6NFZ

Crystal structure of diphosphorylated HPK1 kinase domain in complex with sunitinib in the active state.

Summary for 6NFZ

Entry DOI	10.2210/pdb6nfz/pdb
Descriptor	Mitogen-activated protein kinase kinase kinase kinase 1, N-[2-(diethylamino)ethyl]-5-[(Z)-(5-fluoro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide (2 entities in total)
Functional Keywords	kinase, active state, dimer, signaling protein
Biological source	Homo sapiens (Human)
Total number of polymer chains	2
Total formula weight	69986.55
Authors	Johnson, E.,McTigue, M.,Cronin, C.N. (deposition date: 2018-12-21, release date: 2019-05-01, Last modification date: 2019-06-26)
Primary citation	Johnson, E.,McTigue, M.,Gallego, R.A.,Johnson, T.W.,Timofeevski, S.,Maestre, M.,Fisher, T.S.,Kania, R.,Sawasdikosol, S.,Burakoff, S.,Cronin, C.N. Multiple conformational states of the HPK1 kinase domain in complex with sunitinib reveal the structural changes accompanying HPK1 trans-regulation. J.Biol.Chem., 294:9029-9036, 2019 Cited by PubMed: 31018963 DOI: 10.1074/jbc.AC119.007466 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.966 Å)

Structure validation