6MR8
D276G DNA polymerase beta substrate complex with templating adenine and incoming Fapy-dGTP analog
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | DNA polymerase beta | polymer | 335 | 38183.6 | 1 | UniProt (P06746) Pfam (PF14716) Pfam (PF10391) Pfam (PF14792) Pfam (PF14791) | Homo sapiens (Human) | |
| 2 | B (T) | DNA (5'-D(*CP*CP*GP*AP*CP*AP*GP*CP*GP*CP*AP*TP*CP*AP*GP*C)-3') | polymer | 16 | 4853.2 | 1 | synthetic construct | ||
| 3 | C (P) | DNA (5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*C)-3') | polymer | 10 | 3061.0 | 1 | synthetic construct | ||
| 4 | D (D) | DNA (5'-D(P*GP*TP*CP*GP*G)-3') | polymer | 5 | 1536.0 | 1 | synthetic construct | ||
| 5 | E (A) | 1-[2-amino-5-(formylamino)-6-oxo-1,6-dihydropyrimidin-4-yl]-2,5-anhydro-1,3-dideoxy-6-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]oxy}phosphoryl]-D-ribo-hexitol | non-polymer | 524.2 | 1 | Chemie (GKS) | |||
| 6 | F, G, H, I, M (A, T) | SODIUM ION | non-polymer | 23.0 | 5 | Chemie (NA) | |||
| 7 | J, K, L (A) | CALCIUM ION | non-polymer | 40.1 | 3 | Chemie (CA) | |||
| 8 | N (P) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 1 | Chemie (EDO) | |||
| 9 | O, P, Q, R (A, T, P, D) | water | water | 18.0 | 370 | Chemie (HOH) |
Sequence modifications
A: 11 - 335 (UniProt: P06746)
| PDB | External Database | Details |
|---|---|---|
| Gly 276 | Asp 276 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 47633.8 | |
| Non-Polymers* | Number of molecules | 10 |
| Total formula weight | 821.5 | |
| All* | Total formula weight | 48455.3 |
