6QPQ
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![BU of 6qpq by Molmil](/molmil-images/mine/6qpq) | |
8SF8
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![BU of 8sf8 by Molmil](/molmil-images/mine/8sf8) | Structure of bovine PKA bound to (R)-N-(4-(1H-pyrrolo[2,3-b]pyridin-4-yl)phenyl)-2-amino-4-methylpentanamide | 分子名称: | N-[4-(1H-pyrrolo[2,3-b]pyridin-4-yl)phenyl]-D-leucinamide, cAMP-dependent protein kinase catalytic subunit alpha, cAMP-dependent protein kinase inhibitor alpha | 著者 | Coker, J.A, Arya, T, Goins, C.M, Maw, J.J, Macdonald, J.D, Stauffer, S.R. | 登録日 | 2023-04-10 | 公開日 | 2024-02-21 | 最終更新日 | 2024-03-06 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Discovery and Characterization of Selective, First-in-Class Inhibitors of Citron Kinase. J.Med.Chem., 67, 2024
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5IEI
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![BU of 5iei by Molmil](/molmil-images/mine/5iei) | X-ray crystallographic structure of a high affinity IGF2 antagonist (Domain11 AB5 RHH) based on human IGF2R domain 11 | 分子名称: | 1,2-ETHANEDIOL, Cation-independent mannose-6-phosphate receptor, GLYCEROL, ... | 著者 | Nicholls, R.D, Williams, C, Strickland, M, Frago, S, Hassan, A.B, Crump, M.P. | 登録日 | 2016-02-25 | 公開日 | 2016-05-18 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Functional evolution of IGF2:IGF2R domain 11 binding generates novel structural interactions and a specific IGF2 antagonist. Proc.Natl.Acad.Sci.USA, 113, 2016
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8EJY
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![BU of 8ejy by Molmil](/molmil-images/mine/8ejy) | [4+2] Aza-Cyclase F293A variant | 分子名称: | PbtD | 著者 | Nair, S.K. | 登録日 | 2022-09-19 | 公開日 | 2022-11-23 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (2.47 Å) | 主引用文献 | Enzymatic Pyridine Aromatization during Thiopeptide Biosynthesis. J.Am.Chem.Soc., 144, 2022
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8EJZ
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![BU of 8ejz by Molmil](/molmil-images/mine/8ejz) | [4+2] Aza-Cyclase Y293F variant | 分子名称: | PbtD | 著者 | Nair, S.K. | 登録日 | 2022-09-19 | 公開日 | 2022-11-23 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Enzymatic Pyridine Aromatization during Thiopeptide Biosynthesis. J.Am.Chem.Soc., 144, 2022
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1CT1
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![BU of 1ct1 by Molmil](/molmil-images/mine/1ct1) | |
6QWU
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![BU of 6qwu by Molmil](/molmil-images/mine/6qwu) | 4'-phosphopantetheinyl transferase PptAb from Mycobacterium abscessus at pH 5.5 with Mn2+ and CoA. | 分子名称: | COENZYME A, DI(HYDROXYETHYL)ETHER, MANGANESE (II) ION, ... | 著者 | Nguyen, M.C, Mourey, L, Pedelacq, J.D. | 登録日 | 2019-03-06 | 公開日 | 2020-03-25 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.4 Å) | 主引用文献 | Conformational flexibility of coenzyme A and its impact on the post-translational modification of acyl carrier proteins by 4'-phosphopantetheinyl transferases. Febs J., 287, 2020
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8EQ9
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![BU of 8eq9 by Molmil](/molmil-images/mine/8eq9) | Co-crystal structure of PERK with compound 11 | 分子名称: | (2R)-N-[(4M)-4-(4-amino-7-methyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-3-methylphenyl]-2-(3-fluorophenyl)-2-hydroxyacetamide, Eukaryotic translation initiation factor 2-alpha kinase 3 | 著者 | Zhu, G, Surman, M.D, Mulvihill, M.J. | 登録日 | 2022-10-07 | 公開日 | 2022-11-30 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (2.86 Å) | 主引用文献 | Optimization of a Novel Mandelamide-Derived Pyrrolopyrimidine Series of PERK Inhibitors. Pharmaceutics, 14, 2022
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8EQD
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![BU of 8eqd by Molmil](/molmil-images/mine/8eqd) | Co-crystal structure of PERK with compound 24 | 分子名称: | (2R)-N-[(4M)-4-(4-amino-2,7-dimethyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-3-methylphenyl]-2-(3-fluorophenyl)-2-hydroxyacetamide, Eukaryotic translation initiation factor 2-alpha kinase 3 | 著者 | Zhu, G, Surman, M.D, Mulvihill, M.J. | 登録日 | 2022-10-07 | 公開日 | 2022-11-30 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (2.92 Å) | 主引用文献 | Optimization of a Novel Mandelamide-Derived Pyrrolopyrimidine Series of PERK Inhibitors. Pharmaceutics, 14, 2022
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8EQE
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![BU of 8eqe by Molmil](/molmil-images/mine/8eqe) | Co-crystal structure of PERK with compound 26 | 分子名称: | (2R)-N-[(4M)-4-(4-amino-2,7-dimethyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-3-methylphenyl]-2-hydroxy-2-[3-(trifluoromethyl)phenyl]acetamide, Eukaryotic translation initiation factor 2-alpha kinase 3 | 著者 | Zhu, G, Surman, M.D, Mulvihill, M.J. | 登録日 | 2022-10-07 | 公開日 | 2022-11-30 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (2.559 Å) | 主引用文献 | Optimization of a Novel Mandelamide-Derived Pyrrolopyrimidine Series of PERK Inhibitors. Pharmaceutics, 14, 2022
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6QXQ
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![BU of 6qxq by Molmil](/molmil-images/mine/6qxq) | |
5IRO
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![BU of 5iro by Molmil](/molmil-images/mine/5iro) | |
6QXR
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![BU of 6qxr by Molmil](/molmil-images/mine/6qxr) | 4'-phosphopantetheinyl transferase PptAb from Mycobacterium abscessus at pH 8.5 with Mn2+ and CoA. | 分子名称: | CALCIUM ION, COENZYME A, MANGANESE (II) ION, ... | 著者 | Nguyen, M.C, Mourey, L, Pedelacq, J.D. | 登録日 | 2019-03-07 | 公開日 | 2020-03-25 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.2 Å) | 主引用文献 | Conformational flexibility of coenzyme A and its impact on the post-translational modification of acyl carrier proteins by 4'-phosphopantetheinyl transferases. Febs J., 287, 2020
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5KLN
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![BU of 5kln by Molmil](/molmil-images/mine/5kln) | Crystal structure of 2-aminomuconate 6-semialdehyde dehydrogenase N169A in complex with NAD+ | 分子名称: | 2-aminomuconate 6-semialdehyde dehydrogenase, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, SODIUM ION | 著者 | Yang, Y, Davis, I, Ha, U, Wang, Y, Shin, I, Liu, A. | 登録日 | 2016-06-24 | 公開日 | 2016-11-09 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (1.992 Å) | 主引用文献 | A Pitcher-and-Catcher Mechanism Drives Endogenous Substrate Isomerization by a Dehydrogenase in Kynurenine Metabolism. J.Biol.Chem., 291, 2016
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5KLK
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![BU of 5klk by Molmil](/molmil-images/mine/5klk) | Crystal structure of 2-aminomuconate 6-semialdehyde dehydrogenase N169D in complex with NAD+ and 2-hydroxymuconate-6-semialdehyde | 分子名称: | (2E,4E)-2-hydroxy-6-oxohexa-2,4-dienoic acid, 2-aminomuconate 6-semialdehyde dehydrogenase, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, ... | 著者 | Yang, Y, Davis, I, Ha, U, Wang, Y, Shin, I, Liu, A. | 登録日 | 2016-06-24 | 公開日 | 2016-11-09 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2.006 Å) | 主引用文献 | A Pitcher-and-Catcher Mechanism Drives Endogenous Substrate Isomerization by a Dehydrogenase in Kynurenine Metabolism. J.Biol.Chem., 291, 2016
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8EZQ
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![BU of 8ezq by Molmil](/molmil-images/mine/8ezq) | |
1CHQ
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![BU of 1chq by Molmil](/molmil-images/mine/1chq) | |
1CHP
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5L84
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![BU of 5l84 by Molmil](/molmil-images/mine/5l84) | |
8EZJ
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6R7O
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![BU of 6r7o by Molmil](/molmil-images/mine/6r7o) | Crystal structure of the central region of human cohesin subunit STAG1 | 分子名称: | Cohesin subunit SA-1 | 著者 | Newman, J.A, katis, V.L, von Delft, F, Arrowsmith, C.H, Edwards, A, Bountra, C, Gileadi, O. | 登録日 | 2019-03-29 | 公開日 | 2019-04-10 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (2.31 Å) | 主引用文献 | STAG1 vulnerabilities for exploiting cohesin synthetic lethality in STAG2-deficient cancers. Life Sci Alliance, 3, 2020
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5LA1
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![BU of 5la1 by Molmil](/molmil-images/mine/5la1) | The mechanism by which arabinoxylanases can recognise highly decorated xylans | 分子名称: | CALCIUM ION, Carbohydrate binding family 6, TRIS-HYDROXYMETHYL-METHYL-AMMONIUM, ... | 著者 | Basle, A, Labourel, A, Cuskin, F, Jackson, A, Crouch, L, Rogowski, A, Gilbert, H. | 登録日 | 2016-06-13 | 公開日 | 2016-08-31 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | The Mechanism by Which Arabinoxylanases Can Recognize Highly Decorated Xylans. J.Biol.Chem., 291, 2016
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1BJZ
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5LA2
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![BU of 5la2 by Molmil](/molmil-images/mine/5la2) | The mechanism by which arabinoxylanases can recognise highly decorated xylans | 分子名称: | CALCIUM ION, Carbohydrate binding family 6, beta-D-xylopyranose-(1-4)-beta-D-xylopyranose-(1-4)-beta-D-xylopyranose-(1-4)-[alpha-L-arabinofuranose-(1-3)]alpha-D-xylopyranose, ... | 著者 | Basle, A, Labourel, A, Cuskin, F, Jackson, A, Crouch, L, Rogowski, A, Gilbert, H. | 登録日 | 2016-06-13 | 公開日 | 2016-08-31 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (1.65 Å) | 主引用文献 | The Mechanism by Which Arabinoxylanases Can Recognize Highly Decorated Xylans. J.Biol.Chem., 291, 2016
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5KZJ
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![BU of 5kzj by Molmil](/molmil-images/mine/5kzj) | Loop Deletion mutant of Paracoccus denitrificans AztC | 分子名称: | GLYCEROL, Periplasmic solute binding protein, ZINC ION | 著者 | Yukl, E. | 登録日 | 2016-07-25 | 公開日 | 2017-07-05 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Mechanisms of zinc binding to the solute-binding protein AztC and transfer from the metallochaperone AztD. J. Biol. Chem., 292, 2017
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