PDB: 97138 件ウェブページステータス検索Chemie searchBIRD

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6N0P	BRAF in complex with N-(3-(2-(2-hydroxyethoxy)-6-morpholinopyridin-4-yl)-4-methylphenyl)-2-(trifluoromethyl)isonicotinamide (LXH254) 分子名称: N-{3-[2-(2-hydroxyethoxy)-6-(morpholin-4-yl)pyridin-4-yl]-4-methylphenyl}-2-(trifluoromethyl)pyridine-4-carboxamide, Serine/threonine-protein kinase B-raf 著者 Mamo, M, Appleton, B.A. 登録日 2018-11-07 公開日 2019-09-04 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (2.37 Å) 主引用文献 Design and Discovery ofN-(3-(2-(2-Hydroxyethoxy)-6-morpholinopyridin-4-yl)-4-methylphenyl)-2-(trifluoromethyl)isonicotinamide, a Selective, Efficacious, and Well-Tolerated RAF Inhibitor Targeting RAS Mutant Cancers: The Path to the Clinic. J.Med.Chem., 63, 2020
6N5W	Crystal structure of the Ca2+/CaM complex with independent peptides of Kv7.4 (KCNQ4) A & B domains 分子名称: CALCIUM ION, Calmodulin-1, Potassium voltage-gated channel subfamily KQT member 4 著者 Taylor, A.B, Archer, C.R, Shapiro, M.S. 登録日 2018-11-22 公開日 2019-03-13 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.15 Å) 主引用文献 A mutually induced conformational fit underlies Ca2+-directed interactions between calmodulin and the proximal C terminus of KCNQ4 K+channels. J. Biol. Chem., 294, 2019
6MQE	Vaccine-elicited NHP FP-targeting HIV neutralizing antibody DFPH-a.15 in complex with HIV fusion peptide (residue 512-519) 分子名称: DFPHa.15 antibody Fab heavy chain, DFPHa.15 antibody Fab light chain, HIV fusion peptide 著者 Xu, K, Wang, Y, Kwong, P.D. 登録日 2018-10-09 公開日 2019-07-31 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.459 Å) 主引用文献 Antibody Lineages with Vaccine-Induced Antigen-Binding Hotspots Develop Broad HIV Neutralization. Cell, 178, 2019
6MQS	Vaccine-elicited NHP FP-targeting HIV neutralizing antibody A12V163-a.01 in complex with HIV fusion peptide (residue 512-519) 分子名称: HIV fusion peptide residue 512-519, antibody A12V163-a.01 heavy chain, antibody A12V163-a.01 light chain 著者 Xu, K, Wang, Y, Kwong, P.D. 登録日 2018-10-10 公開日 2019-07-31 最終更新日 2019-11-13 実験手法 X-RAY DIFFRACTION (2.997 Å) 主引用文献 Antibody Lineages with Vaccine-Induced Antigen-Binding Hotspots Develop Broad HIV Neutralization. Cell, 178, 2019
6NCN	Fragment-based Discovery of an apoE4 Stabilizer 分子名称: 1-(3-chlorophenyl)cyclobutane-1-carboximidamide, Apolipoprotein E 著者 Jakob, C.G, Qiu, W. 登録日 2018-12-11 公開日 2019-04-17 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.82 Å) 主引用文献 Fragment-Based Discovery of an Apolipoprotein E4 (apoE4) Stabilizer. J.Med.Chem., 62, 2019
5NKL	Crystal structure of the large fragment of DNA polymerase I from Thermus Aquaticus in a closed ternary complex with the artificial base pair dDs-dPxTP 分子名称: ACETATE ION, DNA (5'-D(*AP*AP*AP*(DNU)P*GP*GP*CP*GP*CP*CP*GP*TP*GP*GP*TP*C)-3'), DNA (5'-D(*GP*AP*CP*CP*AP*CP*GP*GP*CP*GP*CP*(DOC))-3'), ... 著者 Betz, K, Marx, A, Diederichs, K, Hirao, I, Kimoto, M. 登録日 2017-03-31 公開日 2017-06-28 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Structural Basis for Expansion of the Genetic Alphabet with an Artificial Nucleobase Pair. Angew. Chem. Int. Ed. Engl., 56, 2017
1DYJ	ISOMORPHOUS CRYSTAL STRUCTURES OF ESCHERICHIA COLI DIHYDROFOLATE REDUCTASE COMPLEXED WITH FOLATE, 5-DEAZAFOLATE AND 5,10-DIDEAZATETRAHYDROFOLATE: MECHANISTIC IMPLICATIONS 分子名称: 5,10-DIDEAZATETRAHYDROFOLIC ACID, CALCIUM ION, CHLORIDE ION, ... 著者 Reyes, V.M, Kraut, J. 登録日 1994-10-26 公開日 1995-06-03 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (1.85 Å) 主引用文献 Isomorphous crystal structures of Escherichia coli dihydrofolate reductase complexed with folate, 5-deazafolate, and 5,10-dideazatetrahydrofolate: mechanistic implications. Biochemistry, 34, 1995
6NW0	Crystal Structure Desulfovibrio desulfuricans Nickel-Substituted Rubredoxin 分子名称: NICKEL (II) ION, Rubredoxin 著者 Slater, J.W, Marguet, S.C, Gray, M.E, Sotomayor, M, Shafaat, H.S. 登録日 2019-02-05 公開日 2019-08-14 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.85 Å) 主引用文献 The Power of the Secondary Sphere: Modulating Hydrogenase Activity in Nickel-Substituted Rubredoxin Acs Catalysis, 2019
6NF2	Cryo-EM structure of vaccine-elicited antibody 0PV-c.01 in complex with HIV-1 Env BG505 DS-SOSIP and antibodies VRC03 and PGT122 分子名称: 0PV-c.01 Heavy Chain, 0PV-c.01 Light Chain, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... 著者 Gorman, J, Kwong, P.D. 登録日 2018-12-18 公開日 2019-07-24 最終更新日 2020-07-29 実験手法 ELECTRON MICROSCOPY (3.7 Å) 主引用文献 Antibody Lineages with Vaccine-Induced Antigen-Binding Hotspots Develop Broad HIV Neutralization. Cell, 178, 2019
6NSS	TRK-A IN COMPLEX WITH LIGAND 6 分子名称: High affinity nerve growth factor receptor, N-(8-methyl-2-phenylimidazo[1,2-a]pyrazin-3-yl)-2-(10H-phenoxazin-10-yl)acetamide 著者 Subramanian, G, Brown, D.G. 登録日 2019-01-25 公開日 2019-05-22 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (1.97 Å) 主引用文献 Deciphering the Allosteric Binding Mechanism of the Human Tropomyosin Receptor Kinase A ( hTrkA) Inhibitors. Acs Chem.Biol., 14, 2019
6NCO	Fragment-based Discovery of an apoE4 Stabilizer 分子名称: 1-[5-chloro-4'-(2-hydroxypropan-2-yl)[1,1'-biphenyl]-3-yl]cyclobutane-1-carboximidamide, Apolipoprotein E 著者 Jakob, C.G, Qiu, W. 登録日 2018-12-11 公開日 2019-04-17 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.707 Å) 主引用文献 Fragment-Based Discovery of an Apolipoprotein E4 (apoE4) Stabilizer. J.Med.Chem., 62, 2019
5NWX	Insight into the molecular recognition mechanism of the coactivator NCoA1 by STAT6 分子名称: Nuclear receptor coactivator 1, Signal transducer and activator of transcription 6 著者 Russo, L, Giller, K, Pfitzner, E, Griesinger, C, Becker, S. 登録日 2017-05-08 公開日 2017-12-13 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (2.51 Å) 主引用文献 Insight into the molecular recognition mechanism of the coactivator NCoA1 by STAT6. Sci Rep, 7, 2017
1DYH	ISOMORPHOUS CRYSTAL STRUCTURES OF ESCHERICHIA COLI DIHYDROFOLATE REDUCTASE COMPLEXED WITH FOLATE, 5-DEAZAFOLATE AND 5,10-DIDEAZATETRAHYDROFOLATE: MECHANISTIC IMPLICATIONS 分子名称: 5-DEAZAFOLIC ACID, CALCIUM ION, CHLORIDE ION, ... 著者 Reyes, V.M, Kraut, J. 登録日 1994-10-26 公開日 1995-06-03 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Isomorphous crystal structures of Escherichia coli dihydrofolate reductase complexed with folate, 5-deazafolate, and 5,10-dideazatetrahydrofolate: mechanistic implications. Biochemistry, 34, 1995
1DYI	ISOMORPHOUS CRYSTAL STRUCTURES OF ESCHERICHIA COLI DIHYDROFOLATE REDUCTASE COMPLEXED WITH FOLATE, 5-DEAZAFOLATE AND 5,10-DIDEAZATETRAHYDROFOLATE: MECHANISTIC IMPLICATIONS 分子名称: CALCIUM ION, CHLORIDE ION, DIHYDROFOLATE REDUCTASE, ... 著者 Reyes, V.M, Kraut, J. 登録日 1994-10-26 公開日 1995-06-03 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Isomorphous crystal structures of Escherichia coli dihydrofolate reductase complexed with folate, 5-deazafolate, and 5,10-dideazatetrahydrofolate: mechanistic implications. Biochemistry, 34, 1995
6NW1	Crystal Structure Desulfovibrio desulfuricans Nickel-Substituted Rubredoxin V37N 分子名称: NICKEL (II) ION, Rubredoxin 著者 Slater, J.W, Marguet, S.C, Gray, M.E, Sotomayor, M, Shafaat, H.S. 登録日 2019-02-05 公開日 2019-08-14 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.86 Å) 主引用文献 The Power of the Secondary Sphere: Modulating Hydrogenase Activity in Nickel-Substituted Rubredoxin Acs Catalysis, 2019
1EBU	HOMOSERINE DEHYDROGENASE COMPLEX WITH NAD ANALOGUE AND L-HOMOSERINE 分子名称: 3-AMINOMETHYL-PYRIDINIUM-ADENINE-DINUCLEOTIDE, HOMOSERINE DEHYDROGENASE, L-HOMOSERINE, ... 著者 DeLaBarre, B, Thompson, P.R, Wright, G.D, Berghuis, A.M. 登録日 2000-01-24 公開日 2000-03-08 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Crystal structures of homoserine dehydrogenase suggest a novel catalytic mechanism for oxidoreductases. Nat.Struct.Biol., 7, 2000
6NPT	TRK-A IN COMPLEX WITH LIGAND 1 分子名称: 4-tert-butyl-N-(1,3-diphenyl-1H-pyrazol-5-yl)benzamide, High affinity nerve growth factor receptor 著者 Subramanian, G. 登録日 2019-01-18 公開日 2019-05-22 最終更新日 2019-07-10 実験手法 X-RAY DIFFRACTION (2.19 Å) 主引用文献 Deciphering the Allosteric Binding Mechanism of the Human Tropomyosin Receptor Kinase A ( hTrkA) Inhibitors. Acs Chem.Biol., 14, 2019
6NXE	Cryo-EM Reconstruction of Protease-Activateable Adeno-Associated Virus 9 (AAV9-L001) 分子名称: Capsid protein VP1 著者 Bennett, A.B, Agbandje-Mckenna, M. 登録日 2019-02-08 公開日 2019-03-13 最終更新日 2024-03-20 実験手法 ELECTRON MICROSCOPY (3.16 Å) 主引用文献 Protease-Activatable Adeno-Associated Virus Vector for Gene Delivery to Damaged Heart Tissue. Mol. Ther., 27, 2019
1XK5	Crystal structure of the m3G-cap-binding domain of snurportin1 in complex with a m3GpppG-cap dinucleotide 分子名称: 2,2,7-TRIMETHYL-GUANOSINE-5'-TRIPHOSPHATE-5'-GUANOSINE, snurportin-1 著者 Strasser, A, Dickmanns, A, Luehrmann, R, Ficner, R. 登録日 2004-09-27 公開日 2005-06-07 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Structural basis for m(3)G-cap-mediated nuclear import of spliceosomal UsnRNPs by snurportin1 Embo J., 24, 2005
376D	A ZIPPER-LIKE DNA DUPLEX D(GCGAAAGCT) 分子名称: COBALT HEXAMMINE(III), DNA (5'-D(*GP*(CBR)P*GP*AP*AP*AP*GP*CP*T)-3') 著者 Cruse, W.B.T, Shepard, W, Prange, T, delalFortelle, E, Fourme, R. 登録日 1998-01-22 公開日 1999-10-26 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 A zipper-like duplex in DNA: the crystal structure of d(GCGAAAGCT) at 2.1 A resolution. Structure, 6, 1998
4ZHL	The crystal structure of mupain-1-IG in complex with murinised human uPA at pH7.4 分子名称: Urokinase-type plasminogen activator, mupain-1-IG 著者 Jiang, L, Andreasen, P.A, Huang, M. 登録日 2015-04-25 公開日 2015-09-16 最終更新日 2015-10-14 実験手法 X-RAY DIFFRACTION (2.06 Å) 主引用文献 Selection of High-Affinity Peptidic Serine Protease Inhibitors with Increased Binding Entropy from a Back-Flip Library of Peptide-Protease Fusions. J.Mol.Biol., 427, 2015
8GPB	STRUCTURAL MECHANISM FOR GLYCOGEN PHOSPHORYLASE CONTROL BY PHOSPHORYLATION AND AMP 分子名称: ADENOSINE MONOPHOSPHATE, GLYCOGEN PHOSPHORYLASE B, PYRIDOXAL-5'-PHOSPHATE 著者 Barford, D, Hu, S.-H, Johnson, L.N. 登録日 1990-11-13 公開日 1992-10-15 最終更新日 2017-11-29 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Structural mechanism for glycogen phosphorylase control by phosphorylation and AMP. J.Mol.Biol., 218, 1991
2I0A	Crystal Structure of KB-19 complexed with wild type HIV-1 protease 分子名称: (5S)-3-(4-ACETYLPHENYL)-N-[(1S,2R)-1-BENZYL-2-HYDROXY-3-{ISOBUTYL[(4-METHOXYPHENYL)SULFONYL]AMINO}PROPYL]-2-OXO-1,3-OXAZOLIDINE-5-CARBOXAMIDE, GLYCEROL, PHOSPHATE ION, ... 著者 Nalam, M.N.L, Schiffer, C.A, Ali, A, Reddy, K.K, Cao, H, Anjum, S.G, Rana, T.M. 登録日 2006-08-10 公開日 2006-12-19 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Discovery of HIV-1 Protease Inhibitors with Picomolar Affinities Incorporating N-Aryl-oxazolidinone-5-carboxamides as Novel P2 Ligands. J.Med.Chem., 49, 2006
4NOX	Structure of the nine-bladed beta-propeller of eIF3b 分子名称: CHLORIDE ION, Eukaryotic translation initiation factor 3 subunit B 著者 Liu, Y, Neumann, P, Kuhle, B, Monecke, T, Ficner, R. 登録日 2013-11-20 公開日 2014-09-17 最終更新日 2024-03-20 実験手法 X-RAY DIFFRACTION (2.722 Å) 主引用文献 Translation initiation factor eIF3b contains a nine-bladed beta-propeller and interacts with the 40S ribosomal subunit Structure, 22, 2014
6ORT	Crystal Structure of Bos taurus Mxra8 Ectodomain 分子名称: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, CHLORIDE ION, Matrix remodeling-associated protein 8 著者 Fremont, D.H, Kim, A.S, Nelson, C.A, Center for Structural Genomics of Infectious Diseases (CSGID) 登録日 2019-04-30 公開日 2020-03-04 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 An Evolutionary Insertion in the Mxra8 Receptor-Binding Site Confers Resistance to Alphavirus Infection and Pathogenesis. Cell Host Microbe, 27, 2020

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