4XG7
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![BU of 4xg7 by Molmil](/molmil-images/mine/4xg7) | Crystal structure of an inhibitor-bound Syk | 分子名称: | 1-[(3-methyl-1-{2-[(1-methyl-1H-indazol-5-yl)amino]pyrimidin-4-yl}-1H-pyrazol-4-yl)methyl]azetidin-3-ol, Tyrosine-protein kinase SYK | 著者 | Lee, S.J, Choi, J, Han, B.G, Song, H, Koh, J.S, Lee, B.I. | 登録日 | 2014-12-30 | 公開日 | 2015-12-30 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (1.76 Å) | 主引用文献 | Crystal structures of spleen tyrosine kinase in complex with novel inhibitors: structural insights for design of anticancer drugs Febs J., 283, 2016
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4XG6
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![BU of 4xg6 by Molmil](/molmil-images/mine/4xg6) | Crystal structure of an inhibitor-bound Syk | 分子名称: | 1-[(1-{2-[(3,5-dimethylphenyl)amino]pyrimidin-4-yl}-3-methyl-1H-pyrazol-4-yl)methyl]azetidin-3-ol, Tyrosine-protein kinase SYK | 著者 | Lee, S.J, Choi, J, Han, B.G, Song, H, Koh, J.S, Lee, B.I. | 登録日 | 2014-12-30 | 公開日 | 2015-12-30 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Crystal structures of spleen tyrosine kinase in complex with novel inhibitors: structural insights for design of anticancer drugs Febs J., 283, 2016
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4XG4
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![BU of 4xg4 by Molmil](/molmil-images/mine/4xg4) | Crystal structure of an inhibitor-bound Syk | 分子名称: | (3R)-1-{[1-(5-fluoro-2-{[4-(2-hydroxyethoxy)-3,5-dimethylphenyl]amino}pyrimidin-4-yl)-4-methyl-1H-pyrrol-3-yl]methyl}pyrrolidin-3-ol, Tyrosine-protein kinase SYK | 著者 | Lee, S.J, Choi, J, Han, B.G, Song, H, Koh, J.S, Lee, B.I. | 登録日 | 2014-12-30 | 公開日 | 2015-12-30 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Crystal structures of spleen tyrosine kinase in complex with novel inhibitors: structural insights for design of anticancer drugs Febs J., 283, 2016
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4XG9
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![BU of 4xg9 by Molmil](/molmil-images/mine/4xg9) | Crystal structure of an inhibitor-bound Syk | 分子名称: | 1-[(1-{2-[(3-chloro-1,2-dimethyl-1H-indol-5-yl)amino]pyrimidin-4-yl}-3-methyl-1H-pyrazol-4-yl)methyl]azetidin-3-ol, Tyrosine-protein kinase SYK | 著者 | Lee, S.J, Choi, J, Han, B.G, Song, H, Koh, J.S, Lee, B.I. | 登録日 | 2014-12-30 | 公開日 | 2015-12-30 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (2.91 Å) | 主引用文献 | Crystal structures of spleen tyrosine kinase in complex with novel inhibitors: structural insights for design of anticancer drugs Febs J., 283, 2016
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6WE2
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![BU of 6we2 by Molmil](/molmil-images/mine/6we2) | Human PARP14 (ARTD8), catalytic fragment in complex with RBN012759 | 分子名称: | 1,2-ETHANEDIOL, 7-(cyclopropylmethoxy)-5-fluoro-2-{[(trans-4-hydroxycyclohexyl)sulfanyl]methyl}quinazolin-4(3H)-one, Isoform 1 of Protein mono-ADP-ribosyltransferase PARP14 | 著者 | Swinger, K.K, Schenkel, L.B, Kuntz, K.W. | 登録日 | 2020-04-01 | 公開日 | 2021-03-24 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.66 Å) | 主引用文献 | A potent and selective PARP14 inhibitor decreases protumor macrophage gene expression and elicits inflammatory responses in tumor explants. Cell Chem Biol, 28, 2021
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4XG8
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![BU of 4xg8 by Molmil](/molmil-images/mine/4xg8) | Crystal structure of an inhibitor-bound Syk | 分子名称: | 1-[(1-{2-[(3-chloro-1-methyl-1H-indazol-5-yl)amino]pyrimidin-4-yl}-3-methyl-1H-pyrazol-4-yl)methyl]azetidin-3-ol, Tyrosine-protein kinase SYK | 著者 | Lee, S.J, Choi, J, Han, B.G, Song, H, Koh, J.S, Lee, B.I. | 登録日 | 2014-12-30 | 公開日 | 2015-12-30 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Crystal structures of spleen tyrosine kinase in complex with novel inhibitors: structural insights for design of anticancer drugs Febs J., 283, 2016
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4XG3
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![BU of 4xg3 by Molmil](/molmil-images/mine/4xg3) | Crystal structure of an inhibitor-bound Syk | 分子名称: | 4-{[5-fluoro-4-(3-{[(3R)-3-hydroxypyrrolidin-1-yl]methyl}-4-methyl-1H-pyrrol-1-yl)pyrimidin-2-yl]amino}-2,6-dimethylphenyl methanesulfonate, Tyrosine-protein kinase SYK | 著者 | Lee, S.J, Choi, J, Han, B.G, Song, H, Koh, J.S, Lee, B.I. | 登録日 | 2014-12-30 | 公開日 | 2015-12-30 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Crystal structures of spleen tyrosine kinase in complex with novel inhibitors: structural insights for design of anticancer drugs Febs J., 283, 2016
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6K1J
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![BU of 6k1j by Molmil](/molmil-images/mine/6k1j) | Human nucleosome core particle with H2A.X variant | 分子名称: | CHLORIDE ION, DNA (145-MER), Histone H2AX, ... | 著者 | Sharma, D, De Falco, L, Davey, C.A. | 登録日 | 2019-05-10 | 公開日 | 2020-01-15 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.85 Å) | 主引用文献 | PARP1 exhibits enhanced association and catalytic efficiency with gamma H2A.X-nucleosome. Nat Commun, 10, 2019
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5LU6
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![BU of 5lu6 by Molmil](/molmil-images/mine/5lu6) | Heptose isomerase mutant - H64Q | 分子名称: | 1,2-ETHANEDIOL, D-ALTRO-HEPT-2-ULOSE 7-PHOSPHATE, GLYCEROL, ... | 著者 | Vivoli, M, Harmer, N.J, Pang, J. | 登録日 | 2016-09-08 | 公開日 | 2017-12-06 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (1.67 Å) | 主引用文献 | A half-site multimeric enzyme achieves its cooperativity without conformational changes. Sci Rep, 7, 2017
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6K1I
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![BU of 6k1i by Molmil](/molmil-images/mine/6k1i) | Human nucleosome core particle with gammaH2A.X variant | 分子名称: | CHLORIDE ION, DNA (147-MER), Histone H2AX, ... | 著者 | Sharma, D, De Falco, L, Davey, C.A. | 登録日 | 2019-05-10 | 公開日 | 2020-01-15 | 最終更新日 | 2024-03-27 | 実験手法 | X-RAY DIFFRACTION (2.75 Å) | 主引用文献 | PARP1 exhibits enhanced association and catalytic efficiency with gamma H2A.X-nucleosome. Nat Commun, 10, 2019
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6K1K
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![BU of 6k1k by Molmil](/molmil-images/mine/6k1k) | Human nucleosome core particle with H2A.X S139E variant | 分子名称: | CHLORIDE ION, DNA (145-MER), Histone H2AX, ... | 著者 | Sharma, D, De Falco, L, Davey, C.A. | 登録日 | 2019-05-10 | 公開日 | 2020-01-15 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | PARP1 exhibits enhanced association and catalytic efficiency with gamma H2A.X-nucleosome. Nat Commun, 10, 2019
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4XG2
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![BU of 4xg2 by Molmil](/molmil-images/mine/4xg2) | Crystal structure of ligand-free Syk | 分子名称: | Tyrosine-protein kinase SYK | 著者 | Lee, S.J, Choi, J, Han, B.G, Song, H, Koh, J.S, Lee, B.I. | 登録日 | 2014-12-30 | 公開日 | 2015-12-30 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (2.21 Å) | 主引用文献 | Crystal structures of spleen tyrosine kinase in complex with novel inhibitors: structural insights for design of anticancer drugs Febs J., 283, 2016
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5A3N
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![BU of 5a3n by Molmil](/molmil-images/mine/5a3n) | Crystal structure of human PLU-1 (JARID1B) in complex with KDOAM25a | 分子名称: | 1,2-ETHANEDIOL, 2-[[[2-[2-(dimethylamino)ethyl-ethyl-amino]-2-oxidanylidene-ethyl]amino]methyl]pyridine-4-carboxamide, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ... | 著者 | Srikannathasan, V, Johansson, C, Gileadi, C, Nuzzi, A, Ruda, G.F, Kopec, J, von Delft, F, Arrowsmith, C.H, Bountra, C, Edwards, A, Brennan, P, Oppermann, U. | 登録日 | 2015-06-02 | 公開日 | 2015-07-08 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Potent and Selective KDM5 Inhibitor Stops Cellular Demethylation of H3K4me3 at Transcription Start Sites and Proliferation of MM1S Myeloma Cells. Cell Chem Biol, 24, 2017
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5B1S
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![BU of 5b1s by Molmil](/molmil-images/mine/5b1s) | Crystal structure of Trypanosoma cruzi spermidine synthase in complex with 2-(2-fluorophenyl)ethanamine | 分子名称: | 2-(2-fluorophenyl)ethanamine, 5'-[(S)-(3-AMINOPROPYL)(METHYL)-LAMBDA~4~-SULFANYL]-5'-DEOXYADENOSINE, Spermidine synthase, ... | 著者 | Amano, Y, Tateishi, Y. | 登録日 | 2015-12-17 | 公開日 | 2016-12-21 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (1.58 Å) | 主引用文献 | In silico, in vitro, X-ray crystallography, and integrated strategies for discovering spermidine synthase inhibitors for Chagas disease Sci Rep, 7, 2017
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4V1S
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![BU of 4v1s by Molmil](/molmil-images/mine/4v1s) | Structure of the GH76 alpha-mannanase BT2949 from Bacteroides thetaiotaomicron | 分子名称: | ALPHA-1,6-MANNANASE, GLYCEROL | 著者 | Thompson, A.J, Cuskin, F, Spears, R.J, Dabin, J, Turkenburg, J.P, Gilbert, H.J, Davies, G.J. | 登録日 | 2014-10-02 | 公開日 | 2015-02-11 | 最終更新日 | 2024-05-01 | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | 主引用文献 | Structure of the Gh76 Alpha-Mannanase Homolog, Bt2949, from the Gut Symbiont Bacteroides Thetaiotaomicron Acta Crystallogr.,Sect.D, 71, 2015
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4WAJ
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![BU of 4waj by Molmil](/molmil-images/mine/4waj) | |
8PEI
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![BU of 8pei by Molmil](/molmil-images/mine/8pei) | Crystal structure of the biphotochromic fluorescent protein SAASoti (C21N/V127T variant) in its green on-state | 分子名称: | C21N/V127T form of the biphotochromic fluorescent protein SAASoti | 著者 | Boyko, K.M, Varfolomeeva, L.A, Matyuta, I.O, Gavshina, A.V, Solovyev, I.D, Popov, V.O, Savitsky, A.P. | 登録日 | 2023-06-14 | 公開日 | 2024-01-17 | 最終更新日 | 2024-07-31 | 実験手法 | X-RAY DIFFRACTION (3 Å) | 主引用文献 | The role of the correlated motion(s) of the chromophore in photoswitching of green and red forms of the photoconvertible fluorescent protein mSAASoti. Sci Rep, 14, 2024
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7OIN
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![BU of 7oin by Molmil](/molmil-images/mine/7oin) | Crystal structure of LSSmScarlet - a genetically encoded red fluorescent protein with a large Stokes shift | 分子名称: | LSSmScarlet - Genetically Encoded Red Fluorescent Proteins with a Large Stokes Shift, SODIUM ION, SULFATE ION | 著者 | Boyko, K.M, Nikolaeva, A.Y, Dorovatovskii, P.V, Subach, O.M, Vlaskina, A.V, Agapova, Y.K, Ivashkina, O.I, Popov, V.O, Subach, F.V. | 登録日 | 2021-05-12 | 公開日 | 2022-02-16 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (1.4 Å) | 主引用文献 | LSSmScarlet, dCyRFP2s, dCyOFP2s and CRISPRed2s, Genetically Encoded Red Fluorescent Proteins with a Large Stokes Shift. Int J Mol Sci, 22, 2021
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6D43
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![BU of 6d43 by Molmil](/molmil-images/mine/6d43) | |
6UDC
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![BU of 6udc by Molmil](/molmil-images/mine/6udc) | Spectroscopic and structural characterization of a genetically encoded direct sensor for protein-ligand interactions | 分子名称: | BIOTIN, Streptavidin | 著者 | Mills, J.H, Gleason, P.R, Simmons, C.R, Henderson, J.N, Kartchner, B.K. | 登録日 | 2019-09-19 | 公開日 | 2020-09-23 | 最終更新日 | 2021-10-13 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Structural Origins of Altered Spectroscopic Properties upon Ligand Binding in Proteins Containing a Fluorescent Noncanonical Amino Acid. Biochemistry, 60, 2021
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1EB2
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![BU of 1eb2 by Molmil](/molmil-images/mine/1eb2) | Trypsin inhibitor complex (BPO) | 分子名称: | 3-[(Z)-AMINO(IMINO)METHYL]-N-[2-(4-BENZOYL-1-PIPERIDINYL)-2-OXO-1-PHENYLETHYL]BENZAMIDE, CALCIUM ION, SULFATE ION, ... | 著者 | Wilkinson, K.W, Young, S.C, Liebeschuetz, J.W, Brady, R.L. | 登録日 | 2001-07-18 | 公開日 | 2002-02-11 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Pro_Select: Combining Structure-Based Drug Design and Array-Based Chemistry for Rapid Lead Discovery. 2. The Development of a Series of Highly Potent and Selective Factor Xa Inhibitors J.Med.Chem., 45, 2002
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6UC3
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![BU of 6uc3 by Molmil](/molmil-images/mine/6uc3) | Spectroscopic and structural characterization of a genetically encoded direct sensor for protein-ligand interactions | 分子名称: | BIOTIN, Streptavidin | 著者 | Mills, J.H, Gleason, P.R, Simmons, C.R, Henderson, J.N, Kartchner, B.K. | 登録日 | 2019-09-13 | 公開日 | 2020-09-16 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (1.84 Å) | 主引用文献 | Structural Origins of Altered Spectroscopic Properties upon Ligand Binding in Proteins Containing a Fluorescent Noncanonical Amino Acid. Biochemistry, 60, 2021
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6UD1
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![BU of 6ud1 by Molmil](/molmil-images/mine/6ud1) | Spectroscopic and structural characterization of a genetically encoded direct sensor for protein-ligand interactions | 分子名称: | CHLORIDE ION, Streptavidin | 著者 | Mills, J.H, Gleason, P.R, Simmons, C.R, Henderson, J.N, Kartchner, B.K. | 登録日 | 2019-09-18 | 公開日 | 2021-02-10 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (1.55 Å) | 主引用文献 | Structural Origins of Altered Spectroscopic Properties upon Ligand Binding in Proteins Containing a Fluorescent Noncanonical Amino Acid. Biochemistry, 60, 2021
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7RHO
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![BU of 7rho by Molmil](/molmil-images/mine/7rho) | |
6ZGL
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![BU of 6zgl by Molmil](/molmil-images/mine/6zgl) | |