2M68
NMR solution structure ensemble of 3-4D mutant domain 11 IGF2R in complex with IGF2 (domain 11 structure only)
Summary for 2M68
Entry DOI | 10.2210/pdb2m68/pdb |
Related | 2CNJ 2L29 2L2A 2M6T |
NMR Information | BMRB: 19117 |
Descriptor | Insulin-like growth factor 2 receptor variant (1 entity in total) |
Functional Keywords | antitumor, directed evolution, high affinity, antitumor protein |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 1 |
Total formula weight | 15433.59 |
Authors | Strickland, M.,Williams, C.,Richards, E.,Minnall, L.,Crump, M.P.,Frago, S.,Hughes, J.,Garner, L.,Hoppe, H.,Rezgui, D.,Zaccheo, O.J.,Prince, S.N.,Hassan, A.B.,Whittaker, S. (deposition date: 2013-03-27, release date: 2014-10-15, Last modification date: 2023-06-14) |
Primary citation | Frago, S.,Nicholls, R.D.,Strickland, M.,Hughes, J.,Williams, C.,Garner, L.,Surakhy, M.,Maclean, R.,Rezgui, D.,Prince, S.N.,Zaccheo, O.J.,Ebner, D.,Sanegre, S.,Yu, S.,Buffa, F.M.,Crump, M.P.,Hassan, A.B. Functional evolution of IGF2:IGF2R domain 11 binding generates novel structural interactions and a specific IGF2 antagonist. Proc.Natl.Acad.Sci.USA, 113:E2766-E2775, 2016 Cited by PubMed: 27140600DOI: 10.1073/pnas.1513023113 PDB entries with the same primary citation |
Experimental method | SOLUTION NMR |
Structure validation
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