2L29
Complex structure of E4 mutant human IGF2R domain 11 bound to IGF-II
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Insulin-like growth factor 2 receptor variant | polymer | 142 | 15434.5 | 1 | UniProt (Q59EZ3) Pfam (PF00878) UniProt (by SIFTS) (P11717) | Homo sapiens (human) | |
| 2 | B (B) | Insulin-like growth factor II | polymer | 67 | 7484.5 | 1 | UniProt (P01344) Pfam (PF00049) | Homo sapiens (human) | IGF-II, Somatomedin-A, Insulin-like growth factor II Ala-25 Del, Preptin |
Sequence modifications
A: 1508 - 1647 (UniProt: Q59EZ3)
| PDB | External Database | Details |
|---|---|---|
| Lys 1544 | Glu 1467 | engineered mutation |
| Ser 1545 | Lys 1468 | engineered mutation |
| Val 1547 | Leu 1470 | engineered mutation |
| Pro 1648 | - | expression tag |
| Glu 1649 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 22919.0 | |
| All* | Total formula weight | 22919.0 |
