6NFZ
Crystal structure of diphosphorylated HPK1 kinase domain in complex with sunitinib in the active state.
Summary for 6NFZ
Entry DOI | 10.2210/pdb6nfz/pdb |
Descriptor | Mitogen-activated protein kinase kinase kinase kinase 1, N-[2-(diethylamino)ethyl]-5-[(Z)-(5-fluoro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide (2 entities in total) |
Functional Keywords | kinase, active state, dimer, signaling protein |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 69986.55 |
Authors | Johnson, E.,McTigue, M.,Cronin, C.N. (deposition date: 2018-12-21, release date: 2019-05-01, Last modification date: 2019-06-26) |
Primary citation | Johnson, E.,McTigue, M.,Gallego, R.A.,Johnson, T.W.,Timofeevski, S.,Maestre, M.,Fisher, T.S.,Kania, R.,Sawasdikosol, S.,Burakoff, S.,Cronin, C.N. Multiple conformational states of the HPK1 kinase domain in complex with sunitinib reveal the structural changes accompanying HPK1 trans-regulation. J.Biol.Chem., 294:9029-9036, 2019 Cited by PubMed: 31018963DOI: 10.1074/jbc.AC119.007466 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.966 Å) |
Structure validation
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