5IEI
X-ray crystallographic structure of a high affinity IGF2 antagonist (Domain11 AB5 RHH) based on human IGF2R domain 11
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Cation-independent mannose-6-phosphate receptor | polymer | 142 | 15554.8 | 1 | UniProt (P11717) Pfam (PF00878) | Homo sapiens (Human) | M6PR,300 kDa mannose 6-phosphate receptor,MPR 300,Insulin-like growth factor 2 receptor,Insulin-like growth factor II receptor,IGF-II receptor,M6P/IGF2 receptor,M6P/IGF2R |
| 2 | B (A) | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
| 3 | C, D (A) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 2 | Chemie (EDO) | |||
| 4 | E, F (A) | SULFATE ION | non-polymer | 96.1 | 2 | Chemie (SO4) |
Sequence modifications
A: 1508 - 1649 (UniProt: P11717)
| PDB | External Database | Details |
|---|---|---|
| Ala 1543 | Ser 1543 | engineered mutation |
| Lys 1544 | Glu 1544 | engineered mutation |
| Gly 1545 | Lys 1545 | engineered mutation |
| Trp 1546 | Gly 1546 | engineered mutation |
| Gly 1547 | Leu 1547 | engineered mutation |
| Arg 1569 | Gln 1569 | engineered mutation |
| His 1597 | Pro 1597 | engineered mutation |
| His 1602 | Ser 1602 | engineered mutation |
| Gly 1619 | Arg 1619 | variant |
| Leu 1648 | Gln 1648 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 15554.8 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 408.4 | |
| All* | Total formula weight | 15963.1 |
