PDB: 230764 件ウェブページステータス検索Chemie searchBIRD

---

6NKT	Ternary complex crystal structure of K289M variant of DNA polymerase Beta with beta-gamma difluoro analogue of dGTP 分子名称: 2'-DEOXY-5'-O-[({[DIFLUORO(PHOSPHONO)METHYL](HYDROXY)PHOSPHORYL}OXY)(HYDROXY)PHOSPHORYL]GUANOSINE, DNA (5'-D(*CP*CP*GP*AP*CP*CP*GP*CP*GP*CP*AP*TP*CP*AP*GP*C)-3'), DNA (5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*(DOC))-3'), ... 著者 Batra, V.K, Wilson, S.H. 登録日 2019-01-07 公開日 2020-01-08 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Revealing an Internal Stabilization Deficiency in the DNA Polymerase beta K289M Cancer Variant through the Combined Use of Chemical Biology and X-ray Crystallography. Biochemistry, 59, 2020
6NKY	Ternary complex crystal structure of K289M variant of DNA polymerase Beta with "hot-spot sequence" with beta-gamma CHF analogue of dGTP 分子名称: 2'-DEOXY-5'-O-[(R)-{[(R)-[(R)-FLUORO(PHOSPHONO)METHYL](HYDROXY)PHOSPHORYL]OXY}(HYDROXY)PHOSPHORYL]GUANOSINE, CHLORIDE ION, DNA (5'-D(*CP*CP*GP*AP*AP*CP*AP*AP*GP*CP*AP*TP*CP*AP*GP*C)-3'), ... 著者 Batra, V.K, Wilson, S.H. 登録日 2019-01-07 公開日 2020-01-08 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (2.094 Å) 主引用文献 Revealing an Internal Stabilization Deficiency in the DNA Polymerase beta K289M Cancer Variant through the Combined Use of Chemical Biology and X-ray Crystallography. Biochemistry, 59, 2020
8JOO	Crystal structure of cytochrome P450 IkaD from Streptomyces sp. ZJ306, in complex with the substrate ikarugamycin 分子名称: (1Z,3E,5S,7R,8R,10R,11R,12S,15R,16S,18Z,25S)-11-ethyl-2-hydroxy-10-methyl-21,26-diazapentacyclo[23.2.1.05,16.07,15.08,12]octacosa-1(2),3,13,18-tetraene-20,27,28-trione, Cytochrome P450, FORMIC ACID, ... 著者 Zhang, Y.L, Zhang, L.P, Zhang, C.S. 登録日 2023-06-08 公開日 2023-11-15 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (2.25 Å) 主引用文献 A Mechanistic Understanding of the Distinct Regio- and Chemoselectivity of Multifunctional P450s by Structural Comparison of IkaD and CftA Complexed with Common Substrates. Angew.Chem.Int.Ed.Engl., 62, 2023
6CQF	Crystal structure of HPK1 in complex an inhibitor G1858 分子名称: Mitogen-activated protein kinase kinase kinase kinase 1, N-{2-(3,3-difluoropyrrolidin-1-yl)-6-[(3R)-pyrrolidin-3-yl]pyrimidin-4-yl}-1-(propan-2-yl)-1H-pyrazolo[4,3-c]pyridin-6-amine 著者 Wu, P, Lehoux, I, Mortara, K, Franke, Y, Chan, B.K, Wang, W. 登録日 2018-03-15 公開日 2018-12-19 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (2.246 Å) 主引用文献 Hematopoietic Progenitor Kinase-1 Structure in a Domain-Swapped Dimer. Structure, 27, 2019
4FG7	Crystal structure of human calcium/calmodulin-dependent protein kinase I 1-293 in complex with ATP 分子名称: ADENOSINE-5'-TRIPHOSPHATE, Calcium/calmodulin-dependent protein kinase type 1 著者 Zha, M, Zhong, C, Ou, Y, Wang, J, Han, L, Ding, J. 登録日 2012-06-04 公開日 2013-01-23 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Crystal structures of human CaMKIalpha reveal insights into the regulation mechanism of CaMKI. Plos One, 7, 2012
5FQE	The details of glycolipid glycan hydrolysis by the structural analysis of a family 123 glycoside hydrolase from Clostridium perfringens 分子名称: (4S)-2-METHYL-2,4-PENTANEDIOL, BETA-N-ACETYLGALACTOSAMINIDASE, BROMIDE ION, ... 著者 Noach, I, Pluvinage, B, Laurie, C, Abe, K.T, Alteen, M, Vocadlo, D.J, Boraston, A.B. 登録日 2015-12-10 公開日 2016-03-30 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (1.53 Å) 主引用文献 The Details of Glycolipid Glycan Hydrolysis by the Structural Analysis of a Family 123 Glycoside Hydrolase from Clostridium Perfringens J.Mol.Biol., 428, 2016
6NKS	Ternary complex crystal structure of K289M variant of DNA polymerase Beta with beta-gamma CHF analog of dGTP 分子名称: 2'-DEOXY-5'-O-[(R)-{[(R)-[(R)-FLUORO(PHOSPHONO)METHYL](HYDROXY)PHOSPHORYL]OXY}(HYDROXY)PHOSPHORYL]GUANOSINE, CHLORIDE ION, DNA (5'-D(*CP*CP*GP*AP*CP*CP*GP*CP*GP*CP*AP*TP*CP*AP*GP*C)-3'), ... 著者 Batra, V.K, Wilson, S.H. 登録日 2019-01-07 公開日 2020-01-08 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (2.349 Å) 主引用文献 Revealing an Internal Stabilization Deficiency in the DNA Polymerase beta K289M Cancer Variant through the Combined Use of Chemical Biology and X-ray Crystallography. Biochemistry, 59, 2020
6NT9	Cryo-EM structure of the complex between human TBK1 and chicken STING 分子名称: Serine/threonine-protein kinase TBK1, Stimulator of interferon genes protein 著者 Shang, G, Zhang, C, Chen, Z.J, Bai, X, Zhang, X. 登録日 2019-01-28 公開日 2019-03-06 最終更新日 2024-03-20 実験手法 ELECTRON MICROSCOPY (3.3 Å) 主引用文献 Structural basis of STING binding with and phosphorylation by TBK1. Nature, 567, 2019
6NKW	Ternary complex crystal structure of DNA polymerase Beta with "hot-spot sequence" with beta-gamma-methylene dGTP 分子名称: 2'-DEOXY-5'-O-(HYDROXY{[HYDROXY(PHOSPHONOMETHYL)PHOSPHORYL]OXY}PHOSPHORYL)GUANOSINE, CHLORIDE ION, DNA (5'-D(*CP*CP*GP*AP*AP*CP*AP*AP*GP*CP*AP*TP*CP*AP*GP*C)-3'), ... 著者 Batra, V.K, Wilson, S.H. 登録日 2019-01-07 公開日 2020-01-08 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (1.98 Å) 主引用文献 Revealing an Internal Stabilization Deficiency in the DNA Polymerase beta K289M Cancer Variant through the Combined Use of Chemical Biology and X-ray Crystallography. Biochemistry, 59, 2020
5FQG	The details of glycolipid glycan hydrolysis by the structural analysis of a family 123 glycoside hydrolase from Clostridium perfringens 分子名称: 2-acetamido-2-deoxy-beta-D-galactopyranose-(1-3)-beta-D-galactopyranose, BETA-N-ACETYLGALACTOSAMINIDASE, FORMIC ACID 著者 Noach, I, Pluvinage, B, Laurie, C, Abe, K.T, Alteen, M, Vocadlo, D.J, Boraston, A.B. 登録日 2015-12-10 公開日 2016-03-30 最終更新日 2024-11-13 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 The Details of Glycolipid Glycan Hydrolysis by the Structural Analysis of a Family 123 Glycoside Hydrolase from Clostridium Perfringens J.Mol.Biol., 428, 2016
8EYY	Cryo-EM structure of 4 insulins bound full-length mouse IR mutant with physically decoupled alpha CTs (C684S/C685S/C687S, denoted as IR-3CS) Asymmetric conformation 2 分子名称: Insulin, Insulin receptor 著者 Li, J, Wu, J.Y, Hall, C, Bai, X.C, Choi, E. 登録日 2022-10-29 公開日 2022-11-09 最終更新日 2024-10-30 実験手法 ELECTRON MICROSCOPY (4.9 Å) 主引用文献 Molecular basis for the role of disulfide-linked alpha CTs in the activation of insulin-like growth factor 1 receptor and insulin receptor. Elife, 11, 2022
6CXH	Crystal structure of particulate methane monooxygenase from Methylomicrobium alcaliphilum 20Z 分子名称: 5-CYCLOHEXYL-1-PENTYL-BETA-D-MALTOSIDE, COPPER (II) ION, Particulate methane monooxygenase, ... 著者 Ro, S.Y, Rosenzweig, A.C. 登録日 2018-04-03 公開日 2018-05-16 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.704 Å) 主引用文献 From micelles to bicelles: Effect of the membrane on particulate methane monooxygenase activity. J. Biol. Chem., 293, 2018
8F2G	Crystal structure of Hen Egg White Lysozyme at 0.44 GPa 分子名称: Lysozyme C 著者 Marshall, A.C, Boer, S.A, Turner, G, Moggach, S.A, Bond, C.S, Vrielink, A. 登録日 2022-11-08 公開日 2022-12-07 最終更新日 2024-11-06 実験手法 X-RAY DIFFRACTION (1.84 Å) 主引用文献 High-pressure single-crystal diffraction at the Australian Synchrotron. J.Synchrotron Radiat., 30, 2023
7TWD	Structure of AAGAB C-terminal dimerization domain 分子名称: Alpha- and gamma-adaptin-binding protein p34, PHOSPHATE ION 著者 Tian, Y, Yin, Q. 登録日 2022-02-07 公開日 2023-01-18 最終更新日 2024-05-22 実験手法 X-RAY DIFFRACTION (2.11 Å) 主引用文献 Oligomer-to-monomer transition underlies the chaperone function of AAGAB in AP1/AP2 assembly. Proc.Natl.Acad.Sci.USA, 120, 2023
6ZXL	Fully-loaded anthrax lethal toxin in its heptameric pre-pore state and PA7LF(2+1A) arrangement 分子名称: Lethal factor, Protective antigen 著者 Quentin, D, Antoni, C, Gatsogiannis, C, Raunser, S. 登録日 2020-07-29 公開日 2020-09-02 最終更新日 2024-05-01 実験手法 ELECTRON MICROSCOPY (4.2 Å) 主引用文献 Cryo-EM structure of the fully-loaded asymmetric anthrax lethal toxin in its heptameric pre-pore state. Plos Pathog., 16, 2020
6NFU	Structure of the KcsA-G77A mutant or the 2,4-ion bound configuration of a K+ channel selectivity filter. 分子名称: (1S)-2-HYDROXY-1-[(NONANOYLOXY)METHYL]ETHYL MYRISTATE, NONAN-1-OL, POTASSIUM ION, ... 著者 Tilegenova, C, Cortes, D.M, Jahovic, N, Hardy, E, Parameswaran, H, Guan, L, Cuello, L.G. 登録日 2018-12-20 公開日 2019-08-07 最終更新日 2024-10-23 実験手法 X-RAY DIFFRACTION (2.09 Å) 主引用文献 Structure, function, and ion-binding properties of a K+channel stabilized in the 2,4-ion-bound configuration. Proc.Natl.Acad.Sci.USA, 116, 2019
4FDJ	The molecular basis of mucopolysaccharidosis IV A, complex with GalNAc 分子名称: 2-acetamido-2-deoxy-beta-D-galactopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... 著者 Rivera-Colon, Y, Garman, S.C. 登録日 2012-05-28 公開日 2012-09-05 最終更新日 2024-11-06 実験手法 X-RAY DIFFRACTION (2.81 Å) 主引用文献 The Structure of Human GALNS Reveals the Molecular Basis for Mucopolysaccharidosis IV A. J.Mol.Biol., 423, 2012
6NJU	Mouse endonuclease G mutant H97A bound to A-DNA 分子名称: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, CHLORIDE ION, DNA (5'-D(CCGGCGCCGG)-3'), ... 著者 Vander Zanden, C.M, Ho, E.N, Czarny, R.S, Robertson, A.B, Ho, P.S. 登録日 2019-01-04 公開日 2020-01-08 最終更新日 2024-10-09 実験手法 X-RAY DIFFRACTION (2.35 Å) 主引用文献 Structural adaptation of vertebrate endonuclease G for 5-hydroxymethylcytosine recognition and function. Nucleic Acids Res., 48, 2020
6NL0	Ternary complex crystal structure of K289M variant of DNA polymerase Beta with "hot-spot sequence" with beta-gamma CF2 analogue of dGTP 分子名称: 2'-DEOXY-5'-O-[({[DIFLUORO(PHOSPHONO)METHYL](HYDROXY)PHOSPHORYL}OXY)(HYDROXY)PHOSPHORYL]GUANOSINE, CHLORIDE ION, DNA (5'-D(*CP*CP*GP*AP*AP*CP*AP*AP*GP*CP*AP*TP*CP*AP*GP*C)-3'), ... 著者 Batra, V.K, Wilson, S.H. 登録日 2019-01-07 公開日 2020-01-08 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (1.97 Å) 主引用文献 Revealing an Internal Stabilization Deficiency in the DNA Polymerase beta K289M Cancer Variant through the Combined Use of Chemical Biology and X-ray Crystallography. Biochemistry, 59, 2020
4O06	1.15A Resolution Structure of the Proteasome Assembly Chaperone Nas2 PDZ Domain 分子名称: Probable 26S proteasome regulatory subunit p27, SULFATE ION, TETRAETHYLENE GLYCOL 著者 Lovell, S, Mehzabeen, N, Battaile, K.P, Singh, C.R, Chowdhury, W.Q, Geanes, E, Roelofs, J. 登録日 2013-12-13 公開日 2014-04-16 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (1.15 Å) 主引用文献 1.15 angstrom resolution structure of the proteasome-assembly chaperone Nas2 PDZ domain. Acta Crystallogr F Struct Biol Commun, 70, 2014
8G0P	Crystal structure of the human Ndc80:Nuf2 loop region 分子名称: Kinetochore protein NDC80 homolog, Kinetochore protein Nuf2 著者 Zahm, J.A, Jenni, S, Harrison, S.C. 登録日 2023-02-01 公開日 2023-03-29 最終更新日 2024-11-20 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Structure of the Ndc80 complex and its interactions at the yeast kinetochore-microtubule interface. Open Biology, 13, 2023
5ILQ	Crystal structure of truncated unliganded Aspartate Transcarbamoylase from Plasmodium falciparum 分子名称: Aspartate carbamoyltransferase, GLYCEROL, SULFATE ION 著者 Lunev, S, Bosch, S.S, Batista, F.D.A, Wrenger, C, Groves, M.R. 登録日 2016-03-04 公開日 2016-06-08 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Crystal structure of truncated aspartate transcarbamoylase from Plasmodium falciparum. Acta Crystallogr.,Sect.F, 72, 2016
1NZ2	K45E Variant of Horse Heart Myoglobin 分子名称: Myoglobin, PROTOPORPHYRIN IX CONTAINING FE, SULFATE ION 著者 Hunter, C.L, Maurus, R, Mauk, M.R, Lee, H, Raven, E.L, Tong, H, Nguyen, N, Smith, M, Brayer, G.D, Mauk, A.G. 登録日 2003-02-15 公開日 2003-04-08 最終更新日 2023-08-16 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Introduction and characterization of a functionally linked metal ion binding site at the exposed heme edge of myoglobin Proc.Natl.Acad.Sci.USA, 100, 2003
4O5E	Structure of human DNA polymerase complexed with N7MG in the template base paired with incoming non-hydrolyzable TTP 分子名称: 5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]thymidine, DNA (5'-D(*CP*CP*GP*AP*CP*(FMG)P*TP*CP*GP*CP*AP*TP*CP*AP*GP*C)-3'), DNA (5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*A)-3'), ... 著者 Koag, M.C, Lee, S. 登録日 2013-12-19 公開日 2014-07-02 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.532 Å) 主引用文献 Transition-state destabilization reveals how human DNA polymerase beta proceeds across the chemically unstable lesion N7-methylguanine. Nucleic Acids Res., 42, 2014
4O5K	Structure of human DNA polymerase complexed with N7MG in the template base paired with incoming non-hydrolyzable CTP 分子名称: 2'-deoxy-5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]cytidine, DNA (5'-D(*CP*CP*GP*AP*CP*(FMG)P*TP*CP*GP*CP*AP*TP*CP*AP*GP*C)-3'), DNA (5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*A)-3'), ... 著者 Koag, M.C, Lee, S. 登録日 2013-12-19 公開日 2014-07-02 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.058 Å) 主引用文献 Transition-state destabilization reveals how human DNA polymerase beta proceeds across the chemically unstable lesion N7-methylguanine. Nucleic Acids Res., 42, 2014

<362363364365366367368369370371372373374375376377>