5N5Q

Human TTR altered conformation from soaking in iron chloride.

Summary for 5N5Q

• Entry DOI: 10.2210/pdb5n5q/pdb
• Related: 5K1J 5K1N
• Descriptor: Transthyretin, ACETATE ION, [bis(oxidanyl)-[tetrakis(oxidanyl)ferriooxy]ferrio]oxy-pentakis(oxidanyl)iron, ... (5 entities in total)
• Functional Keywords: conformational change, iron clusters, metal binding protein, alzheimer beta-amyloid scavenging, transport protein
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 26249.41

Authors

Ciccone, L.,Savko, M.,Shepard, W.,Stura, E.A. (deposition date: 2017-02-14, release date: 2018-03-07, Last modification date: 2024-01-17)

• Primary citation: Ciccone, L.,Fruchart-Gaillard, C.,Mourier, G.,Savko, M.,Nencetti, S.,Orlandini, E.,Servent, D.,Stura, E.A.,Shepard, W.; Copper mediated amyloid-beta binding to Transthyretin.; Sci Rep, 8:13744-13744, 2018; PubMed: 30213975; DOI: 10.1038/s41598-018-31808-5

Experimental method

X-RAY DIFFRACTION (2.53 Å)