5TXM

STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE (RT) TERNARY COMPLEX WITH A DOUBLE STRANDED DNA AND AN INCOMING DDATP

Summary for 5TXM

• Entry DOI: 10.2210/pdb5txm/pdb
• Related: 5TXL 5TXN 5TXO 5TXP
• Related PRD ID: PRD_900003
• Descriptor: HIV-1 Reverse Transcriptase P66 subunit, HIV-1 Reverse Transcriptase P51 subunit, DNA (5'-D(*TP*GP*GP*TP*CP*GP*GP*CP*GP*CP*CP*CP*GP*AP*AP*CP*AP*GP*GP*GP*AP*CP*TP*G)-3'), ... (10 entities in total)
• Functional Keywords: rt, dna, crosslink, n site complex, pyrophosphorolysis, p51, p66, transferase, drug resistance, mutation, transferase-dna complex, transferase/dna
• Biological source: Human immunodeficiency virus type 1 group M subtype B (isolate BH10) (HIV-1); More
• Total number of polymer chains: 8
• Total formula weight: 260185.87

Authors

Das, K.,Martinez, S.M.,Arnold, E. (deposition date: 2016-11-17, release date: 2017-04-05, Last modification date: 2023-10-04)

• Primary citation: Das, K.,Martinez, S.E.,Arnold, E.; Structural Insights into HIV Reverse Transcriptase Mutations Q151M and Q151M Complex That Confer Multinucleoside Drug Resistance.; Antimicrob. Agents Chemother., 61:-, 2017; PubMed: 28396546; DOI: 10.1128/AAC.00224-17

Experimental method

X-RAY DIFFRACTION (2.7 Å)