5NBD
 
 | | PglK flippase in complex with inhibitory nanobody | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, Nanobody, WlaB protein | | 著者 | Perez, C, Pardon, E, Steyaert, J, Locher, K.P. | | 登録日 | 2017-03-01 | | 公開日 | 2017-05-03 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (3.9 Å) | | 主引用文献 | Structural basis of inhibition of lipid-linked oligosaccharide flippase PglK by a conformational nanobody.
Sci Rep, 7, 2017
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6XXA
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5IZ9
 | | Protein-protein interaction | | 分子名称: | ACE-GLY-GLY-GLU-ALA-LEU-ALA-ASP-NH2, Adenomatous polyposis coli protein | | 著者 | Zhao, Y, Jiang, H, Yang, X, Jiang, F, Song, K, Zhang, J. | | 登録日 | 2016-03-25 | | 公開日 | 2017-07-05 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (2.93 Å) | | 主引用文献 | Peptidomimetic inhibitors of APC-Asef interaction block colorectal cancer migration.
Nat. Chem. Biol., 13, 2017
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6S1L
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6C5V
 | | An anti-gH/gL antibody that neutralizes dual-tropic infection defines a site of vulnerability on Epstein-Barr virus | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Antibody Fab AMMO1 heavy chain, Antibody Fab AMMO1 light chain, ... | | 著者 | Snijder, J, Ortego, M.S, Weidle, C, Stuart, A.B, Gray, M.A, McElrath, M.J, Pancera, M, Veesler, D, McGuire, A.T, Seattle Structural Genomics Center for Infectious Disease (SSGCID) | | 登録日 | 2018-01-16 | | 公開日 | 2018-05-02 | | 最終更新日 | 2020-07-29 | | 実験手法 | ELECTRON MICROSCOPY (4.8 Å) | | 主引用文献 | An Antibody Targeting the Fusion Machinery Neutralizes Dual-Tropic Infection and Defines a Site of Vulnerability on Epstein-Barr Virus.
Immunity, 48, 2018
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6RZN
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5N5Q
 | | Human TTR altered conformation from soaking in iron chloride. | | 分子名称: | ACETATE ION, FE (III) ION, Transthyretin, ... | | 著者 | Ciccone, L, Savko, M, Shepard, W, Stura, E.A. | | 登録日 | 2017-02-14 | | 公開日 | 2018-03-07 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (2.53 Å) | | 主引用文献 | Copper mediated amyloid-beta binding to Transthyretin.
Sci Rep, 8, 2018
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5J6C
 | | FMN-dependent Nitroreductase (CDR20291_0767) from Clostridium difficile R20291 | | 分子名称: | FLAVIN MONONUCLEOTIDE, IMIDAZOLE, Putative reductase | | 著者 | Powell, S.M, Wang, B, Hessami, N, Najar, F.Z, Thomas, L.M, West, A.H, Karr, E.A, Richter-Addo, G.B. | | 登録日 | 2016-04-04 | | 公開日 | 2016-09-21 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (2.096 Å) | | 主引用文献 | Crystal structures of two nitroreductases from hypervirulent Clostridium difficile and functionally related interactions with the antibiotic metronidazole.
Nitric Oxide, 60, 2016
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3NCB
 | | A mutant human Prolactin receptor antagonist H180A in complex with the extracellular domain of the human prolactin receptor | | 分子名称: | CARBONATE ION, CHLORIDE ION, Prolactin, ... | | 著者 | Kulkarni, M.V, Tettamanzi, M.C, Murphy, J.W, Keeler, C, Myszka, D.G, Chayen, N.E, Lolis, E.J, Hodsdon, M.E. | | 登録日 | 2010-06-04 | | 公開日 | 2010-09-29 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Two Independent Histidines, One in Human Prolactin and One in Its Receptor, Are Critical for pH-dependent Receptor Recognition and Activation.
J.Biol.Chem., 285, 2010
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5J83
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3NCF
 | | A mutant human Prolactin receptor antagonist H30A in complex with the mutant extracellular domain H188A of the human prolactin receptor | | 分子名称: | CHLORIDE ION, Prolactin, Prolactin receptor, ... | | 著者 | Kulkarni, M.V, Tettamanzi, M.C, Murphy, J.W, Keeler, C, Myszka, D.G, Chayen, N.E, Lolis, E.J, Hodsdon, M.E. | | 登録日 | 2010-06-04 | | 公開日 | 2010-09-29 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | Two Independent Histidines, One in Human Prolactin and One in Its Receptor, Are Critical for pH-dependent Receptor Recognition and Activation.
J.Biol.Chem., 285, 2010
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1FL1
 | | KSHV PROTEASE | | 分子名称: | POTASSIUM ION, PROTEASE | | 著者 | Reiling, K.K, Pray, T.R, Craik, C.S, Stroud, R.M. | | 登録日 | 2000-08-11 | | 公開日 | 2000-11-22 | | 最終更新日 | 2024-02-07 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Functional consequences of the Kaposi's sarcoma-associated herpesvirus protease structure: regulation of activity and dimerization by conserved structural elements.
Biochemistry, 39, 2000
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5JA2
 | | EntF, a Terminal Nonribosomal Peptide Synthetase Module Bound to the non-Native MbtH-Like Protein PA2412 | | 分子名称: | 5'-({[(2R,3S)-3-amino-4-hydroxy-2-{[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl]sulfanyl}butyl]sulfonyl}amino)-5'-deoxyadenosine, Enterobactin synthase component F, MbtH-Like Protein PA2412, ... | | 著者 | Miller, B.R, Gulick, A.M. | | 登録日 | 2016-04-11 | | 公開日 | 2016-09-14 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (3 Å) | | 主引用文献 | Structures of a Nonribosomal Peptide Synthetase Module Bound to MbtH-like Proteins Support a Highly Dynamic Domain Architecture.
J.Biol.Chem., 291, 2016
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6NFZ
 | | Crystal structure of diphosphorylated HPK1 kinase domain in complex with sunitinib in the active state. | | 分子名称: | Mitogen-activated protein kinase kinase kinase kinase 1, N-[2-(diethylamino)ethyl]-5-[(Z)-(5-fluoro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide | | 著者 | Johnson, E, McTigue, M, Cronin, C.N. | | 登録日 | 2018-12-21 | | 公開日 | 2019-05-01 | | 最終更新日 | 2019-06-26 | | 実験手法 | X-RAY DIFFRACTION (2.966 Å) | | 主引用文献 | Multiple conformational states of the HPK1 kinase domain in complex with sunitinib reveal the structural changes accompanying HPK1 trans-regulation.
J.Biol.Chem., 294, 2019
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6NHK
 | | Mortalin nucleotide binding domain in the ADP-bound state | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, GLYCEROL, MAGNESIUM ION, ... | | 著者 | Page, R.C, Moseng, M.A, Nix, J.C. | | 登録日 | 2018-12-23 | | 公開日 | 2019-04-17 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (2.777 Å) | | 主引用文献 | Biophysical Consequences of EVEN-PLUS Syndrome Mutations for the Function of Mortalin.
J.Phys.Chem.B, 123, 2019
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6NM5
 | | F-pilus/MS2 Maturation protein complex | | 分子名称: | (2R)-2,3-dihydroxypropyl ethyl hydrogen (S)-phosphate, Maturation protein, Type IV conjugative transfer system pilin TraA | | 著者 | Meng, R, Chang, J, Zhang, J. | | 登録日 | 2019-01-10 | | 公開日 | 2019-07-24 | | 最終更新日 | 2024-03-20 | | 実験手法 | ELECTRON MICROSCOPY (6.2 Å) | | 主引用文献 | Structural basis for the adsorption of a single-stranded RNA bacteriophage.
Nat Commun, 10, 2019
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6BQI
 | | Structure of two-domain translational regulator Yih1 reveals a possible mechanism of action | | 分子名称: | Protein IMPACT homolog | | 著者 | Harjes, E, Jameson, G.B, Edwards, P.J.B, Goroncy, A.K, Loo, T, Norris, G.E. | | 登録日 | 2017-11-27 | | 公開日 | 2018-11-28 | | 最終更新日 | 2024-05-15 | | 実験手法 | SOLUTION NMR, SOLUTION SCATTERING | | 主引用文献 | Experimentally based structural model of Yih1 provides insight into its function in controlling the key translational regulator Gcn2.
Febs Lett., 2020
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7ZW1
 | | Human PRPH2-ROM1 hetero-dimer | | 分子名称: | Nanobody, Peripherin-2, Rod outer segment membrane protein 1 | | 著者 | El Mazouni, D, Gros, P. | | 登録日 | 2022-05-17 | | 公開日 | 2022-11-16 | | 実験手法 | ELECTRON MICROSCOPY (3.7 Å) | | 主引用文献 | Cryo-EM structures of peripherin-2 and ROM1 suggest multiple roles in photoreceptor membrane morphogenesis.
Sci Adv, 8, 2022
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5MF5
 | | PA3825-EAL Mg-CdG Structure | | 分子名称: | 9,9'-[(2R,3R,3aS,5S,7aR,9R,10R,10aS,12S,14aR)-3,5,10,12-tetrahydroxy-5,12-dioxidooctahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9,2,8]tetraoxadiphosphacyclododecine-2,9-diyl]bis(2-amino-1,9-dihydro-6H-purin-6-one), Diguanylate phosphodiesterase, MAGNESIUM ION | | 著者 | Horrell, S, Bellini, D, Strange, R, Wagner, A, Walsh, M. | | 登録日 | 2016-11-17 | | 公開日 | 2016-12-21 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (1.77 Å) | | 主引用文献 | Dimerisation induced formation of the active site and the identification of three metal sites in EAL-phosphodiesterases.
Sci Rep, 7, 2017
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5IV1
 | | Solution Structure of DNA Dodecamer with 8-oxoguanine at 4th Position | | 分子名称: | DNA (5'-D(*CP*GP*CP*(8OG)P*AP*AP*TP*TP*CP*GP*CP*G)-3') | | 著者 | Miears, H.L, Gruber, D.R, Hoppins, J.J, Kiryutin, A.S, Kasymov, R.D, Yurkovskaya, A.V, Zharkov, D.O, Smirnov, S.L. | | 登録日 | 2016-03-18 | | 公開日 | 2016-07-27 | | 最終更新日 | 2024-05-01 | | 実験手法 | SOLUTION NMR | | 主引用文献 | 8-Oxoguanine Affects DNA Backbone Conformation in the EcoRI Recognition Site and Inhibits Its Cleavage by the Enzyme.
Plos One, 11, 2016
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6MY5
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8JOZ
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6MXS
 | | Crystal structure of the dimeric bH1-Fab variant [HC-Y33W,HC-D98F,HC-G99M] | | 分子名称: | 1,2-ETHANEDIOL, CHLORIDE ION, SODIUM ION, ... | | 著者 | Shi, R, Picard, M.-E, Manenda, M.S. | | 登録日 | 2018-10-31 | | 公開日 | 2019-07-31 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | | 主引用文献 | Binding symmetry and surface flexibility mediate antibody self-association.
Mabs, 11, 2019
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5IZ8
 | | Protein-protein interaction | | 分子名称: | ACE-ALA-GLY-GLU-ALA-LEU-ALA-ASP-NH2, Adenomatous polyposis coli protein, TRIETHYLENE GLYCOL | | 著者 | Zhao, Y, Jiang, H, Yang, X, Jiang, F, Song, K, Zhang, J. | | 登録日 | 2016-03-25 | | 公開日 | 2017-07-05 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (3.06 Å) | | 主引用文献 | Peptidomimetic inhibitors of APC-Asef interaction block colorectal cancer migration.
Nat. Chem. Biol., 13, 2017
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7FH1
 | | Structure of the human Meckelin | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Meckelin, beta-D-mannopyranose-(1-3)-[beta-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | | 著者 | Gong, D.S. | | 登録日 | 2021-07-29 | | 公開日 | 2021-12-01 | | 実験手法 | ELECTRON MICROSCOPY (3.34 Å) | | 主引用文献 | Structure of the human Meckel-Gruber protein Meckelin.
Sci Adv, 7, 2021
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