PDB: 2013 件ウェブページステータス検索Chemie searchBIRD

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6FS6	Influenza A/California/04/2009 (pH1N1) endonuclease with bound inhibitor, baloxavir acid (BXA) 分子名称: Baloxavir acid, MANGANESE (II) ION, Polymerase acidic protein,Polymerase acidic protein 著者 Cusack, S, Speranzini, V. 登録日 2018-02-19 公開日 2018-07-11 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (2.291 Å) 主引用文献 Characterization of influenza virus variants induced by treatment with the endonuclease inhibitor baloxavir marboxil. Sci Rep, 8, 2018
6CFP	CRYSTAL STRUCTURE OF POLYMERASE ACID PROTEIN (PA) FROM INFLUENZA A VIRUS, WILSON-SMITH/1933 (H1N1) BOUND TO FRAGMENT HIT BSI-70565 1-{1-[4-FLUOROPHENYL)METHYL]-2-METHYL-1H-IMIDAZOL-4-YL}ETHAN-1-ONE 分子名称: 1-{1-[(4-fluorophenyl)methyl]-2-methyl-1H-imidazol-4-yl}ethan-1-one, DIMETHYL SULFOXIDE, Ubiquitin-like protein SMT3,Polymerase acidic protein 著者 Seattle Structural Genomics Center for Infectious Disease (SSGCID) 登録日 2018-02-15 公開日 2018-04-11 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.45 Å) 主引用文献 CRYSTAL STRUCTURE OF POLYMERASE ACID PROTEIN (PA) FROM INFLUENZA A VIRUS, WILSON-SMITH/1933 (H1N1) BOUND TO FRAGMENT HIT BSI-70565 1-{1-[4-FLUOROPHENYL)METHYL]-2-METHYL-1H-IMIDAZOL-4-YL}ETHAN-1-ONE To Be Published
6FHH	Crystal structure of bat influenza A/H17N10 polymerase with viral RNA promoter bound to a 22-mer modified Pol II CTD peptide with serine 5 thiophosphorylated. 分子名称: PHOSPHATE ION, Polymerase acidic protein, Polymerase basic protein 2, ... 著者 Lukarska, M, Cusack, S. 登録日 2018-01-14 公開日 2019-01-30 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Towards New Anti-Influenza Therapeutics: Structure-Activity Relationships in the Interaction between Heterotrimeric Influenza Polymerase and Pol II C-terminal domain To Be Published
6FHI	Crystal structure of bat influenza A/H17N10 polymerase with viral RNA promoter bound to a 19-mer serine 5 phosphorylated Pol II CTD peptide with a truncated linker. 分子名称: PHOSPHATE ION, Polymerase acidic protein, Polymerase basic protein 2, ... 著者 Lukarska, M, Cusack, S. 登録日 2018-01-14 公開日 2019-01-30 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Towards New Anti-Influenza Therapeutics: Structure-Activity Relationships in the Interaction between Heterotrimeric Influenza Polymerase and Pol II C-terminal domain To Be Published
6FFS	Structure-based design and synthesis of macrocyclic human rhinovirus 3C protease inhibitors 分子名称: 3C Protease, SULFATE ION, ~{N}-[(2~{S},5~{S},14~{S})-2-[(4-fluorophenyl)methyl]-5-(hydroxymethyl)-9-methyl-3,8,15-tris(oxidanylidene)-1,4,9-triazacyclopentadec-14-yl]-5-methyl-1,2-oxazole-3-carboxamide 著者 Wiesmann, C, Farady, C. 登録日 2018-01-09 公開日 2018-02-21 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (1.86 Å) 主引用文献 Structure-based design and synthesis of macrocyclic human rhinovirus 3C protease inhibitors. Bioorg. Med. Chem. Lett., 28, 2018
6FFN	Structure-based design and synthesis of macrocyclic human rhinovirus 3C protease inhibitors 分子名称: 3C protease, DIMETHYL SULFOXIDE, GLYCEROL, ... 著者 Wiesmann, C, Farady, C. 登録日 2018-01-08 公開日 2018-02-21 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (1.75 Å) 主引用文献 Structure-based design and synthesis of macrocyclic human rhinovirus 3C protease inhibitors. Bioorg. Med. Chem. Lett., 28, 2018
6FFA	FMDV Leader protease bound to substrate ISG15 分子名称: GLYCEROL, Lbpro, SULFATE ION, ... 著者 Swatek, K.N, Pruneda, J.N, Komander, D. 登録日 2018-01-05 公開日 2018-02-21 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (1.5 Å) 主引用文献 Irreversible inactivation of ISG15 by a viral leader protease enables alternative infection detection strategies. Proc. Natl. Acad. Sci. U.S.A., 115, 2018
6BU8	70S ribosome with S1 domains 1 and 2 (Class 1) 分子名称: 16S ribosomal RNA, 23S ribosomal RNA, 30S ribosomal protein S1, ... 著者 Loveland, A.B, Korostelev, A.A. 登録日 2017-12-08 公開日 2018-01-31 最終更新日 2020-01-01 実験手法 ELECTRON MICROSCOPY (3.5 Å) 主引用文献 Structural dynamics of protein S1 on the 70S ribosome visualized by ensemble cryo-EM. Methods, 137, 2018
6F5O	A mechanism for the activation of the influenza virus transcriptase 分子名称: 3' promoter vRNA, 5' promoter vRNA, Polymerase acidic protein, ... 著者 Serna Martin, I, Grimes, J.M. 登録日 2017-12-02 公開日 2018-06-27 最終更新日 2024-05-15 実験手法 ELECTRON MICROSCOPY (9.8 Å) 主引用文献 A Mechanism for the Activation of the Influenza Virus Transcriptase. Mol. Cell, 70, 2018
6F5P	A mechanism for the activation of the influenza virus transcriptase 分子名称: ALA-ALA-ALA-ALA-ALA-ALA-ALA-ALA-ALA-ALA, DNA-directed RNA polymerase subunit, MAGNESIUM ION, ... 著者 Serna Martin, I, Grimes, J.M. 登録日 2017-12-02 公開日 2018-09-19 実験手法 X-RAY DIFFRACTION (4.14 Å) 主引用文献 A Mechanism for the Activation of the Influenza Virus Transcriptase. Mol. Cell, 70, 2018
6F42	RNA Polymerase III closed complex CC1. 分子名称: DNA-directed RNA polymerase III subunit RPC1, DNA-directed RNA polymerase III subunit RPC10, DNA-directed RNA polymerase III subunit RPC2, ... 著者 Vorlaender, M.K, Khatter, H, Wetzel, R, Hagen, W.J.H, Mueller, C.W. 登録日 2017-11-29 公開日 2018-01-17 最終更新日 2024-05-15 実験手法 ELECTRON MICROSCOPY (5.5 Å) 主引用文献 Molecular mechanism of promoter opening by RNA polymerase III. Nature, 553, 2018
6F41	RNA Polymerase III initially transcribing complex 分子名称: DNA-directed RNA polymerase III subunit RPC1, DNA-directed RNA polymerase III subunit RPC10, DNA-directed RNA polymerase III subunit RPC2, ... 著者 Vorlaender, M.K, Khatter, H, Wetzel, R, Hagen, W.J.H, Mueller, C.W. 登録日 2017-11-29 公開日 2018-01-17 最終更新日 2024-05-15 実験手法 ELECTRON MICROSCOPY (4.3 Å) 主引用文献 Molecular mechanism of promoter opening by RNA polymerase III. Nature, 553, 2018
6F40	RNA Polymerase III open complex 分子名称: DNA-directed RNA polymerase III subunit RPC1, DNA-directed RNA polymerase III subunit RPC10, DNA-directed RNA polymerase III subunit RPC2, ... 著者 Vorlaender, M.K, Khatter, H, Wetzel, R, Hagen, W.J.H, Mueller, C.W. 登録日 2017-11-29 公開日 2018-01-17 最終更新日 2024-05-15 実験手法 ELECTRON MICROSCOPY (3.7 Å) 主引用文献 Molecular mechanism of promoter opening by RNA polymerase III. Nature, 553, 2018
6F44	RNA Polymerase III closed complex CC2. 分子名称: DNA-directed RNA polymerase III subunit RPC1, DNA-directed RNA polymerase III subunit RPC10, DNA-directed RNA polymerase III subunit RPC2, ... 著者 Vorlaender, M.K, Khatter, H, Wetzel, R, Hagen, W.J.H, Mueller, C.W. 登録日 2017-11-29 公開日 2018-01-17 最終更新日 2024-05-15 実験手法 ELECTRON MICROSCOPY (4.2 Å) 主引用文献 Molecular mechanism of promoter opening by RNA polymerase III. Nature, 553, 2018
6BQF	Pol II elongation complex with 'dT-AP' at i+1, i-1 position 分子名称: DNA (5'-D(P*CP*TP*(3DR)P*CP*TP*CP*TP*TP*GP*AP*TP*G)-3'), DNA-directed RNA polymerase II subunit RPB1, DNA-directed RNA polymerase II subunit RPB11, ... 著者 Wang, W, Wang, D. 登録日 2017-11-27 公開日 2018-02-28 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (3.35 Å) 主引用文献 Structural basis of transcriptional stalling and bypass of abasic DNA lesion by RNA polymerase II. Proc. Natl. Acad. Sci. U.S.A., 115, 2018
6EZE	The open conformation of E.coli Elongation Factor Tu in complex with GDPNP. 分子名称: DI(HYDROXYETHYL)ETHER, Elongation factor Tu 2, GLYCEROL, ... 著者 Johansen, J.S, Blaise, M, Thirup, S.S. 登録日 2017-11-15 公開日 2018-08-22 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (2.47 Å) 主引用文献 E. coli elongation factor Tu bound to a GTP analogue displays an open conformation equivalent to the GDP-bound form. Nucleic Acids Res., 46, 2018
6BM4	Pol II elongation complex with an abasic lesion at i-1 position,soaking UMPNPP 分子名称: 5'-O-[(S)-hydroxy{[(S)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]uridine, DNA (5'-D(P*CP*AP*(3DR)P*CP*TP*CP*TP*TP*GP*AP*TP*G)-3'), DNA-directed RNA polymerase II subunit RPB1, ... 著者 Wang, W, Wang, D. 登録日 2017-11-13 公開日 2018-02-28 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (2.951 Å) 主引用文献 Structural basis of transcriptional stalling and bypass of abasic DNA lesion by RNA polymerase II. Proc. Natl. Acad. Sci. U.S.A., 115, 2018
6BM2	Pol II elongation complex with an abasic lesion at i-1 position 分子名称: DNA (5'-D(P*CP*AP*(3DR)P*CP*TP*CP*TP*TP*GP*AP*TP*G)-3'), DNA-directed RNA polymerase II subunit RPB1, DNA-directed RNA polymerase II subunit RPB11, ... 著者 Wang, W, Wang, D. 登録日 2017-11-13 公開日 2018-02-28 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (3.403 Å) 主引用文献 Structural basis of transcriptional stalling and bypass of abasic DNA lesion by RNA polymerase II. Proc. Natl. Acad. Sci. U.S.A., 115, 2018
6BLP	Pol II elongation complex with an abasic lesion at i+1 position, soaking AMPCPP 分子名称: DIPHOSPHOMETHYLPHOSPHONIC ACID ADENOSYL ESTER, DNA (5'-D(P*AP*(3DR)P*CP*TP*CP*TP*CP*GP*AP*TP*G)-3'), DNA-directed RNA polymerase II subunit RPB1, ... 著者 Wang, W, Wang, D. 登録日 2017-11-11 公開日 2018-02-28 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (3.203 Å) 主引用文献 Structural basis of transcriptional stalling and bypass of abasic DNA lesion by RNA polymerase II. Proc. Natl. Acad. Sci. U.S.A., 115, 2018
6BLO	Pol II elongation complex with an abasic lesion at i+1 position 分子名称: DNA (5'-D(P*AP*(3DR)P*CP*TP*CP*TP*CP*GP*AP*TP*G)-3'), DNA-directed RNA polymerase II subunit RPB1, DNA-directed RNA polymerase II subunit RPB11, ... 著者 Wang, W, Wang, D. 登録日 2017-11-10 公開日 2018-02-28 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (3.401 Å) 主引用文献 Structural basis of transcriptional stalling and bypass of abasic DNA lesion by RNA polymerase II. Proc. Natl. Acad. Sci. U.S.A., 115, 2018
6EXV	Structure of mammalian RNA polymerase II elongation complex inhibited by Alpha-amanitin 分子名称: AMATOXIN, DNA (25-MER), DNA (36-MER), ... 著者 Liu, X, Farnung, L, Wigge, C, Cramer, P. 登録日 2017-11-09 公開日 2018-03-21 最終更新日 2019-12-11 実験手法 ELECTRON MICROSCOPY (3.6 Å) 主引用文献 Cryo-EM structure of a mammalian RNA polymerase II elongation complex inhibited by alpha-amanitin. J. Biol. Chem., 293, 2018
6BJY	VSV Nucleocapsid with Polyamide Bound 分子名称: 4-{[4-(acetylamino)-1-methyl-1H-pyrrole-2-carbonyl]amino}-1-methyl-N-{4-[(1-methyl-1H-pyrrol-3-yl)amino]-4-oxobutyl}-1H-imidazole-2-carboxamide, Nucleoprotein, RNA (45-MER), ... 著者 Gumpper, R.H, Luo, M. 登録日 2017-11-07 公開日 2018-02-28 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (3.46 Å) 主引用文献 A Polyamide Inhibits Replication of Vesicular Stomatitis Virus by Targeting RNA in the Nucleocapsid. J. Virol., 92, 2018
6EVJ	Crystal structure of bat influenza A/H17N10 polymerase with viral RNA promoter and capped RNA primer 分子名称: Polymerase acidic protein, Polymerase basic protein 2, RNA (5'-D(*(GDM))-R(P*AP*AP*U)-3'), ... 著者 Pflug, A, Cusack, S. 登録日 2017-11-01 公開日 2017-12-13 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (3.9 Å) 主引用文献 Capped RNA primer binding to influenza polymerase and implications for the mechanism of cap-binding inhibitors. Nucleic Acids Res., 46, 2018
6EVK	Crystal structure of bat influenza A/H17N10 polymerase with viral RNA promoter and cap analogue m7GTP 分子名称: 7-METHYL-GUANOSINE-5'-TRIPHOSPHATE, PHOSPHATE ION, Polymerase acidic protein, ... 著者 Pflug, A, Cusack, S. 登録日 2017-11-01 公開日 2017-12-13 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (2.9 Å) 主引用文献 Capped RNA primer binding to influenza polymerase and implications for the mechanism of cap-binding inhibitors. Nucleic Acids Res., 46, 2018
6EUV	Structure of the midlink and cap-binding domains of influenza A polymerase PB2 subunit with a bound azaindole cap-binding inhibitor (VX-787) 分子名称: (2S,3S)-3-[[5-fluoranyl-2-(5-fluoranyl-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-4-yl]amino]bicyclo[2.2.2]octane-2-carboxylic acid, NICKEL (II) ION, Polymerase basic protein 2 著者 Cusack, S, Lethier, M. 登録日 2017-10-31 公開日 2017-12-13 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Capped RNA primer binding to influenza polymerase and implications for the mechanism of cap-binding inhibitors. Nucleic Acids Res., 46, 2018

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