6NTJ

Neutron/X-ray crystal structure of AAC-VIa bound to gentamicin C1A

Summary for 6NTJ

Entry DOI	10.2210/pdb6ntj/pdb
Descriptor	Aminoglycoside N(3)-acetyltransferase, (2R,3R,4R,5R)-2-((1S,2S,3R,4S,6R)-4,6-DIAMINO-3-((2R,3R,6S)-3-AMINO-6-(AMINOMETHYL)-TETRAHYDRO-2H-PYRAN-2-YLOXY)-2-HYDR OXYCYCLOHEXYLOXY)-5-METHYL-4-(METHYLAMINO)-TETRAHYDRO-2H-PYRAN-3,5-DIOL, MAGNESIUM ION, ... (4 entities in total)
Functional Keywords	acetyl transferase, neutron, transferase, transferase-antibiotic complex, transferase/antibiotic
Biological source	Enterobacteriaceae
Total number of polymer chains	1
Total formula weight	32804.28
Authors	Cuneo, M.J.,Kumar, P. (deposition date: 2019-01-29, release date: 2019-09-25, Last modification date: 2024-04-03)
Primary citation	Kumar, P.,Agarwal, P.K.,Waddell, M.B.,Mittag, T.,Serpersu, E.H.,Cuneo, M.J. Low-Barrier and Canonical Hydrogen Bonds Modulate Activity and Specificity of a Catalytic Triad. Angew.Chem.Int.Ed.Engl., 58:16260-16266, 2019 Cited by PubMed: 31515870 DOI: 10.1002/anie.201908535 PDB entries with the same primary citation
Experimental method	NEUTRON DIFFRACTION (2.35 Å) X-RAY DIFFRACTION (1.9 Å)

Structure validation