2L29

Complex structure of E4 mutant human IGF2R domain 11 bound to IGF-II

Summary for 2L29

• Entry DOI: 10.2210/pdb2l29/pdb
• Related: 1GP0 2CNJ 2L21 2L2A
• NMR Information: BMRB: 17127
• Descriptor: Insulin-like growth factor 2 receptor variant, Insulin-like growth factor II (2 entities in total)
• Functional Keywords: mannose 6 phosphate receptor, insulin-like growth factor 2, genomic imprinting, ligand trap, transport protein
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 2
• Total formula weight: 22919.00

Authors

Williams, C.,Hoppe, H.,Rezgui, D.,Strickland, M.,Frago, S.,Ellis, R.Z.,Wattana-Amorn, P.,Prince, S.N.,Zaccheo, O.J.,Forbes, B.,Jones, E.Y.,Crump, M.P.,Hassan, A.B. (deposition date: 2010-08-13, release date: 2012-02-15, Last modification date: 2023-06-14)

• Primary citation: Williams, C.,Hoppe, H.J.,Rezgui, D.,Strickland, M.,Forbes, B.E.,Grutzner, F.,Frago, S.,Ellis, R.Z.,Wattana-Amorn, P.,Prince, S.N.,Zaccheo, O.J.,Nolan, C.M.,Mungall, A.J.,Jones, E.Y.,Crump, M.P.,Hassan, A.B.; An exon splice enhancer primes IGF2:IGF2R binding site structure and function evolution.; Science, 338:1209-1213, 2012; PubMed: 23197533; DOI: 10.1126/science.1228633

Experimental method

SOLUTION NMR