PDB: 71589 件ウェブページステータス検索Chemie searchBIRD

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7CWB	Ambient-Temperature Serial Femtosecond X-ray Crystal structure of SARS-CoV-2 Main Protease at 1.9 A Resolution (C121) 分子名称: 3C-like proteinase 著者 DeMirci, H. 登録日 2020-08-27 公開日 2020-09-30 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Near-physiological-temperature serial crystallography reveals conformations of SARS-CoV-2 main protease active site for improved drug repurposing. Structure, 29, 2021
7CWC	Ambient-Temperature Serial Femtosecond X-ray Crystal structure of SARS-CoV-2 Main Protease at 2.1 A Resolution (P212121) 分子名称: 3C-like proteinase 著者 DeMirci, H. 登録日 2020-08-27 公開日 2020-09-30 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Near-physiological-temperature serial crystallography reveals conformations of SARS-CoV-2 main protease active site for improved drug repurposing. Structure, 29, 2021
6C3G	AMYLOID FORMING PEPTIDE KALGIS FROM TRANSTHYRETIN 分子名称: GLYCEROL, LYS-ALA-LEU-GLY-ILE-SER, SULFATE ION 著者 Saelices, L, Sawaya, M.R, Eisenberg, D.S. 登録日 2018-01-09 公開日 2018-04-18 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (1.601 Å) 主引用文献 Crystal structures of amyloidogenic segments of human transthyretin. Protein Sci., 27, 2018
1RHG	THE STRUCTURE OF GRANULOCYTE-COLONY-STIMULATING FACTOR AND ITS RELATIONSHIP TO THOSE OF OTHER GROWTH FACTORS 分子名称: GRANULOCYTE COLONY-STIMULATING FACTOR 著者 Hill, C.P, Osslund, T.D, Eisenberg, D. 登録日 1993-01-29 公開日 1994-01-31 最終更新日 2024-06-05 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 The structure of granulocyte-colony-stimulating factor and its relationship to other growth factors. Proc.Natl.Acad.Sci.USA, 90, 1993
7UNL	Human TMEM175 in an open state 分子名称: Endosomal/lysosomal potassium channel TMEM175, POTASSIUM ION 著者 Oh, S, Hite, R.K. 登録日 2022-04-11 公開日 2022-06-01 最終更新日 2024-02-14 実験手法 ELECTRON MICROSCOPY (2.45 Å) 主引用文献 Differential ion dehydration energetics explains selectivity in the non-canonical lysosomal K + channel TMEM175. Elife, 11, 2022
7TZJ	SARS CoV-2 PLpro in complex with inhibitor 3k 分子名称: DIMETHYL SULFOXIDE, N-[(3-fluorophenyl)methyl]-1-[(1R)-1-naphthalen-1-ylethyl]piperidine-4-carboxamide, Papain-like protease, ... 著者 Calleja, D.J, Klemm, T, Lechtenberg, B.C, Kuchel, N.W, Lessene, G, Komander, D. 登録日 2022-02-15 公開日 2022-03-02 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.66 Å) 主引用文献 Insights Into Drug Repurposing, as Well as Specificity and Compound Properties of Piperidine-Based SARS-CoV-2 PLpro Inhibitors. Front Chem, 10, 2022
6RT0	cryo-em structure of alpha-synuclein fibril polymorph 2A 分子名称: Alpha-synuclein 著者 Guerrero-Ferreira, R, Taylor, N.M.I, Arteni, A.A, Melki, R, Meier, B.H, Bockmann, A, Bousset, L, Stahlberg, H. 登録日 2019-05-22 公開日 2019-06-26 最終更新日 2024-05-22 実験手法 ELECTRON MICROSCOPY (3.1 Å) 主引用文献 Two new polymorphic structures of human full-length alpha-synuclein fibrils solved by cryo-electron microscopy. Elife, 8, 2019
7TVH	Hyperlytic variant of Tae1, Type VI secretion amidase effector 1, from Pseudomonas aeruginosa (Cys110Ser) 分子名称: Peptidoglycan amidase Tse1 著者 Radkov, A, Saunders, H, Chou, S. 登録日 2022-02-04 公開日 2022-07-06 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (1.71 Å) 主引用文献 Antibacterial potency of type VI amidase effector toxins is dependent on substrate topology and cellular context. Elife, 11, 2022
6DHY	Crystallogrpahic tetramer of Zn-bound RIDC1 variant bearing two disulfide bonded cysteines 分子名称: CALCIUM ION, HEME C, Soluble cytochrome b562, ... 著者 Tezcan, F.A, Churchfield, L.A. 登録日 2018-05-21 公開日 2018-07-25 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.22 Å) 主引用文献 Determining the Structural and Energetic Basis of Allostery in a De Novo Designed Metalloprotein Assembly. J. Am. Chem. Soc., 140, 2018
7AB7	Structure of Chloroflexus aggregans flavin based fluorescent protein (CagFbFP) I52T Q148K variant 分子名称: FLAVIN MONONUCLEOTIDE, GLYCEROL, Multi-sensor hybrid histidine kinase, ... 著者 Remeeva, A, Nazarenko, V, Kovalev, K, Gushchin, I. 登録日 2020-09-06 公開日 2021-04-21 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 The molecular basis of spectral tuning in blue- and red-shifted flavin-binding fluorescent proteins. J.Biol.Chem., 296, 2021
7AB6	Structure of Chloroflexus aggregans flavin based fluorescent protein (CagFbFP) I52T variant 分子名称: FLAVIN MONONUCLEOTIDE, GLYCEROL, Multi-sensor hybrid histidine kinase, ... 著者 Remeeva, A, Nazarenko, V, Kovalev, K, Gushchin, I. 登録日 2020-09-06 公開日 2021-04-21 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 The molecular basis of spectral tuning in blue- and red-shifted flavin-binding fluorescent proteins. J.Biol.Chem., 296, 2021
7ABY	Crystal structure of iLOV-Q489K mutant 分子名称: ACETATE ION, FLAVIN MONONUCLEOTIDE, Phototropin-2 著者 Granzin, J, Batra-Safferling, R. 登録日 2020-09-09 公開日 2021-04-21 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (1.45 Å) 主引用文献 The molecular basis of spectral tuning in blue- and red-shifted flavin-binding fluorescent proteins. J.Biol.Chem., 296, 2021
6DHZ	Crystallographic octamer of a metal-free RIDC1 variant bearing two disulfide bonded cysteines 分子名称: CALCIUM ION, HEME C, Soluble cytochrome b562 著者 Tezcan, F.A, Churchfield, L.A. 登録日 2018-05-21 公開日 2018-07-25 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Determining the Structural and Energetic Basis of Allostery in a De Novo Designed Metalloprotein Assembly. J. Am. Chem. Soc., 140, 2018
3N07	Structure of putative 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase from Vibrio cholerae 分子名称: 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase, MAGNESIUM ION 著者 Liu, W, Ramagopal, U.A, Toro, R, Burley, S.K, Almo, S.C, New York SGX Research Center for Structural Genomics (NYSGXRC) 登録日 2010-05-13 公開日 2010-08-04 最終更新日 2021-02-10 実験手法 X-RAY DIFFRACTION (1.76 Å) 主引用文献 Structural basis for the divergence of substrate specificity and biological function within HAD phosphatases in lipopolysaccharide and sialic acid biosynthesis. Biochemistry, 52, 2013
1TJ7	Structure determination and refinement at 2.44 A resolution of Argininosuccinate lyase from E. coli 分子名称: Argininosuccinate lyase, GLYCEROL, PHOSPHATE ION 著者 Bhaumik, P, Koski, M.K, Bergman, U, Wierenga, R.K. 登録日 2004-06-03 公開日 2004-10-26 最終更新日 2023-08-23 実験手法 X-RAY DIFFRACTION (2.44 Å) 主引用文献 Structure determination and refinement at 2.44 A resolution of argininosuccinate lyase from Escherichia coli. Acta Crystallogr.,Sect.D, 60, 2004
1TJL	Crystal structure of transcription factor DksA from E. coli 分子名称: DnaK suppressor protein, ZINC ION 著者 Perederina, A, Svetlov, V, Vassylyeva, M.N, Artsimovitch, I, Yokoyama, S, Vassylyev, D.G, RIKEN Structural Genomics/Proteomics Initiative (RSGI) 登録日 2004-06-06 公開日 2004-09-07 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Regulation through the secondary channel--structural framework for ppGpp-DksA synergism during transcription Cell(Cambridge,Mass.), 118, 2004
1VND	VND/NK-2 PROTEIN (HOMEODOMAIN), NMR 分子名称: VND/NK-2 PROTEIN 著者 Tsao, D.H.H, Gruschus, J.M, Wang, L.-H, Nirenberg, M, Ferretti, J.A. 登録日 1996-05-22 公開日 1996-11-08 最終更新日 2024-05-22 実験手法 SOLUTION NMR 主引用文献 The three-dimensional solution structure of the NK-2 homeodomain from Drosophila. J.Mol.Biol., 251, 1995
7A9B	Crystal structure of Shank1 PDZ domain with ARAP3-derived peptide 分子名称: 1,2-ETHANEDIOL, SH3 and multiple ankyrin repeat domains protein 1,Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 著者 Mariam McAuley, M, Ali, M, Ivarsson, Y, Knapp, S, Joerger, A.C, Structural Genomics Consortium (SGC) 登録日 2020-09-01 公開日 2020-10-21 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Crystal structure of Shank1 PDZ domain with ARAP3-derived peptide to be published
6AK2	Crystal structure of the syntenin PDZ1 domain in complex with the peptide inhibitor KSL-128018 分子名称: Syntenin-1, peptide inhibitor KSL-128018 著者 Jin, Z.Y, Park, J.H, Yun, J.H, Haugaard-Kedstrom, L.M, Lee, W.T. 登録日 2018-08-29 公開日 2019-09-04 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (1.868 Å) 主引用文献 A High-Affinity Peptide Ligand Targeting Syntenin Inhibits Glioblastoma. J.Med.Chem., 64, 2021
6I6E	Circular permutant of ribosomal protein S6, swap strand 1 , L10A mutant 分子名称: 30S ribosomal protein S6 著者 Wang, H, Logan, D.T, Oliveberg, M. 登録日 2018-11-15 公開日 2019-11-27 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.2 Å) 主引用文献 Exposing the distinctive modular behavior of beta-strands and alpha-helices in folded proteins. Proc.Natl.Acad.Sci.USA, 117, 2020
6EJT	Nuclease NucB from Bacillus licheniformis in P21 space group 分子名称: Nuclease, SULFATE ION 著者 Stransky, J, Dohnalek, J, Oestergaard, L.A. 登録日 2017-09-23 公開日 2019-04-10 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Structure of novel nuclease NucB from Bacillus licheniformis To Be Published
6AMI	Engineered tryptophan synthase b-subunit from Pyrococcus furiosus, PfTrpB4D11 with Trp non-covalently bound 分子名称: SODIUM ION, TRYPTOPHAN, Tryptophan synthase beta chain 1 著者 Buller, A.R. 登録日 2017-08-09 公開日 2018-05-16 最終更新日 2022-03-23 実験手法 X-RAY DIFFRACTION (1.97 Å) 主引用文献 Directed Evolution Mimics Allosteric Activation by Stepwise Tuning of the Conformational Ensemble. J. Am. Chem. Soc., 140, 2018
6I69	Circular permutant of ribosomal protein S6, adding 5aa to C terminal of P97-3, L10A mutant 分子名称: 30S ribosomal protein S6 著者 Wang, H, Logan, D.T, Oliveberg, M. 登録日 2018-11-15 公開日 2019-11-27 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.2 Å) 主引用文献 Exposing the distinctive modular behavior of beta-strands and alpha-helices in folded proteins. Proc.Natl.Acad.Sci.USA, 117, 2020
8Q5K	PqsR coinducer binding domain of Pseudomonas aeruginosa with ligand 2t : 2-(4-(3-((6-chloro-1-(2-methoxyethyl)-1H-benzo[d]imidazol-2-yl)amino)-2-hydroxypropoxy)phenyl)acetonitrile 分子名称: 1,2-ETHANEDIOL, 2-[4-[(2~{S})-3-[[6-chloranyl-1-(2-methoxyethyl)benzimidazol-2-yl]amino]-2-oxidanyl-propoxy]phenyl]ethanenitrile, Multiple virulence factor regulator MvfR 著者 Markham-Lee, Z.J, Emsley, J. 登録日 2023-08-09 公開日 2024-01-17 最終更新日 2024-04-17 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Design, Synthesis, and Evaluation of New 1 H -Benzo[ d ]imidazole Based PqsR Inhibitors as Adjuvant Therapy for Pseudomonas aeruginosa Infections. J.Med.Chem., 67, 2024
8FQ7	Nanobody with WIW inserted in CDR3 loop to Inhibit Growth of Alzheimer's Tau fibrils 分子名称: GLYCEROL, Nanobody with WIW insert in CDR3 loop to target tau fibrils 著者 Abskharon, R, Sawaya, M.R, Cascio, D.C, Eisenberg, D.S. 登録日 2023-01-05 公開日 2023-10-04 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (1.4 Å) 主引用文献 Structure-based design of nanobodies that inhibit seeding of Alzheimer's patient-extracted tau fibrils. Proc.Natl.Acad.Sci.USA, 120, 2023

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