5IEI

X-ray crystallographic structure of a high affinity IGF2 antagonist (Domain11 AB5 RHH) based on human IGF2R domain 11

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Cation-independent mannose-6-phosphate receptor	polymer	142	15554.8	1	UniProt (P11717) Pfam (PF00878) In PDB	Homo sapiens (Human)	M6PR,300 kDa mannose 6-phosphate receptor,MPR 300,Insulin-like growth factor 2 receptor,Insulin-like growth factor II receptor,IGF-II receptor,M6P/IGF2 receptor,M6P/IGF2R
2	A	GLYCEROL	non-polymer		92.1	1	Chemie (GOL)
3	A	1,2-ETHANEDIOL	non-polymer		62.1	2	Chemie (EDO)
4	A	SULFATE ION	non-polymer		96.1	2	Chemie (SO4)

Sequence modifications

A: 1508 - 1649 (UniProt: P11717)

PDB	External Database	Details
Ala 1543	Ser 1543	engineered mutation
Lys 1544	Glu 1544	engineered mutation
Gly 1545	Lys 1545	engineered mutation
Trp 1546	Gly 1546	engineered mutation
Gly 1547	Leu 1547	engineered mutation
Arg 1569	Gln 1569	engineered mutation
His 1597	Pro 1597	engineered mutation
His 1602	Ser 1602	engineered mutation
Gly 1619	Arg 1619	variant
Leu 1648	Gln 1648	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	15554.8
Non-Polymers*	Number of molecules	5
	Total formula weight	408.4
All*	Total formula weight	15963.1

*Water molecules are not included.