5B1S
Crystal structure of Trypanosoma cruzi spermidine synthase in complex with 2-(2-fluorophenyl)ethanamine
Summary for 5B1S
Entry DOI | 10.2210/pdb5b1s/pdb |
Descriptor | Spermidine synthase, putative, 5'-[(S)-(3-AMINOPROPYL)(METHYL)-LAMBDA~4~-SULFANYL]-5'-DEOXYADENOSINE, 2-(2-fluorophenyl)ethanamine, ... (4 entities in total) |
Functional Keywords | polyamine synthesis, transferase |
Biological source | Trypanosoma cruzi strain CL Brener |
Total number of polymer chains | 4 |
Total formula weight | 138397.35 |
Authors | Amano, Y.,Tateishi, Y. (deposition date: 2015-12-17, release date: 2016-12-21, Last modification date: 2023-11-08) |
Primary citation | Yoshino, R.,Yasuo, N.,Hagiwara, Y.,Ishida, T.,Inaoka, D.K.,Amano, Y.,Tateishi, Y.,Ohno, K.,Namatame, I.,Niimi, T.,Orita, M.,Kita, K.,Akiyama, Y.,Sekijima, M. In silico, in vitro, X-ray crystallography, and integrated strategies for discovering spermidine synthase inhibitors for Chagas disease Sci Rep, 7:6666-6666, 2017 Cited by PubMed: 28751689DOI: 10.1038/s41598-017-06411-9 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.58 Å) |
Structure validation
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