PDB: 17012 件ウェブページステータス検索Chemie searchBIRD

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3OMO	Fragment-Based Design of novel Estrogen Receptor Ligands 分子名称: 2-(trifluoroacetyl)-1,2,3,4-tetrahydroisoquinolin-6-ol, Estrogen receptor beta, Nuclear receptor coactivator 1 著者 Moecklinghoff, S, van Otterlo, W.A, Rose, R, Fuchs, S, Dominguez Seoane, M, Waldmann, H, Ottmann, C, Brunsveld, L. 登録日 2010-08-27 公開日 2011-03-16 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (2.21 Å) 主引用文献 Design and Evaluation of Fragment-Like Estrogen Receptor Tetrahydroisoquinoline Ligands from a Scaffold-Detection Approach. J.Med.Chem., 54, 2011
6I5W	BlMnBP1 binding protein of an ABC transporter from Bifidobacterium animalis subsp. lactis ATCC27673 in complex with mannobiose 分子名称: ACETATE ION, Solute Binding Protein BlMnBP1, Blac_00780 in complex with mannopentaose, ... 著者 Abou Hachem, M, Ejby, M, Guskov, A, Slotboom, D.J. 登録日 2018-11-14 公開日 2019-04-17 最終更新日 2024-05-15 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Two binding proteins of the ABC transporter that confers growth of Bifidobacterium animalis subsp. lactis ATCC27673 on beta-mannan possess distinct manno-oligosaccharide-binding profiles. Mol.Microbiol., 112, 2019
6NAG	X-ray structure of a secreted C11 cysteine protease from Bacteroides thetaiotaomicron "iotapain 分子名称: Clostripain-related protein, PROLINE 著者 Wolan, D.W, Gonzalez-Paez, G.E, Roncase, E.J. 登録日 2018-12-05 公開日 2019-12-11 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.683 Å) 主引用文献 X-ray Structures of Two Bacteroides thetaiotaomicron C11 Proteases in Complex with Peptide-Based Inhibitors. Biochemistry, 58, 2019
6I6W	Circular permutant of ribosomal protein S6, adding 6aa to C terminal of P68-69 分子名称: 30S ribosomal protein S6,30S ribosomal protein S6 著者 Wang, H, Logan, D.T, Oliveberg, M. 登録日 2018-11-15 公開日 2019-11-27 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.49 Å) 主引用文献 Exposing the distinctive modular behavior of beta-strands and alpha-helices in folded proteins. Proc.Natl.Acad.Sci.USA, 117, 2020
6I8M	THE CATALYTIC FRAGMENT OF POLY(ADP-RIBOSE) POLYMERASE COMPLEXED WITH ISOINDOLINONE INHIBITOR 分子名称: (1~{S})-2-(1-cyclohexylpiperidin-4-yl)-1-methyl-3-oxidanylidene-1~{H}-isoindole-4-carboxamide, Poly [ADP-ribose] polymerase 1 著者 Casale, E, Papeo, G, Montagnoli, A. 登録日 2018-11-20 公開日 2019-05-01 最終更新日 2024-05-15 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Discovery of Stereospecific PARP-1 Inhibitor Isoindolinone NMS-P515. Acs Med.Chem.Lett., 10, 2019
6IAL	Porcine E.coli heat-labile enterotoxin B-pentamer in complex with Lacto-N-neohexaose 分子名称: CALCIUM ION, GLYCEROL, Heat-labile enterotoxin B chain, ... 著者 Heim, J.B, Heggelund, J.E, Krengel, U. 登録日 2018-11-27 公開日 2019-02-27 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.45 Å) 主引用文献 Specificity ofEscherichia coliHeat-Labile Enterotoxin Investigated by Single-Site Mutagenesis and Crystallography. Int J Mol Sci, 20, 2019
6O3B	Crystal structure of Frizzled 7 CRD in complex with F6 Fab 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Antibody Fab F6, Heavy chain, ... 著者 Raman, S, Beilschmidt, M, Fransson, J, Julien, J.P. 登録日 2019-02-26 公開日 2019-04-03 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Structure-guided design fine-tunes pharmacokinetics, tolerability, and antitumor profile of multispecific frizzled antibodies. Proc. Natl. Acad. Sci. U.S.A., 116, 2019
3OLS	Crystal structure of estrogen receptor beta ligand binding domain 分子名称: ESTRADIOL, Estrogen receptor beta, Nuclear receptor coactivator 1 著者 Moecklinghoff, S, Rose, R, Carraz, M, Visser, A, Ottmann, C, Brunsveld, L. 登録日 2010-08-26 公開日 2010-11-17 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Synthesis and crystal structure of a phosphorylated estrogen receptor ligand binding domain. Chembiochem, 11, 2010
6O39	Crystal structure of Frizzled 5 CRD in complex with F2.I Fab 分子名称: 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, ACETATE ION, ... 著者 Raman, S, Beilschmidt, M, Fransson, J, Julien, J.P. 登録日 2019-02-26 公開日 2019-04-03 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Structure-guided design fine-tunes pharmacokinetics, tolerability, and antitumor profile of multispecific frizzled antibodies. Proc. Natl. Acad. Sci. U.S.A., 116, 2019
6NYH	Structure of human RIPK1 kinase domain in complex with GNE684 分子名称: (5S)-N-[(3S)-7-methoxy-1-methyl-2-oxo-2,3,4,5-tetrahydro-1H-pyrido[3,4-b]azepin-3-yl]-5-phenyl-6,7-dihydro-5H-pyrrolo[1,2-b][1,2,4]triazole-2-carboxamide, IODIDE ION, Receptor-interacting serine/threonine-protein kinase 1 著者 Fong, R, Lupardus, P.J. 登録日 2019-02-11 公開日 2019-05-29 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 RIP1 inhibition blocks inflammatory diseases but not tumor growth or metastases. Cell Death Differ., 27, 2020
1GTV	CRYSTAL STRUCTURE OF MYCOBACTERIUM TUBERCULOSIS THYMIDYLATE KINASE COMPLEXED WITH THYMIDINE-5'-DIPHOSPHATE (TDP) 分子名称: ACETATE ION, MAGNESIUM ION, SULFATE ION, ... 著者 Ursby, T, Weik, M, Fioravanti, E, Delarue, M, Goeldner, M, Bourgeois, D. 登録日 2002-01-21 公開日 2002-03-28 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (1.55 Å) 主引用文献 Cryophotolysis of Caged Compounds: A Technique for Trapping Intermediate States in Protein Crystals Acta Crystallogr.,Sect.D, 58, 2002
1HFQ	COMPARISON OF TERNARY CRYSTAL COMPLEXES OF HUMAN DIHYDROFOLATE REDUCTASE WITH NADPH AND A CLASSICAL ANTITUMOR FUROPYRIMDINE 分子名称: DIHYDROFOLATE REDUCTASE, N-[4-[(2,4-DIAMINOFURO[2,3D]PYRIMIDIN-5-YL)METHYL]METHYLAMINO]-BENZOYL]-L-GLUTAMATE, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE 著者 Cody, V, Galitsky, N, Luft, J.R, Pangborn, W, Blakley, R.L, Gangjee, A. 登録日 1997-11-04 公開日 1998-01-28 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Comparison of ternary crystal complexes of F31 variants of human dihydrofolate reductase with NADPH and a classical antitumor furopyrimidine. Anti-Cancer Drug Des., 13, 1998
1GOL	COORDINATES OF RAT MAP KINASE ERK2 WITH AN ARGININE MUTATION AT POSITION 52 分子名称: ADENOSINE-5'-TRIPHOSPHATE, EXTRACELLULAR REGULATED KINASE 2, MAGNESIUM ION 著者 Harkins, P.C, Zhang, F, Goldsmith, E.J. 登録日 1996-01-23 公開日 1997-03-12 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Mutation of position 52 in ERK2 creates a nonproductive binding mode for adenosine 5'-triphosphate. Biochemistry, 35, 1996
1HFH	SOLUTION STRUCTURE OF A PAIR OF COMPLEMENT MODULES BY NUCLEAR MAGNETIC RESONANCE 分子名称: FACTOR H, 15TH AND 16TH C-MODULE PAIR 著者 Barlow, P.N, Steinkasserer, A, Norman, D.G, Kieffer, B, Wiles, A.P, Sim, R.B, Campbell, I.D. 登録日 1993-02-23 公開日 1993-07-15 最終更新日 2022-02-23 実験手法 SOLUTION NMR 主引用文献 Solution structure of a pair of complement modules by nuclear magnetic resonance. J.Mol.Biol., 232, 1993
1HFI	SOLUTION STRUCTURE OF A PAIR OF COMPLEMENT MODULES BY NUCLEAR MAGNETIC RESONANCE 分子名称: FACTOR H, 15TH C-MODULE PAIR 著者 Barlow, P.N, Steinkasserer, A, Norman, D.G, Kieffer, B, Wiles, A.P, Sim, R.B, Campbell, I.D. 登録日 1993-02-23 公開日 1993-07-15 最終更新日 2022-02-23 実験手法 SOLUTION NMR 主引用文献 Solution structure of a pair of complement modules by nuclear magnetic resonance. J.Mol.Biol., 232, 1993
8EG3	Structure of human placental steroid (estrone/DHEA) sulfatase at 2.0 angstrom resolution 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, PHOSPHATE ION, ... 著者 Ghosh, D. 登録日 2022-09-10 公開日 2022-12-07 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (2.04 Å) 主引用文献 Structure of human placental steroid sulfatase at 2.0 angstrom resolution: Catalysis, quaternary association, and a secondary ligand site. J.Steroid Biochem.Mol.Biol., 227, 2022
1GUK	CRYSTAL STRUCTURE OF MURINE ALPHA-CLASS GSTA4-4 分子名称: GLUTATHIONE S-TRANSFERASE A4-4 著者 Krengel, U, Schroter, K.H, Hoier, H, Dijkstra, B.W. 登録日 1997-12-11 公開日 1998-04-08 最終更新日 2024-05-22 実験手法 X-RAY DIFFRACTION (2.9 Å) 主引用文献 Crystal structure of a murine alpha-class glutathione S-transferase involved in cellular defense against oxidative stress. FEBS Lett., 422, 1998
7ZVB	Crystal Structure of the mature form of the glutamic-class prolyl-endopeptidase neprosin at 2.35 A resolution. 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, C-terminal peptidase, TRIETHYLENE GLYCOL, ... 著者 Del Amo-Maestro, L, Eckhard, U, Rodriguez-Banqueri, A, Mendes, S.R, Guevara, T, Gomis-Ruth, F.X. 登録日 2022-05-14 公開日 2022-08-10 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (2.35 Å) 主引用文献 Molecular and in vivo studies of a glutamate-class prolyl-endopeptidase for coeliac disease therapy. Nat Commun, 13, 2022
7ZPK	Mammalian Dicer in the "pre-dicing state" with pre-miR-15a substrate and TARBP2 subunit 分子名称: 59-nt precursor of miR-15a, Endoribonuclease Dicer, RISC-loading complex subunit TARBP2 著者 Zanova, M, Zapletal, D, Kubicek, K, Stefl, R, Pinkas, M, Novacek, J. 登録日 2022-04-27 公開日 2022-11-16 実験手法 ELECTRON MICROSCOPY (3.81 Å) 主引用文献 Structural and functional basis of mammalian microRNA biogenesis by Dicer. Mol.Cell, 82, 2022
7ZPI	Mammalian Dicer in the "dicing state" with pre-miR-15a substrate 分子名称: 59-nt precursor of miR-15a, Endoribonuclease Dicer 著者 Zanova, M, Zapletal, D, Kubicek, K, Stefl, R, Pinkas, M, Novacek, J. 登録日 2022-04-27 公開日 2022-11-16 実験手法 ELECTRON MICROSCOPY (5.91 Å) 主引用文献 Structural and functional basis of mammalian microRNA biogenesis by Dicer. Mol.Cell, 82, 2022
6O3A	Crystal structure of Frizzled 7 CRD in complex with F7.B Fab 分子名称: 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, 3-CYCLOHEXYL-1-PROPYLSULFONIC ACID, ... 著者 Raman, S, Beilschmidt, M, Fransson, J, Julien, J.P. 登録日 2019-02-26 公開日 2019-04-03 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Structure-guided design fine-tunes pharmacokinetics, tolerability, and antitumor profile of multispecific frizzled antibodies. Proc. Natl. Acad. Sci. U.S.A., 116, 2019
1H25	CDK2/Cyclin A in complex with an 11-residue recruitment peptide from retinoblastoma-associated protein 分子名称: CELL DIVISION PROTEIN KINASE 2, CYCLIN A2, RETINOBLASTOMA-ASSOCIATED PROTEIN 著者 Tews, I, Cheng, K.Y, Lowe, E.D, Noble, M.E.M, Brown, N.R, Gul, S, Gamblin, S, Johnson, L.N. 登録日 2002-07-31 公開日 2003-02-01 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Specificity Determinants of Recruitment Peptides Bound to Phospho-Cdk2/Cyclin A Biochemistry, 41, 2002
8DYG	IL17A homodimer bound to Compound 7 分子名称: (5P)-2-hydroxy-5-(6-methylquinolin-5-yl)benzoic acid, Interleukin-17A 著者 Argiriadi, M.A, Goedken, E.R. 登録日 2022-08-04 公開日 2022-09-07 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (1.49 Å) 主引用文献 Identification and structure-based drug design of cell-active inhibitors of interleukin 17A at a novel C-terminal site. Sci Rep, 12, 2022
3BO8	The High Resolution Crystal Structure of HLA-A1 Complexed with the MAGE-A1 Peptide 分子名称: Beta-2-microglobulin, GLYCEROL, HLA class I histocompatibility antigen, ... 著者 Kumar, P, Vahedi-Faridi, A, Saenger, W, Ziegler, A, Uchanska-Ziegler, B. 登録日 2007-12-17 公開日 2008-12-23 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Conformational changes within the HLA-A1:MAGE-A1 complex induced by binding of a recombinant antibody fragment with TCR-like specificity Protein Sci., 18, 2009
4RWI	Crystal structure of V561M FGFR1 gatekeeper mutation (C488A, C584S, V561M), apo 分子名称: Fibroblast growth factor receptor 1 著者 Sohl, C.D, Anderson, K.S. 登録日 2014-12-04 公開日 2015-04-15 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.292 Å) 主引用文献 Illuminating the Molecular Mechanisms of Tyrosine Kinase Inhibitor Resistance for the FGFR1 Gatekeeper Mutation: The Achilles' Heel of Targeted Therapy. Acs Chem.Biol., 10, 2015

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