5IEI
X-ray crystallographic structure of a high affinity IGF2 antagonist (Domain11 AB5 RHH) based on human IGF2R domain 11
Summary for 5IEI
Entry DOI | 10.2210/pdb5iei/pdb |
Related | 1GP0 2L29 2L2A 2M68 2M6T |
Descriptor | Cation-independent mannose-6-phosphate receptor, GLYCEROL, 1,2-ETHANEDIOL, ... (4 entities in total) |
Functional Keywords | igf2, igf2r, domain 11, transport protein |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 15963.11 |
Authors | Nicholls, R.D.,Williams, C.,Strickland, M.,Frago, S.,Hassan, A.B.,Crump, M.P. (deposition date: 2016-02-25, release date: 2016-05-18, Last modification date: 2024-01-10) |
Primary citation | Frago, S.,Nicholls, R.D.,Strickland, M.,Hughes, J.,Williams, C.,Garner, L.,Surakhy, M.,Maclean, R.,Rezgui, D.,Prince, S.N.,Zaccheo, O.J.,Ebner, D.,Sanegre, S.,Yu, S.,Buffa, F.M.,Crump, M.P.,Hassan, A.B. Functional evolution of IGF2:IGF2R domain 11 binding generates novel structural interactions and a specific IGF2 antagonist. Proc.Natl.Acad.Sci.USA, 113:E2766-E2775, 2016 Cited by PubMed: 27140600DOI: 10.1073/pnas.1513023113 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.8 Å) |
Structure validation
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