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3SOR

Factor XIa in complex with a clorophenyl-tetrazole inhibitor

Summary for 3SOR
Entry DOI10.2210/pdb3sor/pdb
DescriptorCoagulation factor XI, CITRIC ACID, {4-[(N-{3-[5-chloro-2-(1H-tetrazol-1-yl)phenyl]propanoyl}-L-phenylalanyl)amino]phenyl}acetic acid, ... (4 entities in total)
Functional Keywordshydrolase, serine protease, coagulation factor, syntethic inhibitor, blood, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological sourceHomo sapiens (human)
Cellular locationSecreted: P03951
Total number of polymer chains1
Total formula weight27581.60
Authors
Kazemier, B.,Oubrie, A. (deposition date: 2011-06-30, release date: 2012-04-11, Last modification date: 2013-01-23)
Primary citationFradera, X.,Kazemier, B.,Carswell, E.,Cooke, A.,Oubrie, A.,Hamilton, W.,Dempster, M.,Krapp, S.,Nagel, S.,Jestel, A.
High-resolution crystal structures of factor XIa coagulation factor in complex with nonbasic high-affinity synthetic inhibitors.
Acta Crystallogr.,Sect.F, 68:404-408, 2012
Cited by
PubMed: 22505407
DOI: 10.1107/S1744309112009037
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.8 Å)
Structure validation

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