPLEXED WITH PEPTIDE GP33 (C9M/K1S) 分子名称: BETA-2 MICROGLOBULIN BETA CHAIN, H-2 CLASS I HISTOCOMPATIBILITY ANTIGEN, D-B, ... 著者 Wang, B, Sharma, A, Maile, R, Saad, M, Collins, E.J, Frelinger, J.A. 登録日 2000-07-25 公開日 2002-12-11 最終更新日 2011-07-13 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Peptidic termini play a significant role in TCR recognition J.IMMUNOL., 169, 2002
8CYY	CryoEM structure of amplified alpha-synuclein fibril class B mixed type I/II with extended core from DLB case V 分子名称: Alpha-synuclein 著者 Zhou, Y, Sokratian, A, Xu, E, Viverette, E, Dillard, L, Yuan, Y, Li, J.Y, Matarangas, A, Bouvette, J, Borgnia, M, Bartesaghi, A, West, A. 登録日 2022-05-24 公開日 2023-05-31 最終更新日 2024-06-12 実験手法 ELECTRON MICROSCOPY (3.1 Å) 主引用文献 Structural and functional landscape of alpha-synuclein fibril assemblies amplified from cerebrospinal fluid To Be Published
8B1R	RecBCD in complex with the phage protein gp5.9 分子名称: MAGNESIUM ION, Probable RecBCD inhibitor gp5.9, RecBCD enzyme subunit RecB, ... 著者 Wilkinson, M, Wilkinson, O.J, Feyerherm, C, Fletcher, E.E, Wigley, D.B, Dillingham, M.S. 登録日 2022-09-12 公開日 2022-12-28 実験手法 ELECTRON MICROSCOPY (3.2 Å) 主引用文献 Structures of RecBCD in complex with phage-encoded inhibitor proteins reveal distinctive strategies for evasion of a bacterial immunity hub. Elife, 11, 2022
6MI5	NMR solution structure of lanmodulin (LanM) complexed with yttrium(III) ions 分子名称: Lanmodulin, YTTRIUM (III) ION 著者 Cook, E.C, Featherson, E.R, Showalter, S.A, Cotruvo Jr, J.A. 登録日 2018-09-19 公開日 2018-11-07 最終更新日 2024-05-01 実験手法 SOLUTION NMR 主引用文献 Structural Basis for Rare Earth Element Recognition by Methylobacterium extorquens Lanmodulin. Biochemistry, 58, 2019
8B1T	RecBCD-DNA in complex with the phage protein Abc2 分子名称: Anti-RecBCD protein 2, DNA (70-MER), MAGNESIUM ION, ... 著者 Wilkinson, M, Wilkinson, O.J, Feyerherm, C, Fletcher, E.E, Wigley, D.B, Dillingham, M.S. 登録日 2022-09-12 公開日 2022-12-28 実験手法 ELECTRON MICROSCOPY (3.4 Å) 主引用文献 Structures of RecBCD in complex with phage-encoded inhibitor proteins reveal distinctive strategies for evasion of a bacterial immunity hub. Elife, 11, 2022
6FA4	Antibody derived (Abd-7) small molecule binding to KRAS. 分子名称: 6-(2,3-dihydro-1,4-benzodioxin-5-yl)-~{N}-[4-[(dimethylamino)methyl]phenyl]-2-methoxy-pyridin-3-amine, GTPase KRas, MAGNESIUM ION, ... 著者 Quevedo, C.E, Cruz-Migoni, A, Ehebauer, M.T, Carr, S.B, Phillips, S.V.E, Rabbitts, T.H. 登録日 2017-12-15 公開日 2018-08-22 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (2.02 Å) 主引用文献 Small molecule inhibitors of RAS-effector protein interactions derived using an intracellular antibody fragment. Nat Commun, 9, 2018
5JM8	The structure of ATP-bound aerobactin synthetase IucA from a hypervirulent pathotype of Klebsiella pneumoniae 分子名称: ADENOSINE-5'-TRIPHOSPHATE, Aerobactin synthase IucA, MAGNESIUM ION 著者 Bailey, D.C, Drake, E.J, Gulick, A.M. 登録日 2016-04-28 公開日 2016-06-15 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Structural and Functional Characterization of Aerobactin Synthetase IucA from a Hypervirulent Pathotype of Klebsiella pneumoniae. Biochemistry, 55, 2016
6P9J	crystal structure of human anti staphylococcus aureus antibody STAU-229 Fab 分子名称: TRIS(HYDROXYETHYL)AMINOMETHANE, human anti staphylococcus aureus antibody STAU-229 Fab heavy chain, human anti staphylococcus aureus antibody STAU-229 Fab light chain 著者 Dong, J, Crowe, J.E. 登録日 2019-06-10 公開日 2020-06-17 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Human V H 1-69 Gene-Encoded Human Monoclonal Antibodies against Staphylococcus aureus IsdB Use at Least Three Distinct Modes of Binding To Inhibit Bacterial Growth and Pathogenesis. Mbio, 10, 2019
4QLS	yCP in complex with tripeptidic epoxyketone inhibitor 11 分子名称: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, MAGNESIUM ION, N-(morpholin-4-ylacetyl)-D-alanyl-N-[(2S,4R)-1-cyclohexyl-5-hydroxy-4-methyl-3-oxopentan-2-yl]-O-methyl-L-tyrosinamide, ... 著者 De Bruin, G, Huber, E, Xin, B, Van Rooden, E, Al-Ayed, K, Kim, K, Kisselev, A, Driessen, C, Van der Marel, G, Groll, M, Overkleeft, H. 登録日 2014-06-13 公開日 2014-07-23 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Structure-based design of beta 1i or beta 5i specific inhibitors of human immunoproteasomes J.Med.Chem., 57, 2014
7SNV	H. neapolitanus carboxysomal rubisco/CsoSCA-peptide (1-50)complex 分子名称: Carboxysome shell carbonic anhydrase, Ribulose bisphosphate carboxylase large chain, Ribulose bisphosphate carboxylase small chain 著者 Blikstad, C, Dugan, E, Laughlin, T.G, Liu, M, Shoemaker, S, Remis, J, Savage, D.F. 登録日 2021-10-28 公開日 2023-05-03 最終更新日 2023-11-01 実験手法 ELECTRON MICROSCOPY (2.07 Å) 主引用文献 Identification of a carbonic anhydrase-Rubisco complex within the alpha-carboxysome. Proc.Natl.Acad.Sci.USA, 120, 2023
6PDT	cryoEM structure of yeast glucokinase filament 分子名称: ADENOSINE-5'-TRIPHOSPHATE, Glucokinase-1, MAGNESIUM ION, ... 著者 Lynch, E.M, Dosey, A.M, Farrell, D.P, Stoddard, P.R, Kollman, J.M. 登録日 2019-06-19 公開日 2020-03-11 最終更新日 2020-07-29 実験手法 ELECTRON MICROSCOPY (3.8 Å) 主引用文献 Polymerization in the actin ATPase clan regulates hexokinase activity in yeast. Science, 367, 2020
6T2B	Glycoside hydrolase family 109 from Akkermansia muciniphila in complex with GalNAc and NAD+. 分子名称: 2-acetamido-2-deoxy-alpha-D-galactopyranose, Glycosyl hydrolase family 109 protein 2, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, ... 著者 Chaberski, E.K, Fredslund, F, Teze, D, Shuoker, B, Kunstmann, S, Karlsson, E.N, Hachem, M.A, Welner, D.H. 登録日 2019-10-08 公開日 2020-02-26 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (2.13 Å) 主引用文献 The Catalytic Acid-Base in GH109 Resides in a Conserved GGHGG Loop and Allows for Comparable alpha-Retaining and beta-Inverting Activity in an N-Acetylgalactosaminidase from Akkermansia muciniphila Acs Catalysis, 2020
5JPR	Neutron Structure of Compound II of Ascorbate Peroxidase 分子名称: Ascorbate peroxidase, POTASSIUM ION, PROTOPORPHYRIN IX CONTAINING FE, ... 著者 Kwon, H, Blakeley, M.P, Raven, E.L, Moody, P.C.E. 登録日 2016-05-04 公開日 2016-12-21 最終更新日 2024-05-01 実験手法 NEUTRON DIFFRACTION (1.806 Å), X-RAY DIFFRACTION 主引用文献 Direct visualization of a Fe(IV)-OH intermediate in a heme enzyme. Nat Commun, 7, 2016
6PJE	HIV-1 Protease NL4-3 WT in Complex with LR2-43 分子名称: (3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl [(2S,4S,5S)-4-hydroxy-5-({1-[(methoxycarbonyl)amino]cyclopentane-1-carbonyl}amino)-1,6-diphenylhexan-2-yl]carbamate, Protease NL4-3, SULFATE ION 著者 Lockbaum, G.J, Rusere, L.N, Henes, M, Kosovrasti, K, Lee, S.K, Spielvogel, E, Nalivaika, E.A, Swanstrom, R, KurtYilmaz, N, Schiffer, C.A, Ali, A. 登録日 2019-06-28 公開日 2020-07-01 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.922 Å) 主引用文献 Structural Analysis of Potent Hybrid HIV-1 Protease Inhibitors Containing Bis-tetrahydrofuran in a Pseudosymmetric Dipeptide Isostere. J.Med.Chem., 63, 2020
6PJO	HIV-1 Protease NL4-3 WT in Complex with LR2-42 分子名称: Protease NL4-3, SULFATE ION, methyl [(1S)-1-cyclopentyl-2-({(2S,4S,5S)-5-[({[(3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl]oxy}carbonyl)amino]-4-hydroxy-1,6-diphenylhexan-2-yl}amino)-2-oxoethyl]carbamate 著者 Lockbaum, G.J, Rusere, L.N, Henes, M, Kosovrasti, K, Lee, S.K, Spielvogel, E, Nalivaika, E.A, Swanstrom, R, KurtYilmaz, N, Schiffer, C.A, Ali, A. 登録日 2019-06-28 公開日 2020-07-01 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (1.95 Å) 主引用文献 Structural Analysis of Potent Hybrid HIV-1 Protease Inhibitors Containing Bis-tetrahydrofuran in a Pseudosymmetric Dipeptide Isostere. J.Med.Chem., 63, 2020
6P9I	crystal structure of human anti staphylococcus aureus antibody STAU-399 Fab 分子名称: human anti staphylococcus aureus antibody STAU-399 Fab heavy chain, human anti staphylococcus aureus antibody STAU-399 Fab light chain 著者 Dong, J, Crowe, J.E. 登録日 2019-06-10 公開日 2020-06-17 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Human V H 1-69 Gene-Encoded Human Monoclonal Antibodies against Staphylococcus aureus IsdB Use at Least Three Distinct Modes of Binding To Inhibit Bacterial Growth and Pathogenesis. Mbio, 10, 2019
6MN3	Crystal structure of aminoglycoside acetyltransferase AAC(3)-IVa, apoenzyme 分子名称: Aminoglycoside N(3)-acetyltransferase, AAC(3)-IVa, CHLORIDE ION, ... 著者 Stogios, P.J, Evdokimova, E, Wawrzak, Z, Di Leo, R, Savchenko, A, Joachimiak, A, Satchell, K.J, Center for Structural Genomics of Infectious Diseases (CSGID) 登録日 2018-10-01 公開日 2018-10-24 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Structural and molecular rationale for the diversification of resistance mediated by the Antibiotic_NAT family. Commun Biol, 5, 2022
6P3D	The co-crystal structure of BRAF(V600E) with ponatinib 分子名称: 1,2-ETHANEDIOL, 3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzam ide, AMMONIUM ION, ... 著者 Agianian, B, Gavathiotis, E. 登録日 2019-05-23 公開日 2020-09-23 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (2.11 Å) 主引用文献 Inhibitors of BRAF dimers using an allosteric site. Nat Commun, 11, 2020
6MK1	Cryo-EM of self-assembly peptide filament HEAT_R1 分子名称: peptide HEAT_R1 著者 Wang, F, Hughes, S.A, Orlova, A, Conticello, V.P, Egelman, E.H. 登録日 2018-09-24 公開日 2019-06-26 最終更新日 2024-03-13 実験手法 ELECTRON MICROSCOPY (6 Å) 主引用文献 Ambidextrous helical nanotubes from self-assembly of designed helical hairpin motifs. Proc.Natl.Acad.Sci.USA, 116, 2019

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