3SOR
Factor XIa in complex with a clorophenyl-tetrazole inhibitor
Summary for 3SOR
Entry DOI | 10.2210/pdb3sor/pdb |
Descriptor | Coagulation factor XI, CITRIC ACID, {4-[(N-{3-[5-chloro-2-(1H-tetrazol-1-yl)phenyl]propanoyl}-L-phenylalanyl)amino]phenyl}acetic acid, ... (4 entities in total) |
Functional Keywords | hydrolase, serine protease, coagulation factor, syntethic inhibitor, blood, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Secreted: P03951 |
Total number of polymer chains | 1 |
Total formula weight | 27581.60 |
Authors | Kazemier, B.,Oubrie, A. (deposition date: 2011-06-30, release date: 2012-04-11, Last modification date: 2013-01-23) |
Primary citation | Fradera, X.,Kazemier, B.,Carswell, E.,Cooke, A.,Oubrie, A.,Hamilton, W.,Dempster, M.,Krapp, S.,Nagel, S.,Jestel, A. High-resolution crystal structures of factor XIa coagulation factor in complex with nonbasic high-affinity synthetic inhibitors. Acta Crystallogr.,Sect.F, 68:404-408, 2012 Cited by PubMed: 22505407DOI: 10.1107/S1744309112009037 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.8 Å) |
Structure validation
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