PDB: 42091 件ウェブページステータス検索Chemie searchBIRD

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9L2G	Structure of SARM1 2C-mutant bound to M1 分子名称: NAD(+) hydrolase SARM1, [(2~{R},3~{S},4~{R},5~{R})-3,4-bis(oxidanyl)-5-(3-sulfanylpyridin-1-yl)oxolan-2-yl]methyl dihydrogen phosphate 著者 Huang, Y, Zhang, J, Zheng, S, Wang, X. 登録日 2024-12-17 公開日 2025-03-19 実験手法 ELECTRON MICROSCOPY (3.27 Å) 主引用文献 Stepwise Activation of SARM1 by a Biosynthetic NMN mimic To Be Published
1CW9	DNA DECAMER WITH AN ENGINEERED CROSSLINK IN THE MINOR GROOVE 分子名称: 5'-D(*CP*CP*AP*GP*(G47)P*CP*CP*TP*GP*G)-3', CALCIUM ION 著者 van Aalten, D.M.F, Erlanson, D.A, Verdine, G.L, Joshua-Tor, L. 登録日 1999-08-26 公開日 1999-10-14 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (1.55 Å) 主引用文献 A structural snapshot of base-pair opening in DNA. Proc.Natl.Acad.Sci.USA, 96, 1999
9L47	Crystal structure of HLA-C*12:03-MY9 分子名称: Beta-2-microglobulin, MHC class I antigen, MY9 著者 Yang, M, Zhong, P.L, Wei, P.C. 登録日 2024-12-20 公開日 2025-03-19 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Biochemical and structural insights into position 97 micropolymorphisms in human leukocyte antigen (HLA)-C*12 allotypes and their differential disease associations. Int.J.Biol.Macromol., 306, 2025
5NQ3	'Porcine (Sus scrofa) Major Histocompatibility Complex, class I, with human beta2 micro globulin, presenting EFEDLTFLA 分子名称: 1,2-ETHANEDIOL, Beta-2-microglobulin, GLU-PHE-GLU-ASP-LEU-THR-PHE-LEU-ALA, ... 著者 Rizkallah, P.J, Tungatt, K, Sewell, A.K. 登録日 2017-04-19 公開日 2018-04-25 最終更新日 2024-10-16 実験手法 X-RAY DIFFRACTION (1.57 Å) 主引用文献 Induction of influenza-specific local CD8 T-cells in the respiratory tract after aerosol delivery of vaccine antigen or virus in the Babraham inbred pig. Plos Pathog., 14, 2018
9N3R	Crystal structure of PRMT5:MEP50 in complex with MTA and TNG462 分子名称: 1,2-ETHANEDIOL, 5'-DEOXY-5'-METHYLTHIOADENOSINE, CHLORIDE ION, ... 著者 Whittington, D.A. 登録日 2025-01-31 公開日 2025-03-12 最終更新日 2025-03-19 実験手法 X-RAY DIFFRACTION (2.47 Å) 主引用文献 Discovery of TNG462: A Highly Potent and Selective MTA-Cooperative PRMT5 Inhibitor to Target Cancers with MTAP Deletion. J.Med.Chem., 68, 2025
9L2E	Structure of SARM1 bound to M1 in the intermediate state 2 分子名称: NAD(+) hydrolase SARM1 著者 Huang, Y, Zhang, J, Zheng, S, Wang, X. 登録日 2024-12-17 公開日 2025-03-12 実験手法 ELECTRON MICROSCOPY (2.46 Å) 主引用文献 Stepwise Activation of SARM1 For Cell Death and Axon Degeneration Revealed by a Biosynthetic NMN Mimic To Be Published
9LKY	Dimer of CRL2-FEM1B bound with PLD6 分子名称: Cullin-2, E3 ubiquitin-protein ligase RBX1, N-terminally processed, ... 著者 Zhao, S, Xu, C. 登録日 2025-01-17 公開日 2025-04-09 最終更新日 2025-05-07 実験手法 ELECTRON MICROSCOPY (3.93 Å) 主引用文献 TOM20-driven E3 ligase recruitment regulates mitochondrial dynamics through PLD6. Nat.Chem.Biol., 2025
1CZA	MUTANT MONOMER OF RECOMBINANT HUMAN HEXOKINASE TYPE I COMPLEXED WITH GLUCOSE, GLUCOSE-6-PHOSPHATE, AND ADP 分子名称: 6-O-phosphono-alpha-D-glucopyranose, ADENOSINE-5'-DIPHOSPHATE, HEXOKINASE TYPE I, ... 著者 Aleshin, A.E, Liu, X, Kirby, C, Bourenkov, G.P, Bartunik, H.D, Fromm, H.J, Honzatko, R.B. 登録日 1999-09-01 公開日 2000-03-06 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Crystal structures of mutant monomeric hexokinase I reveal multiple ADP binding sites and conformational changes relevant to allosteric regulation. J.Mol.Biol., 296, 2000
9N3P	Crystal structure of PRMT5:MEP50 in complex with MTA and oxamide compound 30 分子名称: 1,2-ETHANEDIOL, 5'-DEOXY-5'-METHYLTHIOADENOSINE, CHLORIDE ION, ... 著者 Whittington, D.A. 登録日 2025-01-31 公開日 2025-03-12 最終更新日 2025-03-19 実験手法 X-RAY DIFFRACTION (2.51 Å) 主引用文献 Discovery of TNG462: A Highly Potent and Selective MTA-Cooperative PRMT5 Inhibitor to Target Cancers with MTAP Deletion. J.Med.Chem., 68, 2025
2I8A	Salmonella typhimurium liganded by phosphate ion at 1.64A resolution 分子名称: PHOSPHATE ION, Uridine phosphorylase 著者 Timofeev, V.I, Gabdoulkhakov, A.G, Mikhailov, A.M. 登録日 2006-09-01 公開日 2007-09-04 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (1.64 Å) 主引用文献 Salmonella typhimurium liganded by phosphate ion at 1.64A resolution To be Published
5NQK	human 199.16 TCR in complex with Melan-A/MART-1 (26-35) peptide and HLA-A2 分子名称: Beta-2-microglobulin, HLA class I histocompatibility antigen, A-2 alpha chain, ... 著者 Exertier, C, Reiser, J.-B, Lantez, V, Chouquet, A, Bonneville, M, Saulquin, X, Housset, D. 登録日 2017-04-20 公開日 2018-05-30 最終更新日 2024-11-06 実験手法 X-RAY DIFFRACTION (3.25 Å) 主引用文献 human 199.16 TCR in complex with Melan-A/MART-1 (26-35) peptide and HLA-A2 To Be Published
1D6N	TERNARY COMPLEX STRUCTURE OF HUMAN HGPRTASE, PRPP, MG2+, AND THE INHIBITOR HPP REVEALS THE INVOLVEMENT OF THE FLEXIBLE LOOP IN SUBSTRATE BINDING 分子名称: 1-O-pyrophosphono-5-O-phosphono-alpha-D-ribofuranose, 3H-PYRAZOLO[4,3-D]PYRIMIDIN-7-OL, MAGNESIUM ION, ... 著者 Balendiran, G.K. 登録日 1999-10-14 公開日 1999-12-30 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Ternary complex structure of human HGPRTase, PRPP, Mg2+, and the inhibitor HPP reveals the involvement of the flexible loop in substrate binding. Protein Sci., 8, 1999
1CL0	CRYSTAL STRUCTURE OF REDUCED THIOREDOXIN REDUCTASE FROM ESCHERICHIA COLI. 分子名称: FLAVIN-ADENINE DINUCLEOTIDE, THIOREDOXIN REDUCTASE 著者 Lennon, B.W, Williams Jr, C.H, Ludwig, M.L. 登録日 1999-05-04 公開日 1999-12-03 最終更新日 2023-08-09 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Crystal structure of reduced thioredoxin reductase from Escherichia coli: structural flexibility in the isoalloxazine ring of the flavin adenine dinucleotide cofactor. Protein Sci., 8, 1999
2LR1	Structural Mechanism for Bax Inhibition by Cytomegalovirus Protein vMIA 分子名称: Apoptosis regulator BAX, Immediate early glycoprotein 著者 Ma, J. 登録日 2012-03-20 公開日 2012-12-05 最終更新日 2024-05-01 実験手法 SOLUTION NMR 主引用文献 Structural mechanism of Bax inhibition by cytomegalovirus protein vMIA. Proc.Natl.Acad.Sci.USA, 109, 2012
1CRA	THE COMPLEX BETWEEN HUMAN CARBONIC ANHYDRASE II AND THE AROMATIC INHIBITOR 1,2,4-TRIAZOLE 分子名称: 1,2,4-TRIAZOLE, CARBONIC ANHYDRASE II, MERCURY (II) ION, ... 著者 Mangani, S, Liljas, A. 登録日 1992-10-21 公開日 1994-01-31 最終更新日 2024-10-30 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Crystal structure of the complex between human carbonic anhydrase II and the aromatic inhibitor 1,2,4-triazole. J.Mol.Biol., 232, 1993
1CR6	CRYSTAL STRUCTURE OF MURINE SOLUBLE EPOXIDE HYDROLASE COMPLEXED WITH CPU INHIBITOR 分子名称: EPOXIDE HYDROLASE, N-CYCLOHEXYL-N'-(PROPYL)PHENYL UREA 著者 Argiriadi, M.A, Morisseau, C, Hammock, B.D, Christianson, D.W. 登録日 1999-08-13 公開日 1999-11-19 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Detoxification of environmental mutagens and carcinogens: structure, mechanism, and evolution of liver epoxide hydrolase. Proc.Natl.Acad.Sci.USA, 96, 1999
1CVC	REDESIGNING THE ZINC BINDING SITE OF HUMAN CARBONIC ANHYDRASE II: STRUCTURE OF A HIS2ASP-ZN2+ METAL COORDINATION POLYHEDRON 分子名称: CARBONIC ANHYDRASE II, ZINC ION 著者 Ippolito, J.A, Christianson, D.W. 登録日 1993-09-22 公開日 1994-01-31 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 REDESIGNING THE ZINC-BINDING SITE OF HUMAN CARBONIC ANHYDRASE-II - STRUCTURE OF A HIS2ASP-ZN2+ METAL COORDINATION POLYHEDRON. J.Am.Chem.Soc., 115, 1993
1CNX	SECONDARY INTERACTIONS SIGNIFICANTLY REMOVED FROM THE SULFONAMIDE BINDING POCKET OF CARBONIC ANHYDRASE II INFLUENCE BINDING CONSTANTS 分子名称: AMINODI(ETHYLOXY)ETHYLAMINOCARBONYLBENZENESULFONAMIDE, CARBONIC ANHYDRASE II, MERCURY (II) ION, ... 著者 Boriack, P.A, Christianson, D.W. 登録日 1995-07-21 公開日 1995-11-14 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Secondary interactions significantly removed from the sulfonamide binding pocket of carbonic anhydrase II influence inhibitor binding constants. J.Med.Chem., 38, 1995
8OWO	SMYD3 in complex with fragment FL01507 分子名称: 3-oxidanylbenzenecarbonitrile, GLYCEROL, Histone-lysine N-methyltransferase SMYD3, ... 著者 Lund, B.A, Cederfelt, D, Dobritzsch, D. 登録日 2023-04-28 公開日 2023-08-30 最終更新日 2024-07-03 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Identification of fragments targeting SMYD3 using highly sensitive kinetic and multiplexed biosensor-based screening. Rsc Med Chem, 15, 2024
1CTR	DRUG BINDING BY CALMODULIN: CRYSTAL STRUCTURE OF A CALMODULIN-TRIFLUOPERAZINE COMPLEX 分子名称: 10-[3-(4-METHYL-PIPERAZIN-1-YL)-PROPYL]-2-TRIFLUOROMETHYL-10H-PHENOTHIAZINE, CALCIUM ION, CALMODULIN 著者 Cook, W.J, Walter, L.J, Walter, M.R. 登録日 1994-09-21 公開日 1994-12-20 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (2.45 Å) 主引用文献 Drug binding by calmodulin: crystal structure of a calmodulin-trifluoperazine complex. Biochemistry, 33, 1994
5NWT	Crystal Structure of Escherichia coli RNA polymerase - Sigma54 Holoenzyme complex 分子名称: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... 著者 Zhang, X, Buck, M, Darbari, V.C, Yang, Y, Zhang, N, Lu, D, Glyde, R, Wang, Y, Winkelman, J, Gourse, R.L, Murakami, K.S. 登録日 2017-05-08 公開日 2017-09-13 最終更新日 2024-10-23 実験手法 X-RAY DIFFRACTION (3.76 Å) 主引用文献 TRANSCRIPTION. Structures of the RNA polymerase-Sigma54 reveal new and conserved regulatory strategies. Science, 349, 2015
5HKV	The crystal structure of the large ribosomal subunit of Staphylococcus aureus in complex with lincomycin 分子名称: (4S)-2-METHYL-2,4-PENTANEDIOL, 23s ribosomal RNA, 50S ribosomal protein L13, ... 著者 Yonath, A, Matzov, D, Eyal, Z, Ben Hamou, R, Zimmerman, E, Rozenberg, H, Bashan, A, Fridman, M. 登録日 2016-01-14 公開日 2017-05-03 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (3.66 Å) 主引用文献 Structural insights of lincosamides targeting the ribosome of Staphylococcus aureus. Nucleic Acids Res., 45, 2017
8PBL	E. coli RNA polymerase elongation complex stalled at thymine dimer lesion 分子名称: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... 著者 Woodgate, J, Zenkin, N. 登録日 2023-06-09 公開日 2023-10-25 最終更新日 2024-03-06 実験手法 ELECTRON MICROSCOPY (2.87 Å) 主引用文献 Translation selectively destroys non-functional transcription complexes. Nature, 626, 2024
8PMR	NADase from Aspergillus fumigatus with mutated calcium binding motif (D219A/E220A) 分子名称: 1,2-ETHANEDIOL, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... 著者 Kallio, J.P, Ferrario, E, Stromland, O, Ziegler, M. 登録日 2023-06-29 公開日 2023-11-15 最終更新日 2024-11-06 実験手法 X-RAY DIFFRACTION (1.94 Å) 主引用文献 Novel Calcium-Binding Motif Stabilizes and Increases the Activity of Aspergillus fumigatus Ecto-NADase. Biochemistry, 62, 2023
8PMS	NADase from Aspergillus fumigatus with replaced C-terminus from Neurospora crassa 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... 著者 Kallio, J.P, Ferrario, E, Stromland, O, Ziegler, M. 登録日 2023-06-29 公開日 2023-11-15 最終更新日 2024-11-06 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Novel Calcium-Binding Motif Stabilizes and Increases the Activity of Aspergillus fumigatus Ecto-NADase. Biochemistry, 62, 2023

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