2M68

NMR solution structure ensemble of 3-4D mutant domain 11 IGF2R in complex with IGF2 (domain 11 structure only)

Summary for 2M68

• Entry DOI: 10.2210/pdb2m68/pdb
• Related: 2CNJ 2L29 2L2A 2M6T
• NMR Information: BMRB: 19117
• Descriptor: Insulin-like growth factor 2 receptor variant (1 entity in total)
• Functional Keywords: antitumor, directed evolution, high affinity, antitumor protein
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 1
• Total formula weight: 15433.59

Authors

Strickland, M.,Williams, C.,Richards, E.,Minnall, L.,Crump, M.P.,Frago, S.,Hughes, J.,Garner, L.,Hoppe, H.,Rezgui, D.,Zaccheo, O.J.,Prince, S.N.,Hassan, A.B.,Whittaker, S. (deposition date: 2013-03-27, release date: 2014-10-15, Last modification date: 2023-06-14)

• Primary citation: Frago, S.,Nicholls, R.D.,Strickland, M.,Hughes, J.,Williams, C.,Garner, L.,Surakhy, M.,Maclean, R.,Rezgui, D.,Prince, S.N.,Zaccheo, O.J.,Ebner, D.,Sanegre, S.,Yu, S.,Buffa, F.M.,Crump, M.P.,Hassan, A.B.; Functional evolution of IGF2:IGF2R domain 11 binding generates novel structural interactions and a specific IGF2 antagonist.; Proc.Natl.Acad.Sci.USA, 113:E2766-E2775, 2016; PubMed: 27140600; DOI: 10.1073/pnas.1513023113

Experimental method

SOLUTION NMR