6NYH
Structure of human RIPK1 kinase domain in complex with GNE684
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B | Receptor-interacting serine/threonine-protein kinase 1 | polymer | 296 | 33612.9 | 2 | UniProt (Q13546) Pfam (PF07714) In PDB | Homo sapiens (Human) | Cell death protein RIP,Receptor-interacting protein 1,RIP-1 |
| 2 | A, B | (5S)-N-[(3S)-7-methoxy-1-methyl-2-oxo-2,3,4,5-tetrahydro-1H-pyrido[3,4-b]azepin-3-yl]-5-phenyl-6,7-dihydro-5H-pyrrolo[1,2-b][1,2,4]triazole-2-carboxamide | non-polymer | 432.5 | 2 | Chemie (L8D) | |||
| 3 | A, B | IODIDE ION | non-polymer | 126.9 | 6 | Chemie (IOD) | |||
| 4 | water | water | 18.0 | 201 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 294 (UniProt: Q13546)
| PDB | External Database | Details |
|---|---|---|
| Gly -1 | - | expression tag |
| Ser 0 | - | expression tag |
| Ala 34 | Cys 34 | engineered mutation |
| Ala 127 | Cys 127 | engineered mutation |
| Ala 233 | Cys 233 | engineered mutation |
| Ala 240 | Cys 240 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 67225.7 | |
| Non-Polymers* | Number of molecules | 8 |
| Total formula weight | 1626.4 | |
| All* | Total formula weight | 68852.1 |
