PDB: 1500 件ウェブページステータス検索Chemie searchBIRD

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5EMM	Crystal structure of PRMT5:MEP50 with Compound 15 and sinefungin 分子名称: GLYCEROL, Methylosome protein 50, Protein arginine N-methyltransferase 5, ... 著者 Boriack-Sjodin, P.A, Jin, L. 登録日 2015-11-06 公開日 2016-02-24 最終更新日 2018-04-18 実験手法 X-RAY DIFFRACTION (2.37 Å) 主引用文献 Structure and Property Guided Design in the Identification of PRMT5 Tool Compound EPZ015666. ACS Med Chem Lett, 7, 2016
8CSG	Human PRMT5:MEP50 structure with Fragment 1 and MTA Bound 分子名称: 1,2-ETHANEDIOL, 5'-DEOXY-5'-METHYLTHIOADENOSINE, 6-bromo-1H-pyrrolo[3,2-b]pyridin-5-amine, ... 著者 Gunn, R.J, Lawson, J.D, Smith, C.R. 登録日 2022-05-12 公開日 2022-10-05 最終更新日 2024-05-22 実験手法 X-RAY DIFFRACTION (2.48 Å) 主引用文献 Fragment optimization and elaboration strategies - the discovery of two lead series of PRMT5/MTA inhibitors from five fragment hits. Rsc Med Chem, 13, 2022
1NZ1	Solution structure of the S. cerevisiae U6 Intramolecular stem-loop containing an SP phosphorothioate at nucleotide U80 分子名称: SP U6 Intramolecular Stem-Loop RNA 著者 Reiter, N.J, Nikstad, L.J, Allman, A.M, Johnson, R.J, Butcher, S.E. 登録日 2003-02-14 公開日 2003-05-13 最終更新日 2024-05-22 実験手法 SOLUTION NMR 主引用文献 Structure of the U6 RNA intramolecular stem-loop harboring an S(P)-phosphorothioate modification. RNA, 9, 2003
4WAN	Crystal structure of Msl5 protein in complex with RNA at 1.8 A 分子名称: ACETATE ION, Branchpoint-bridging protein, GLYCEROL, ... 著者 Jacewicz, A, Smith, P, Chico, L, Schwer, B, Shuman, S. 登録日 2014-08-29 公開日 2014-12-17 最終更新日 2023-12-27 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Structural basis for recognition of intron branchpoint RNA by yeast Msl5 and selective effects of interfacial mutations on splicing of yeast pre-mRNAs. Rna, 21, 2015
4WAL	Crystal structure of selenomethionine Msl5 protein in complex with RNA at 2.2 A 分子名称: Branchpoint-bridging protein, CHLORIDE ION, GLYCEROL, ... 著者 Jacewicz, A, Smith, P, Chico, L, Schwer, B, Shuman, S. 登録日 2014-08-29 公開日 2014-12-17 最終更新日 2023-12-27 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Structural basis for recognition of intron branchpoint RNA by yeast Msl5 and selective effects of interfacial mutations on splicing of yeast pre-mRNAs. Rna, 21, 2015
4A6Q	Crystal structure of mouse SAP18 residues 6-143 分子名称: (4S)-2-METHYL-2,4-PENTANEDIOL, HISTONE DEACETYLASE COMPLEX SUBUNIT SAP18, ISOPROPYL ALCOHOL 著者 Murachelli, A.G, Ebert, J, Basquin, C, Le Hir, H, Conti, E. 登録日 2011-11-08 公開日 2012-03-07 最終更新日 2015-03-18 実験手法 X-RAY DIFFRACTION (1.5 Å) 主引用文献 The Structure of the Asap Core Complex Reveals the Existence of a Pinin-Containing Psap Complex Nat.Struct.Mol.Biol., 19, 2012
4A90	Crystal structure of mouse SAP18 residues 1-143 分子名称: GLYCEROL, HISTONE DEACETYLASE COMPLEX SUBUNIT SAP18 著者 Murachelli, A.G, Ebert, J, Basquin, C, Le Hir, H, Conti, E. 登録日 2011-11-22 公開日 2012-03-07 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 The Structure of the Asap Core Complex Reveals the Existence of a Pinin-Containing Psap Complex Nat.Struct.Mol.Biol., 19, 2012
7D1A	cryo-EM structure of a group II intron RNP complexed with its reverse transcriptase 分子名称: Group II intron-encoded protein LtrA, RNA (5'-R(P*CP*AP*CP*AP*UP*CP*CP*AP*UP*AP*AP*C)-3'), RNA (692-MER) 著者 Liu, N, Dong, X.L, Hu, C.X, Zeng, J.W, Wang, J.W, Wang, J, Wang, H.W, Belfort, M. 登録日 2020-09-14 公開日 2020-10-21 最終更新日 2024-03-27 実験手法 ELECTRON MICROSCOPY (3.8 Å) 主引用文献 Exon and protein positioning in a pre-catalytic group II intron RNP primed for splicing. Nucleic Acids Res., 48, 2020
8FLI	Cryo-EM structure of a group II intron immediately before branching 分子名称: Group II Intron, MAGNESIUM ION, Maturase reverse transcriptase 著者 Haack, D.B, Rudolfs, B.G, Zhang, C, Lyumkis, D, Toor, N. 登録日 2022-12-21 公開日 2023-12-13 最終更新日 2024-02-07 実験手法 ELECTRON MICROSCOPY (3.8 Å) 主引用文献 Structural basis of branching during RNA splicing. Nat.Struct.Mol.Biol., 31, 2024
1H64	CRYSTAL STRUCTURE OF THE SM-RELATED PROTEIN OF P. ABYSSI: THE BIOLOGICAL UNIT IS A HEPTAMER 分子名称: SNRNP SM-LIKE PROTEIN 著者 Mayer, C, Weeks, S, Suck, D. 登録日 2001-06-05 公開日 2002-12-19 最終更新日 2024-05-01 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Crystal Structures of the Pyrococcus Abyssi Sm Core and its Complex with RNA.Common Features of RNA Binding in Archaea and Eukarya J.Biol.Chem., 278, 2003
1G5V	SOLUTION STRUCTURE OF THE TUDOR DOMAIN OF THE HUMAN SMN PROTEIN 分子名称: SURVIVAL MOTOR NEURON PROTEIN 1 著者 Selenko, P, Sprangers, R, Stier, G, Buehler, D, Fischer, U, Sattler, M. 登録日 2000-11-02 公開日 2001-05-02 最終更新日 2024-05-01 実験手法 SOLUTION NMR 主引用文献 SMN tudor domain structure and its interaction with the Sm proteins. Nat.Struct.Biol., 8, 2001
3NVI	Structure of N-terminal truncated Nop56/58 bound with L7Ae and box C/D RNA 分子名称: 50S ribosomal protein L7Ae, NOP5/NOP56 related protein, RNA (5'-R(*CP*UP*CP*UP*GP*AP*CP*CP*GP*AP*AP*AP*GP*GP*CP*GP*UP*GP*AP*UP*GP*AP*GP*C)-3') 著者 Li, H, Xue, S, Wang, R. 登録日 2010-07-08 公開日 2011-07-20 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (2.709 Å) 主引用文献 Structural basis for substrate placement by an archaeal box C/D ribonucleoprotein particle. Mol.Cell, 39, 2010
3NMU	Crystal Structure of substrate-bound halfmer box C/D RNP 分子名称: 50S ribosomal protein L7Ae, Fibrillarin-like rRNA/tRNA 2'-O-methyltransferase, NOP5/NOP56 related protein, ... 著者 Li, H, Xue, S, Wang, R. 登録日 2010-06-22 公開日 2011-05-25 最終更新日 2023-12-27 実験手法 X-RAY DIFFRACTION (2.729 Å) 主引用文献 Structural basis for substrate placement by an archaeal box C/D ribonucleoprotein particle. Mol.Cell, 39, 2010
1LC6	Solution Structure of the U6 Intramolecular Stem-loop RNA 分子名称: U6 Intramolecular Stem-loop RNA 著者 Huppler, A, Nikstad, L.J, Allmann, A.M, Brow, D.A, Butcher, S.E. 登録日 2002-04-05 公開日 2002-05-29 最終更新日 2024-05-22 実験手法 SOLUTION NMR 主引用文献 Metal binding and base ionization in the U6 RNA intramolecular stem-loop structure. Nat.Struct.Biol., 9, 2002
1U2A	STEM LOOP IIA FROM U2SNRNA OF SACCHAROMYCES CEREVISIAE, NMR, MINIMIZED AVERAGE STRUCTURE 分子名称: RNA (5'-R(P*GP*GP*UP*CP*AP*GP*UP*GP*UP*AP*AP*CP*AP*AP*CP*UP*GP*AP*CP*C)-3') 著者 Stallings, S.C, Moore, P.B. 登録日 1997-08-19 公開日 1998-03-04 最終更新日 2024-05-22 実験手法 SOLUTION NMR 主引用文献 The structure of an essential splicing element: stem loop IIa from yeast U2 snRNA. Structure, 5, 1997
1XHP	Solution Structure of the Extended U6 ISL as Observed in the U2/U6 complex from Saccharomyces cerevisiae 分子名称: U6 snRNA 著者 Sashital, D.G, Cornilescu, G, Butcher, S.E. 登録日 2004-09-20 公開日 2004-11-23 最終更新日 2024-05-29 実験手法 SOLUTION NMR 主引用文献 U2-U6 RNA folding reveals a group II intron-like domain and a four-helix junction Nat.Struct.Mol.Biol., 11, 2004
1SYZ	Solution structure of the S. Cerevisiae U6 intramolecular stem loop (ISL) RNA at pH 5.7 分子名称: U6 INTRAMOLECULAR STEM-LOOP RNA 著者 Reiter, N.J, Blad, H, Abildgaard, F, Butcher, S.E. 登録日 2004-04-02 公開日 2004-11-09 最終更新日 2024-05-22 実験手法 SOLUTION NMR 主引用文献 Dynamics in the U6 RNA Intramolecular Stem-Loop: A Base Flipping Conformational Change. Biochemistry, 43, 2004
2WAC	Extended Tudor domain of Drosophila Melanogaster Tudor-SN (p100) 分子名称: CG7008-PA 著者 Friberg, A, Corsini, L, Sattler, M. 登録日 2009-02-04 公開日 2009-03-03 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Structure and Ligand Binding of the Extended Tudor Domain of D. Melanogaster Tudor-Sn J.Mol.Biol., 387, 2009
1OIA	U1A rnp domain 1-95 分子名称: U1 SMALL NUCLEAR RIBONUCLEOPROTEIN A 著者 Nagai, K, Evans, P.R. 登録日 2003-06-12 公開日 2003-06-26 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Crystal Structure of the RNA-Binding Domain of the U1 Small Nuclear Ribonucleoprotein A Nature, 348, 1990
2U2A	STEM LOOP IIA FROM U2 SNRNA OF SACCHAROMYCES CEREVISIAE, NMR, MINIMIZED AVERAGE STRUCTURE 分子名称: RNA (5'-R(P*GP*GP*UP*CP*AP*GP*UP*GP*UP*AP*AP*CP*AP*AP*CP*UP*GP*AP*CP*C)-3') 著者 Stallings, S.C, Moore, P.B. 登録日 1997-08-20 公開日 1998-03-04 最終更新日 2024-05-22 実験手法 SOLUTION NMR 主引用文献 The structure of an essential splicing element: stem loop IIa from yeast U2 snRNA. Structure, 5, 1997
8OLY	Structure of Oceanobacillus iheyensis group II intron post first step of splicing in the presence of K+, Mg2+ and intronistat B 分子名称: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, 5'-exon, Group IIC intron, ... 著者 Silvestri, I, Marcia, M. 登録日 2023-03-30 公開日 2024-06-19 最終更新日 2024-07-03 実験手法 X-RAY DIFFRACTION (3.11 Å) 主引用文献 Targeting the conserved active site of splicing machines with specific and selective small molecule modulators. Nat Commun, 15, 2024
8OM0	Structure of Oceanobacillus iheyensis group II intron in the presence of Na+, Mg2+ and intronistat B 分子名称: 3,4,5-trihydroxybenzoic acid, Domains 1-5, MAGNESIUM ION, ... 著者 Silvestri, I, Marcia, M. 登録日 2023-03-31 公開日 2024-06-19 最終更新日 2024-07-03 実験手法 X-RAY DIFFRACTION (3.61 Å) 主引用文献 Targeting the conserved active site of splicing machines with specific and selective small molecule modulators. Nat Commun, 15, 2024
8OLZ	Structure of Oceanobacillus iheyensis group II intron in the presence of K+, Mg2+, 5'-exon, and intronistat B after 2h30 soaking 分子名称: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, 5'-exon, DOMAINS 1-5, ... 著者 Silvestri, I, Marcia, M. 登録日 2023-03-30 公開日 2024-06-19 最終更新日 2024-07-03 実験手法 X-RAY DIFFRACTION (3.31 Å) 主引用文献 Targeting the conserved active site of splicing machines with specific and selective small molecule modulators. Nat Commun, 15, 2024
8OLV	Structure of Oceanobacillus iheyensis group II intron in the presence of K+, Mg2+ and ARN25850 分子名称: 2-[2,6-bis(bromanyl)-3,4,5-tris(oxidanyl)phenyl]carbonyl-~{N}-(2-pyrrolidin-1-ylethyl)-1-benzofuran-5-carboxamide, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, Group IIC intron, ... 著者 Silvestri, I, Marcia, M. 登録日 2023-03-30 公開日 2024-06-19 最終更新日 2024-07-03 実験手法 X-RAY DIFFRACTION (2.81 Å) 主引用文献 Targeting the conserved active site of splicing machines with specific and selective small molecule modulators. Nat Commun, 15, 2024
8OLW	Structure of Oceanobacillus iheyensis group II intron before the first step of splicing in the presence of K+, Ca2+ and intronistat B 分子名称: CALCIUM ION, Group IIC intron, POTASSIUM ION 著者 Silvestri, I, Marcia, M. 登録日 2023-03-30 公開日 2024-06-19 最終更新日 2024-07-03 実験手法 X-RAY DIFFRACTION (4 Å) 主引用文献 Targeting the conserved active site of splicing machines with specific and selective small molecule modulators. Nat Commun, 15, 2024

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