6NYH

Structure of human RIPK1 kinase domain in complex with GNE684

Summary for 6NYH

• Entry DOI: 10.2210/pdb6nyh/pdb
• Descriptor: Receptor-interacting serine/threonine-protein kinase 1, (5S)-N-[(3S)-7-methoxy-1-methyl-2-oxo-2,3,4,5-tetrahydro-1H-pyrido[3,4-b]azepin-3-yl]-5-phenyl-6,7-dihydro-5H-pyrrolo[1,2-b][1,2,4]triazole-2-carboxamide, IODIDE ION, ... (4 entities in total)
• Functional Keywords: rip1, kinase, rip, rip1k ripk1, immune system, transferase-transferase inhibitor complex
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 68852.08

Authors

Fong, R.,Lupardus, P.J. (deposition date: 2019-02-11, release date: 2019-05-29, Last modification date: 2023-10-11)

• Primary citation: Patel, S.,Webster, J.D.,Varfolomeev, E.,Kwon, Y.C.,Cheng, J.H.,Zhang, J.,Dugger, D.L.,Wickliffe, K.E.,Maltzman, A.,Sujatha-Bhaskar, S.,Bir Kohli, P.,Ramaswamy, S.,Deshmukh, G.,Liederer, B.M.,Fong, R.,Hamilton, G.,Lupardus, P.,Caplazi, P.,Lee, W.P.,van Lookeren Campagne, M.,Johnson, A.,McKenzie, B.S.,Junttila, M.R.,Newton, K.,Vucic, D.; RIP1 inhibition blocks inflammatory diseases but not tumor growth or metastases.; Cell Death Differ., 27:161-175, 2020; PubMed: 31101885; DOI: 10.1038/s41418-019-0347-0

Experimental method

X-RAY DIFFRACTION (2.1 Å)