6MO7
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![BU of 6mo7 by Molmil](/molmil-images/mine/6mo7) | N-terminal bromodomain of human BRD2 with N-((4-(3-(N-cyclopentylsulfamoyl)-4-methylphenyl)-3-methylisoxazol-5-yl)methyl)acetamide inhibitor | 分子名称: | Bromodomain-containing protein 2, N-({4-[3-(cyclopentylsulfamoyl)-4-methylphenyl]-3-methyl-1,2-oxazol-5-yl}methyl)acetamide | 著者 | Lansdon, E.B, Newby, Z.E.R. | 登録日 | 2018-10-04 | 公開日 | 2019-01-23 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | 主引用文献 | Structure-guided discovery of a novel, potent, and orally bioavailable 3,5-dimethylisoxazole aryl-benzimidazole BET bromodomain inhibitor. Bioorg. Med. Chem., 27, 2019
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6MH1
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![BU of 6mh1 by Molmil](/molmil-images/mine/6mh1) | CRYSTAL STRUCTURE OF THE FIRST BROMODOMAIN OF HUMAN BRD4 IN COMPLEX WITH HU-10, A 1,4,5-Trisubstituted Imidazole Analogue | 分子名称: | 1,2-ETHANEDIOL, Bromodomain-containing protein 4, N-(3,5-dimethylphenyl)-4-[4-(4-fluorophenyl)-1-(piperidin-4-yl)-1H-imidazol-5-yl]pyrimidin-2-amine | 著者 | Zhu, J.-Y, Schonbrunn, E. | 登録日 | 2018-09-17 | 公開日 | 2019-08-07 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | Molecular Basis for the N-Terminal Bromodomain-and-Extra-Terminal-Family Selectivity of a Dual Kinase-Bromodomain Inhibitor. J.Med.Chem., 61, 2018
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6MYB
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3SXA
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3SXG
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6MR8
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![BU of 6mr8 by Molmil](/molmil-images/mine/6mr8) | D276G DNA polymerase beta substrate complex with templating adenine and incoming Fapy-dGTP analog | 分子名称: | 1,2-ETHANEDIOL, 1-[2-amino-5-(formylamino)-6-oxo-1,6-dihydropyrimidin-4-yl]-2,5-anhydro-1,3-dideoxy-6-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]oxy}phosphoryl]-D-ribo-hexitol, CALCIUM ION, ... | 著者 | Freudenthal, B.D, Smith, M.R, Wilson, S.H, Beard, W.A. | 登録日 | 2018-10-11 | 公開日 | 2019-01-30 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (1.897 Å) | 主引用文献 | A guardian residue hinders insertion of a Fapy•dGTP analog by modulating the open-closed DNA polymerase transition. Nucleic Acids Res., 47, 2019
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4ZQS
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3T43
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6MIP
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3SOR
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![BU of 3sor by Molmil](/molmil-images/mine/3sor) | Factor XIa in complex with a clorophenyl-tetrazole inhibitor | 分子名称: | CITRIC ACID, Coagulation factor XI, {4-[(N-{3-[5-chloro-2-(1H-tetrazol-1-yl)phenyl]propanoyl}-L-phenylalanyl)amino]phenyl}acetic acid | 著者 | Kazemier, B, Oubrie, A. | 登録日 | 2011-06-30 | 公開日 | 2012-04-11 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | High-resolution crystal structures of factor XIa coagulation factor in complex with nonbasic high-affinity synthetic inhibitors. Acta Crystallogr.,Sect.F, 68, 2012
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6ML4
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![BU of 6ml4 by Molmil](/molmil-images/mine/6ml4) | BTB24 Zinc Fingers 4-8 with 19+1mer DNA Oligonucleotide (Sequence 3) | 分子名称: | 1,2-ETHANEDIOL, DNA (5'-D(*AP*CP*GP*CP*AP*GP*GP*TP*CP*CP*TP*GP*GP*AP*CP*GP*AP*AP*GP*C)-3'), DNA (5'-D(*TP*GP*CP*TP*TP*CP*GP*TP*CP*CP*AP*GP*GP*AP*CP*CP*TP*GP*CP*G)-3'), ... | 著者 | Horton, J.R, Cheng, X, Ren, R. | 登録日 | 2018-09-26 | 公開日 | 2019-07-03 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (1.482 Å) | 主引用文献 | Structural basis of specific DNA binding by the transcription factor ZBTB24. Nucleic Acids Res., 47, 2019
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6MXW
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3QK1
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![BU of 3qk1 by Molmil](/molmil-images/mine/3qk1) | Crystal Structure of Enterokinase-like Trypsin Variant | 分子名称: | 1,2-ETHANEDIOL, BENZAMIDINE, CALCIUM ION, ... | 著者 | Schoepfel, M, Tziridis, A, Arnold, U, Stubbs, M.T. | 登録日 | 2011-01-31 | 公開日 | 2011-03-23 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (2.08 Å) | 主引用文献 | Towards a restriction proteinase: construction of a self-activating enzyme. Chembiochem, 12, 2011
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3QPZ
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![BU of 3qpz by Molmil](/molmil-images/mine/3qpz) | Crystal structure of the N59A mutant of the 3-deoxy-d-manno-octulosonate 8-phosphate synthase (KDO8PS) from Neisseria meningitidis | 分子名称: | 2-dehydro-3-deoxyphosphooctonate aldolase, CHLORIDE ION, GLYCEROL, ... | 著者 | Allison, T.M, Jameson, G.B, Parker, E.J, Cochrane, F.C. | 登録日 | 2011-02-14 | 公開日 | 2011-04-13 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | 主引用文献 | Targeting the role of a key conserved motif for substrate selection and catalysis by 3-deoxy-D-manno-octulosonate 8-phosphate synthase Biochemistry, 50, 2011
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3QMF
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![BU of 3qmf by Molmil](/molmil-images/mine/3qmf) | Crystal strucuture of an inositol monophosphatase family protein (SAS2203) from Staphylococcus aureus MSSA476 | 分子名称: | Inositol monophosphatase family protein, SULFATE ION | 著者 | Bhattacharyya, S, Dutta, D, Ghosh, A.K, Das, A.K. | 登録日 | 2011-02-04 | 公開日 | 2012-01-18 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Crystal structure of Staphylococcal dual specific inositol monophosphatase/NADP(H) phosphatase (SAS2203) delineates the molecular basis of substrate specificity Biochimie, 94, 2012
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3QE1
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2H9L
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![BU of 2h9l by Molmil](/molmil-images/mine/2h9l) | WDR5delta23 | 分子名称: | SULFATE ION, WD-repeat protein 5 | 著者 | Min, J.R, Schuetz, A, Allali-Hassani, A, Martin, F, Loppnau, P, Vedadi, M, Weigelt, J, Sundstrom, M, Edwards, A.M, Arrowsmith, C.H, Bochkarev, A, Plotnikov, A.N, Structural Genomics Consortium (SGC) | 登録日 | 2006-06-10 | 公開日 | 2006-08-01 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | 主引用文献 | Structural basis for molecular recognition and presentation of histone H3 By WDR5. Embo J., 25, 2006
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6NTJ
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![BU of 6ntj by Molmil](/molmil-images/mine/6ntj) | Neutron/X-ray crystal structure of AAC-VIa bound to gentamicin C1A | 分子名称: | (2R,3R,4R,5R)-2-((1S,2S,3R,4S,6R)-4,6-DIAMINO-3-((2R,3R,6S)-3-AMINO-6-(AMINOMETHYL)-TETRAHYDRO-2H-PYRAN-2-YLOXY)-2-HYDR OXYCYCLOHEXYLOXY)-5-METHYL-4-(METHYLAMINO)-TETRAHYDRO-2H-PYRAN-3,5-DIOL, Aminoglycoside N(3)-acetyltransferase, MAGNESIUM ION | 著者 | Cuneo, M.J, Kumar, P. | 登録日 | 2019-01-29 | 公開日 | 2019-09-25 | 最終更新日 | 2024-04-03 | 実験手法 | NEUTRON DIFFRACTION (1.9 Å), X-RAY DIFFRACTION | 主引用文献 | Low-Barrier and Canonical Hydrogen Bonds Modulate Activity and Specificity of a Catalytic Triad. Angew.Chem.Int.Ed.Engl., 58, 2019
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6NWB
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![BU of 6nwb by Molmil](/molmil-images/mine/6nwb) | PYL10 bound to the selective agonist hexabactin | 分子名称: | Abscisic acid receptor PYL10, N-{[(4-cyanophenyl)methyl]sulfonyl}-1-(thiophen-3-yl)cyclohexane-1-carboxamide | 著者 | Peterson, F.C, Vaidya, A, Jensen, D.R, Volkman, B.F, Cutler, S.R. | 登録日 | 2019-02-06 | 公開日 | 2020-02-12 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.003 Å) | 主引用文献 | PYL10 bound to the selective agonist hexabactin To Be Published
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6NUJ
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6NQZ
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![BU of 6nqz by Molmil](/molmil-images/mine/6nqz) | Flagellar protein FcpB from Leptospira interrogans | 分子名称: | 5-amino-2,4,6-triiodobenzene-1,3-dicarboxylic acid, Flagellar coiling protein B, GLYCEROL, ... | 著者 | Trajtenberg, F, Larrieux, N, Buschiazzo, A. | 登録日 | 2019-01-22 | 公開日 | 2020-01-29 | 最終更新日 | 2020-03-18 | 実験手法 | X-RAY DIFFRACTION (2.58 Å) | 主引用文献 | An asymmetric sheath controls flagellar supercoiling and motility in the Leptospira spirochete. Elife, 9, 2020
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6NXQ
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![BU of 6nxq by Molmil](/molmil-images/mine/6nxq) | Crystal structure of Arabidopsis thaliana cytosolic triosephosphate isomerase C13A mutant | 分子名称: | SODIUM ION, Triosephosphate isomerase, cytosolic | 著者 | Jimenez-Sandoval, P, Diaz-Quezada, C, Torres-Larios, A, Brieba, L.G. | 登録日 | 2019-02-09 | 公開日 | 2020-02-19 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (1.96 Å) | 主引用文献 | Structural basis for the modulation of plant cytosolic triosephosphate isomerase activity by mimicry of redox-based modifications. Plant J., 99, 2019
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3RN4
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![BU of 3rn4 by Molmil](/molmil-images/mine/3rn4) | Crystal structure of iron-substituted Sod2 from Saccharomyces cerevisiae | 分子名称: | FE (III) ION, Superoxide dismutase [Mn], mitochondrial | 著者 | Kang, Y, He, Y.-X, Cheng, W, Zhou, C.-Z, Li, W.-F. | 登録日 | 2011-04-21 | 公開日 | 2011-11-23 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (1.79 Å) | 主引用文献 | Structures of native and Fe-substituted SOD2 from Saccharomyces cerevisiae Acta Crystallogr.,Sect.F, 67, 2011
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3S6T
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![BU of 3s6t by Molmil](/molmil-images/mine/3s6t) | Crystal Structure of insect beta-N-acetyl-D-hexosaminidase OfHex1 V327G complexed with PUGNAc | 分子名称: | N-acetylglucosaminidase, O-(2-ACETAMIDO-2-DEOXY D-GLUCOPYRANOSYLIDENE) AMINO-N-PHENYLCARBAMATE | 著者 | Zhang, H, Liu, T, Yang, Q, Shen, X. | 登録日 | 2011-05-26 | 公開日 | 2012-04-11 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Active-pocket size differentiating insectile from bacterial chitinolytic beta-N-acetyl-D-hexosaminidases. Biochem.J., 438, 2011
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3SA1
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