3OMO
Fragment-Based Design of novel Estrogen Receptor Ligands
Summary for 3OMO
Entry DOI | 10.2210/pdb3omo/pdb |
Related | 3OLM 3OLS 3OMP 3OMQ |
Descriptor | Estrogen receptor beta, Nuclear receptor coactivator 1, 2-(trifluoroacetyl)-1,2,3,4-tetrahydroisoquinolin-6-ol, ... (4 entities in total) |
Functional Keywords | steroid binding, protein binding |
Biological source | Homo sapiens (human) More |
Cellular location | Nucleus: Q92731 Nucleus (By similarity): Q15788 |
Total number of polymer chains | 4 |
Total formula weight | 59177.75 |
Authors | Moecklinghoff, S.,van Otterlo, W.A.,Rose, R.,Fuchs, S.,Dominguez Seoane, M.,Waldmann, H.,Ottmann, C.,Brunsveld, L. (deposition date: 2010-08-27, release date: 2011-03-16, Last modification date: 2024-02-21) |
Primary citation | van Otterlo, W.A.,Rose, R.,Fuchs, S.,Zimmermann, T.J.,Dominguez Seoane, M.,Waldmann, H.,Ottmann, C.,Brunsveld, L. Design and Evaluation of Fragment-Like Estrogen Receptor Tetrahydroisoquinoline Ligands from a Scaffold-Detection Approach. J.Med.Chem., 54:2005-2011, 2011 Cited by PubMed: 21381753DOI: 10.1021/jm1011116 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.21 Å) |
Structure validation
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