6MR8

D276G DNA polymerase beta substrate complex with templating adenine and incoming Fapy-dGTP analog

Summary for 6MR8

• Entry DOI: 10.2210/pdb6mr8/pdb
• Related: 6DIA 6DIC 6MR7
• Descriptor: DNA polymerase beta, DNA (5'-D(*CP*CP*GP*AP*CP*AP*GP*CP*GP*CP*AP*TP*CP*AP*GP*C)-3'), DNA (5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*C)-3'), ... (9 entities in total)
• Functional Keywords: transferase activity, dna binding protein, dna binding protein-dna complex, dna binding protein/dna
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 4
• Total formula weight: 48455.29

Authors

Freudenthal, B.D.,Smith, M.R.,Wilson, S.H.,Beard, W.A. (deposition date: 2018-10-11, release date: 2019-01-30, Last modification date: 2023-10-11)

• Primary citation: Smith, M.R.,Shock, D.D.,Beard, W.A.,Greenberg, M.M.,Freudenthal, B.D.,Wilson, S.H.; A guardian residue hinders insertion of a Fapy•dGTP analog by modulating the open-closed DNA polymerase transition.; Nucleic Acids Res., 47:3197-3207, 2019; PubMed: 30649431; DOI: 10.1093/nar/gkz002

Experimental method

X-RAY DIFFRACTION (1.897 Å)