5KLK

Crystal structure of 2-aminomuconate 6-semialdehyde dehydrogenase N169D in complex with NAD+ and 2-hydroxymuconate-6-semialdehyde

Summary for 5KLK

Entry DOI	10.2210/pdb5klk/pdb
Related	5KLL 5KLM 5KLN 5KLO
Descriptor	2-aminomuconate 6-semialdehyde dehydrogenase, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, (2E,4E)-2-hydroxy-6-oxohexa-2,4-dienoic acid, ... (5 entities in total)
Functional Keywords	2-aminomuconate 6-semialdehyde dehydrogenase, kynurenine pathway, oxidoreductase
Biological source	Pseudomonas fluorescens
Total number of polymer chains	4
Total formula weight	227741.11
Authors	Yang, Y.,Davis, I.,Ha, U.,Wang, Y.,Shin, I.,Liu, A. (deposition date: 2016-06-24, release date: 2016-11-09, Last modification date: 2023-09-27)
Primary citation	Yang, Y.,Davis, I.,Ha, U.,Wang, Y.,Shin, I.,Liu, A. A Pitcher-and-Catcher Mechanism Drives Endogenous Substrate Isomerization by a Dehydrogenase in Kynurenine Metabolism. J.Biol.Chem., 291:26252-26261, 2016 Cited by PubMed: 27810899 DOI: 10.1074/jbc.M116.759712 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.006 Å)

Structure validation