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6PZC
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BU of 6pzc by Molmil
Cryo-EM structure of the pancreatic beta-cell SUR1 bound to carbamazepine
分子名称: ATP-binding cassette sub-family C member 8
著者Shyng, S.L, Yoshioka, C, Martin, G.M, Sung, M.W.
登録日2019-07-31
公開日2019-08-14
最終更新日2024-03-20
実験手法ELECTRON MICROSCOPY (4.34 Å)
主引用文献Mechanism of pharmacochaperoning in a mammalian K ATP channel revealed by cryo-EM.
Elife, 8, 2019
6QCD
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BU of 6qcd by Molmil
Human Sirt6 in complex with ADP-ribose and the activator quercetin
分子名称: 1,2-ETHANEDIOL, 3,5,7,3',4'-PENTAHYDROXYFLAVONE, NAD-dependent protein deacetylase sirtuin-6, ...
著者You, W, Steegborn, C.
登録日2018-12-27
公開日2019-12-25
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (1.84 Å)
主引用文献Structural basis for the activation and inhibition of Sirtuin 6 by quercetin and its derivatives.
Sci Rep, 9, 2019
6QCN
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BU of 6qcn by Molmil
Human Sirt2 in complex with ADP-ribose and the inhibitor quercetin
分子名称: 3,5,7,3',4'-PENTAHYDROXYFLAVONE, NAD-dependent protein deacetylase sirtuin-2, ZINC ION, ...
著者Riemer, S, You, W, Steegborn, C.
登録日2018-12-29
公開日2019-12-25
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (2.23 Å)
主引用文献Structural basis for the activation and inhibition of Sirtuin 6 by quercetin and its derivatives.
Sci Rep, 9, 2019
6N60
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BU of 6n60 by Molmil
Escherichia coli RNA polymerase sigma70-holoenzyme bound to upstream fork promoter DNA and Microcin J25 (MccJ25)
分子名称: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ...
著者Braffman, N, Hauver, J, Campbell, E.A, Darst, S.A.
登録日2018-11-23
公開日2019-01-09
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (3.68 Å)
主引用文献Structural mechanism of transcription inhibition by lasso peptides microcin J25 and capistruin.
Proc. Natl. Acad. Sci. U.S.A., 116, 2019
6WET
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BU of 6wet by Molmil
Crystal structures of human E-NPP 1: apo
分子名称: 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
著者Peat, T.S, Dennis, M, Newman, J.
登録日2020-04-02
公開日2020-09-09
最終更新日2024-11-13
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Crystal structures of human ENPP1 in apo and bound forms.
Acta Crystallogr D Struct Biol, 76, 2020
6OES
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BU of 6oes by Molmil
Cryo-EM structure of mouse RAG1/2 STC complex (without NBD domain)
分子名称: CALCIUM ION, DNA (34-MER), DNA (35-MER), ...
著者Chen, X, Cui, Y, Zhou, Z.H, Yang, W, Gellert, M.
登録日2019-03-27
公開日2020-01-22
最終更新日2025-05-14
実験手法ELECTRON MICROSCOPY (3.06 Å)
主引用文献How mouse RAG recombinase avoids DNA transposition.
Nat.Struct.Mol.Biol., 27, 2020
6O3B
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BU of 6o3b by Molmil
Crystal structure of Frizzled 7 CRD in complex with F6 Fab
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Antibody Fab F6, Heavy chain, ...
著者Raman, S, Beilschmidt, M, Fransson, J, Julien, J.P.
登録日2019-02-26
公開日2019-04-03
最終更新日2024-11-20
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Structure-guided design fine-tunes pharmacokinetics, tolerability, and antitumor profile of multispecific frizzled antibodies.
Proc. Natl. Acad. Sci. U.S.A., 116, 2019
6ONU
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BU of 6onu by Molmil
Complex structure of WhiB1 and region 4 of SigA in P21 space group.
分子名称: DI(HYDROXYETHYL)ETHER, IRON/SULFUR CLUSTER, RNA polymerase sigma factor SigA, ...
著者Wan, T, Li, S.R, Beltran, D.G, Schacht, A, Becker, D.C, Zhang, L.M.
登録日2019-04-22
公開日2019-11-27
最終更新日2024-10-23
実験手法X-RAY DIFFRACTION (1.85 Å)
主引用文献Structural basis of non-canonical transcriptional regulation by the sigma A-bound iron-sulfur protein WhiB1 in M. tuberculosis.
Nucleic Acids Res., 48, 2020
5HC0
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BU of 5hc0 by Molmil
Structure of esterase Est22 with p-nitrophenol
分子名称: ACETIC ACID, GLYCEROL, Lipolytic enzyme, ...
著者Li, J, Huang, J.
登録日2016-01-04
公開日2017-01-18
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (1.4 Å)
主引用文献Structural insights of a hormone sensitive lipase homologue Est22.
Sci Rep, 6, 2016
5VEX
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BU of 5vex by Molmil
Structure of the human GLP-1 receptor complex with NNC0640
分子名称: 4-{[(4-cyclohexylphenyl){[3-(methylsulfonyl)phenyl]carbamoyl}amino]methyl}-N-(1H-tetrazol-5-yl)benzamide, Glucagon-like peptide 1 receptor, Endolysin chimera
著者Song, G, Yang, D, Wang, Y, Graaf, C.D, Zhou, Q, Jiang, S, Liu, K, Cai, X, Dai, A, Lin, G, Liu, D, Wu, F, Wu, Y, Zhao, S, Ye, L, Han, G.W, Lau, J, Wu, B, Hanson, M.A, Liu, Z.-J, Wang, M.-W, Stevens, R.C.
登録日2017-04-05
公開日2017-05-17
最終更新日2024-10-30
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献Human GLP-1 receptor transmembrane domain structure in complex with allosteric modulators.
Nature, 546, 2017
6QCE
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BU of 6qce by Molmil
Human Sirt6 in complex with ADP-ribose and the activator isoquercetin
分子名称: 1,2-ETHANEDIOL, NAD-dependent protein deacetylase sirtuin-6, SULFATE ION, ...
著者You, W, Steegborn, C.
登録日2018-12-27
公開日2019-12-25
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Structural basis for the activation and inhibition of Sirtuin 6 by quercetin and its derivatives.
Sci Rep, 9, 2019
6QCH
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BU of 6qch by Molmil
Human Sirt6 in complex with ADP-ribose and the activator cyanidin
分子名称: 1,2-ETHANEDIOL, NAD-dependent protein deacetylase sirtuin-6, SULFATE ION, ...
著者You, W, Steegborn, C.
登録日2018-12-28
公開日2019-12-25
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Structural basis for the activation and inhibition of Sirtuin 6 by quercetin and its derivatives.
Sci Rep, 9, 2019
5VPA
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BU of 5vpa by Molmil
Transcription factor FosB/JunD bZIP domain
分子名称: CHLORIDE ION, Protein fosB, SODIUM ION, ...
著者Yin, Z, Machius, M, Rudenko, G.
登録日2017-05-04
公開日2017-09-06
最終更新日2024-10-09
実験手法X-RAY DIFFRACTION (2.83 Å)
主引用文献Activator Protein-1: redox switch controlling structure and DNA-binding.
Nucleic Acids Res., 45, 2017
5VPF
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BU of 5vpf by Molmil
Transcription factor FosB/JunD bZIP domain in complex with cognate DNA, type-II crystal
分子名称: 1,2-ETHANEDIOL, CHLORIDE ION, DNA (5'-D(*CP*GP*TP*CP*GP*GP*TP*GP*AP*CP*TP*CP*AP*CP*CP*GP*AP*CP*G)-3'), ...
著者Yin, Z, Rudenko, G, Machius, M.
登録日2017-05-04
公開日2017-09-06
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (2.694 Å)
主引用文献Activator Protein-1: redox switch controlling structure and DNA-binding.
Nucleic Acids Res., 45, 2017
5HLY
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BU of 5hly by Molmil
Structure of Pro-Activin A Precursor at 2.3 A Resolution
分子名称: CHLORIDE ION, Inhibin beta A chain
著者Wang, X, Fischer, G, Hyvonen, M.
登録日2016-01-15
公開日2016-07-13
最終更新日2024-11-20
実験手法X-RAY DIFFRACTION (2.302 Å)
主引用文献Structure and activation of pro-activin A.
Nat Commun, 7, 2016
6O3A
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BU of 6o3a by Molmil
Crystal structure of Frizzled 7 CRD in complex with F7.B Fab
分子名称: 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, 3-CYCLOHEXYL-1-PROPYLSULFONIC ACID, ...
著者Raman, S, Beilschmidt, M, Fransson, J, Julien, J.P.
登録日2019-02-26
公開日2019-04-03
最終更新日2024-11-20
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Structure-guided design fine-tunes pharmacokinetics, tolerability, and antitumor profile of multispecific frizzled antibodies.
Proc. Natl. Acad. Sci. U.S.A., 116, 2019
6O39
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BU of 6o39 by Molmil
Crystal structure of Frizzled 5 CRD in complex with F2.I Fab
分子名称: 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, ACETATE ION, ...
著者Raman, S, Beilschmidt, M, Fransson, J, Julien, J.P.
登録日2019-02-26
公開日2019-04-03
最終更新日2024-11-20
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Structure-guided design fine-tunes pharmacokinetics, tolerability, and antitumor profile of multispecific frizzled antibodies.
Proc. Natl. Acad. Sci. U.S.A., 116, 2019
6OEO
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BU of 6oeo by Molmil
Cryo-EM structure of mouse RAG1/2 NFC complex (DNA1)
分子名称: CALCIUM ION, DNA (46-MER), DNA (57-MER), ...
著者Chen, X, Cui, Y, Zhou, Z.H, Yang, W, Gellert, M.
登録日2019-03-27
公開日2020-01-29
最終更新日2025-06-04
実験手法ELECTRON MICROSCOPY (3.69 Å)
主引用文献Cutting antiparallel DNA strands in a single active site.
Nat.Struct.Mol.Biol., 27, 2020
7MQA
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BU of 7mqa by Molmil
Cryo-EM structure of the human SSU processome, state post-A1
分子名称: 18S rRNA, 40S ribosomal protein S11, 40S ribosomal protein S12, ...
著者Vanden Broeck, A, Singh, S, Klinge, S.
登録日2021-05-05
公開日2021-09-22
最終更新日2024-10-30
実験手法ELECTRON MICROSCOPY (2.7 Å)
主引用文献Nucleolar maturation of the human small subunit processome.
Science, 373, 2021
5HSP
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BU of 5hsp by Molmil
MamM CTD M250L
分子名称: Magnetosome protein MamM, SULFATE ION
著者Barber-Zucker, S, Zarivach, R.
登録日2016-01-26
公開日2016-11-30
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (1.79 Å)
主引用文献Disease-Homologous Mutation in the Cation Diffusion Facilitator Protein MamM Causes Single-Domain Structural Loss and Signifies Its Importance.
Sci Rep, 6, 2016
5NFL
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BU of 5nfl by Molmil
Crystal structure of YrbA from Sinorhizobium meliloti in complex with cobalt.
分子名称: COBALT (II) ION, YrbA
著者Roret, T, Didierjean, C.
登録日2017-03-14
公開日2018-10-10
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (1.903 Å)
主引用文献Sinorhizobium meliloti YrbA binds divalent metal cations using two conserved histidines.
Biosci.Rep., 40, 2020
5HC3
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BU of 5hc3 by Molmil
The structure of esterase Est22
分子名称: GLYCEROL, Lipolytic enzyme
著者Li, J, Huang, J.
登録日2016-01-04
公開日2017-01-18
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Structural insights of a hormone sensitive lipase homologue Est22.
Sci Rep, 6, 2016
5NJ8
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BU of 5nj8 by Molmil
Structural basis for aryl hydrocarbon receptor mediated gene activation
分子名称: ACETATE ION, Aryl hydrocarbon receptor, Aryl hydrocarbon receptor nuclear translocator, ...
著者Daumke, O, Schulte, K.W.
登録日2017-03-28
公開日2017-06-28
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (3.3 Å)
主引用文献Structural Basis for Aryl Hydrocarbon Receptor-Mediated Gene Activation.
Structure, 25, 2017
6NPK
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BU of 6npk by Molmil
Structure of the TM domain
分子名称: Solute carrier family 12 (sodium/potassium/chloride transporter), member 2
著者Feng, L, Liao, M.F, Orlando, B, Zhang, J.R.
登録日2019-01-17
公開日2019-07-31
最終更新日2024-10-23
実験手法ELECTRON MICROSCOPY (3.6 Å)
主引用文献Structure and mechanism of the cation-chloride cotransporter NKCC1.
Nature, 572, 2019
6NTS
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BU of 6nts by Molmil
Protein Phosphatase 2A (Aalpha-B56alpha-Calpha) holoenzyme in complex with a Small Molecule Activator of PP2A (SMAP)
分子名称: MANGANESE (II) ION, N-[(1R,2R,3S)-2-hydroxy-3-(10H-phenoxazin-10-yl)cyclohexyl]-4-(trifluoromethoxy)benzene-1-sulfonamide, Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform, ...
著者Huang, W, Taylor, D.
登録日2019-01-30
公開日2020-05-06
最終更新日2025-06-04
実験手法ELECTRON MICROSCOPY (3.63 Å)
主引用文献Selective PP2A Enhancement through Biased Heterotrimer Stabilization.
Cell, 181, 2020

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件を2025-07-09に公開中

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