6PZC
 
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6QCD
 
 | Human Sirt6 in complex with ADP-ribose and the activator quercetin | 分子名称: | 1,2-ETHANEDIOL, 3,5,7,3',4'-PENTAHYDROXYFLAVONE, NAD-dependent protein deacetylase sirtuin-6, ... | 著者 | You, W, Steegborn, C. | 登録日 | 2018-12-27 | 公開日 | 2019-12-25 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.84 Å) | 主引用文献 | Structural basis for the activation and inhibition of Sirtuin 6 by quercetin and its derivatives. Sci Rep, 9, 2019
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6QCN
 
 | Human Sirt2 in complex with ADP-ribose and the inhibitor quercetin | 分子名称: | 3,5,7,3',4'-PENTAHYDROXYFLAVONE, NAD-dependent protein deacetylase sirtuin-2, ZINC ION, ... | 著者 | Riemer, S, You, W, Steegborn, C. | 登録日 | 2018-12-29 | 公開日 | 2019-12-25 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (2.23 Å) | 主引用文献 | Structural basis for the activation and inhibition of Sirtuin 6 by quercetin and its derivatives. Sci Rep, 9, 2019
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6N60
 
 | Escherichia coli RNA polymerase sigma70-holoenzyme bound to upstream fork promoter DNA and Microcin J25 (MccJ25) | 分子名称: | DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... | 著者 | Braffman, N, Hauver, J, Campbell, E.A, Darst, S.A. | 登録日 | 2018-11-23 | 公開日 | 2019-01-09 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (3.68 Å) | 主引用文献 | Structural mechanism of transcription inhibition by lasso peptides microcin J25 and capistruin. Proc. Natl. Acad. Sci. U.S.A., 116, 2019
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6WET
 
 | Crystal structures of human E-NPP 1: apo | 分子名称: | 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Peat, T.S, Dennis, M, Newman, J. | 登録日 | 2020-04-02 | 公開日 | 2020-09-09 | 最終更新日 | 2024-11-13 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Crystal structures of human ENPP1 in apo and bound forms. Acta Crystallogr D Struct Biol, 76, 2020
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6OES
 
 | Cryo-EM structure of mouse RAG1/2 STC complex (without NBD domain) | 分子名称: | CALCIUM ION, DNA (34-MER), DNA (35-MER), ... | 著者 | Chen, X, Cui, Y, Zhou, Z.H, Yang, W, Gellert, M. | 登録日 | 2019-03-27 | 公開日 | 2020-01-22 | 最終更新日 | 2025-05-14 | 実験手法 | ELECTRON MICROSCOPY (3.06 Å) | 主引用文献 | How mouse RAG recombinase avoids DNA transposition. Nat.Struct.Mol.Biol., 27, 2020
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6O3B
 
 | Crystal structure of Frizzled 7 CRD in complex with F6 Fab | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Antibody Fab F6, Heavy chain, ... | 著者 | Raman, S, Beilschmidt, M, Fransson, J, Julien, J.P. | 登録日 | 2019-02-26 | 公開日 | 2019-04-03 | 最終更新日 | 2024-11-20 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Structure-guided design fine-tunes pharmacokinetics, tolerability, and antitumor profile of multispecific frizzled antibodies. Proc. Natl. Acad. Sci. U.S.A., 116, 2019
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6ONU
 
 | Complex structure of WhiB1 and region 4 of SigA in P21 space group. | 分子名称: | DI(HYDROXYETHYL)ETHER, IRON/SULFUR CLUSTER, RNA polymerase sigma factor SigA, ... | 著者 | Wan, T, Li, S.R, Beltran, D.G, Schacht, A, Becker, D.C, Zhang, L.M. | 登録日 | 2019-04-22 | 公開日 | 2019-11-27 | 最終更新日 | 2024-10-23 | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | 主引用文献 | Structural basis of non-canonical transcriptional regulation by the sigma A-bound iron-sulfur protein WhiB1 in M. tuberculosis. Nucleic Acids Res., 48, 2020
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5HC0
 
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5VEX
 
 | Structure of the human GLP-1 receptor complex with NNC0640 | 分子名称: | 4-{[(4-cyclohexylphenyl){[3-(methylsulfonyl)phenyl]carbamoyl}amino]methyl}-N-(1H-tetrazol-5-yl)benzamide, Glucagon-like peptide 1 receptor, Endolysin chimera | 著者 | Song, G, Yang, D, Wang, Y, Graaf, C.D, Zhou, Q, Jiang, S, Liu, K, Cai, X, Dai, A, Lin, G, Liu, D, Wu, F, Wu, Y, Zhao, S, Ye, L, Han, G.W, Lau, J, Wu, B, Hanson, M.A, Liu, Z.-J, Wang, M.-W, Stevens, R.C. | 登録日 | 2017-04-05 | 公開日 | 2017-05-17 | 最終更新日 | 2024-10-30 | 実験手法 | X-RAY DIFFRACTION (3 Å) | 主引用文献 | Human GLP-1 receptor transmembrane domain structure in complex with allosteric modulators. Nature, 546, 2017
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6QCE
 
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6QCH
 
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5VPA
 
 | Transcription factor FosB/JunD bZIP domain | 分子名称: | CHLORIDE ION, Protein fosB, SODIUM ION, ... | 著者 | Yin, Z, Machius, M, Rudenko, G. | 登録日 | 2017-05-04 | 公開日 | 2017-09-06 | 最終更新日 | 2024-10-09 | 実験手法 | X-RAY DIFFRACTION (2.83 Å) | 主引用文献 | Activator Protein-1: redox switch controlling structure and DNA-binding. Nucleic Acids Res., 45, 2017
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5VPF
 
 | Transcription factor FosB/JunD bZIP domain in complex with cognate DNA, type-II crystal | 分子名称: | 1,2-ETHANEDIOL, CHLORIDE ION, DNA (5'-D(*CP*GP*TP*CP*GP*GP*TP*GP*AP*CP*TP*CP*AP*CP*CP*GP*AP*CP*G)-3'), ... | 著者 | Yin, Z, Rudenko, G, Machius, M. | 登録日 | 2017-05-04 | 公開日 | 2017-09-06 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (2.694 Å) | 主引用文献 | Activator Protein-1: redox switch controlling structure and DNA-binding. Nucleic Acids Res., 45, 2017
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5HLY
 
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6O3A
 
 | Crystal structure of Frizzled 7 CRD in complex with F7.B Fab | 分子名称: | 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, 3-CYCLOHEXYL-1-PROPYLSULFONIC ACID, ... | 著者 | Raman, S, Beilschmidt, M, Fransson, J, Julien, J.P. | 登録日 | 2019-02-26 | 公開日 | 2019-04-03 | 最終更新日 | 2024-11-20 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Structure-guided design fine-tunes pharmacokinetics, tolerability, and antitumor profile of multispecific frizzled antibodies. Proc. Natl. Acad. Sci. U.S.A., 116, 2019
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6O39
 
 | Crystal structure of Frizzled 5 CRD in complex with F2.I Fab | 分子名称: | 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, ACETATE ION, ... | 著者 | Raman, S, Beilschmidt, M, Fransson, J, Julien, J.P. | 登録日 | 2019-02-26 | 公開日 | 2019-04-03 | 最終更新日 | 2024-11-20 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Structure-guided design fine-tunes pharmacokinetics, tolerability, and antitumor profile of multispecific frizzled antibodies. Proc. Natl. Acad. Sci. U.S.A., 116, 2019
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6OEO
 
 | Cryo-EM structure of mouse RAG1/2 NFC complex (DNA1) | 分子名称: | CALCIUM ION, DNA (46-MER), DNA (57-MER), ... | 著者 | Chen, X, Cui, Y, Zhou, Z.H, Yang, W, Gellert, M. | 登録日 | 2019-03-27 | 公開日 | 2020-01-29 | 最終更新日 | 2025-06-04 | 実験手法 | ELECTRON MICROSCOPY (3.69 Å) | 主引用文献 | Cutting antiparallel DNA strands in a single active site. Nat.Struct.Mol.Biol., 27, 2020
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7MQA
 
 | Cryo-EM structure of the human SSU processome, state post-A1 | 分子名称: | 18S rRNA, 40S ribosomal protein S11, 40S ribosomal protein S12, ... | 著者 | Vanden Broeck, A, Singh, S, Klinge, S. | 登録日 | 2021-05-05 | 公開日 | 2021-09-22 | 最終更新日 | 2024-10-30 | 実験手法 | ELECTRON MICROSCOPY (2.7 Å) | 主引用文献 | Nucleolar maturation of the human small subunit processome. Science, 373, 2021
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5HSP
 
 | MamM CTD M250L | 分子名称: | Magnetosome protein MamM, SULFATE ION | 著者 | Barber-Zucker, S, Zarivach, R. | 登録日 | 2016-01-26 | 公開日 | 2016-11-30 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (1.79 Å) | 主引用文献 | Disease-Homologous Mutation in the Cation Diffusion Facilitator Protein MamM Causes Single-Domain Structural Loss and Signifies Its Importance. Sci Rep, 6, 2016
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5NFL
 
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5HC3
 
 | The structure of esterase Est22 | 分子名称: | GLYCEROL, Lipolytic enzyme | 著者 | Li, J, Huang, J. | 登録日 | 2016-01-04 | 公開日 | 2017-01-18 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Structural insights of a hormone sensitive lipase homologue Est22. Sci Rep, 6, 2016
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5NJ8
 
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6NPK
 
 | Structure of the TM domain | 分子名称: | Solute carrier family 12 (sodium/potassium/chloride transporter), member 2 | 著者 | Feng, L, Liao, M.F, Orlando, B, Zhang, J.R. | 登録日 | 2019-01-17 | 公開日 | 2019-07-31 | 最終更新日 | 2024-10-23 | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | 主引用文献 | Structure and mechanism of the cation-chloride cotransporter NKCC1. Nature, 572, 2019
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6NTS
 
 | Protein Phosphatase 2A (Aalpha-B56alpha-Calpha) holoenzyme in complex with a Small Molecule Activator of PP2A (SMAP) | 分子名称: | MANGANESE (II) ION, N-[(1R,2R,3S)-2-hydroxy-3-(10H-phenoxazin-10-yl)cyclohexyl]-4-(trifluoromethoxy)benzene-1-sulfonamide, Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform, ... | 著者 | Huang, W, Taylor, D. | 登録日 | 2019-01-30 | 公開日 | 2020-05-06 | 最終更新日 | 2025-06-04 | 実験手法 | ELECTRON MICROSCOPY (3.63 Å) | 主引用文献 | Selective PP2A Enhancement through Biased Heterotrimer Stabilization. Cell, 181, 2020
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