7OJN
 
 | | Lassa virus L protein in an elongation conformation [ELONGATION] | | 分子名称: | 3' RNA, 5' RNA, 5'-O-[(S)-hydroxy{[(S)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]uridine, ... | | 著者 | Kouba, T, Vogel, D, Thorkelsson, S, Quemin, E, Williams, H.M, Milewski, M, Busch, C, Gunther, S, Grunewald, K, Rosenthal, M, Cusack, S. | | 登録日 | 2021-05-16 | | 公開日 | 2021-12-01 | | 最終更新日 | 2024-05-01 | | 実験手法 | ELECTRON MICROSCOPY (2.92 Å) | | 主引用文献 | Conformational changes in Lassa virus L protein associated with promoter binding and RNA synthesis activity.
Nat Commun, 12, 2021
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7OJL
 | | Lassa virus L protein in a pre-initiation conformation [PREINITIATION] | | 分子名称: | 3' RNA, 5' RNA, MANGANESE (II) ION, ... | | 著者 | Kouba, T, Vogel, D, Thorkelsson, S, Quemin, E, Williams, H.M, Milewski, M, Busch, C, Gunther, S, Grunewald, K, Rosenthal, M, Cusack, S. | | 登録日 | 2021-05-16 | | 公開日 | 2021-12-01 | | 最終更新日 | 2024-05-01 | | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | | 主引用文献 | Conformational changes in Lassa virus L protein associated with promoter binding and RNA synthesis activity.
Nat Commun, 12, 2021
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5IY7
 | | Human holo-PIC in the open state | | 分子名称: | DNA-directed RNA polymerase II subunit RPB1, DNA-directed RNA polymerase II subunit RPB10, DNA-directed RNA polymerase II subunit RPB11-a, ... | | 著者 | He, Y, Yan, C, Fang, J, Inouye, C, Tjian, R, Ivanov, I, Nogales, E. | | 登録日 | 2016-03-24 | | 公開日 | 2016-05-18 | | 最終更新日 | 2024-03-06 | | 実験手法 | ELECTRON MICROSCOPY (8.6 Å) | | 主引用文献 | Near-atomic resolution visualization of human transcription promoter opening.
Nature, 533, 2016
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6IPF
 | | Post-catalytic Complex of Human DNA Polymerase Mu with Templating Cytosine and Mn-8oxodGMP | | 分子名称: | 1,2-ETHANEDIOL, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, CHLORIDE ION, ... | | 著者 | Chang, Y.K, Wu, W.J, Tsai, M.D. | | 登録日 | 2018-11-03 | | 公開日 | 2019-05-29 | | 最終更新日 | 2024-03-27 | | 実験手法 | X-RAY DIFFRACTION (1.77 Å) | | 主引用文献 | Human DNA Polymerase mu Can Use a Noncanonical Mechanism for Multiple Mn2+-Mediated Functions.
J.Am.Chem.Soc., 141, 2019
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6IPD
 | | Post-catalytic Complex of Human DNA Polymerase Mu with Templating Adenine and Mn-8oxodGMP | | 分子名称: | 1,2-ETHANEDIOL, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, DNA (5'-D(*CP*GP*GP*CP*AP*TP*AP*CP*G)-3'), ... | | 著者 | Chang, Y.K, Wu, W.J, Tsai, M.D. | | 登録日 | 2018-11-03 | | 公開日 | 2019-05-29 | | 最終更新日 | 2024-03-27 | | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | | 主引用文献 | Human DNA Polymerase mu Can Use a Noncanonical Mechanism for Multiple Mn2+-Mediated Functions.
J.Am.Chem.Soc., 141, 2019
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6IPI
 | | Binary Complex of Human DNA Polymerase Mu with MndCTP | | 分子名称: | 2'-DEOXYCYTIDINE-5'-TRIPHOSPHATE, DNA-directed DNA/RNA polymerase mu, MANGANESE (II) ION, ... | | 著者 | Chang, Y.K, Wu, W.J, Tsai, M.D. | | 登録日 | 2018-11-03 | | 公開日 | 2019-05-29 | | 最終更新日 | 2024-03-27 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Human DNA Polymerase mu Can Use a Noncanonical Mechanism for Multiple Mn2+-Mediated Functions.
J.Am.Chem.Soc., 141, 2019
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7LBM
 | | Structure of the human Mediator-bound transcription pre-initiation complex | | 分子名称: | CDK-activating kinase assembly factor MAT1, Cyclin-H, Cyclin-dependent kinase 7, ... | | 著者 | Abdella, R, Talyzina, A, He, Y. | | 登録日 | 2021-01-08 | | 公開日 | 2021-03-24 | | 最終更新日 | 2021-04-14 | | 実験手法 | ELECTRON MICROSCOPY (4.8 Å) | | 主引用文献 | Structure of the human Mediator-bound transcription preinitiation complex.
Science, 372, 2021
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5IY8
 | | Human holo-PIC in the initial transcribing state | | 分子名称: | DNA-directed RNA polymerase II subunit RPB1, DNA-directed RNA polymerase II subunit RPB10, DNA-directed RNA polymerase II subunit RPB11-a, ... | | 著者 | He, Y, Yan, C, Fang, J, Inouye, C, Tjian, R, Ivanov, I, Nogales, E. | | 登録日 | 2016-03-24 | | 公開日 | 2016-05-18 | | 最終更新日 | 2024-03-06 | | 実験手法 | ELECTRON MICROSCOPY (7.9 Å) | | 主引用文献 | Near-atomic resolution visualization of human transcription promoter opening.
Nature, 533, 2016
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5IY6
 | | Human holo-PIC in the closed state | | 分子名称: | DNA-directed RNA polymerase II subunit RPB1, DNA-directed RNA polymerase II subunit RPB10, DNA-directed RNA polymerase II subunit RPB11-a, ... | | 著者 | He, Y, Yan, C, Fang, J, Inouye, C, Tjian, R, Ivanov, I, Nogales, E. | | 登録日 | 2016-03-24 | | 公開日 | 2016-05-18 | | 最終更新日 | 2019-11-20 | | 実験手法 | ELECTRON MICROSCOPY (7.2 Å) | | 主引用文献 | Near-atomic resolution visualization of human transcription promoter opening.
Nature, 533, 2016
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7UND
 | | Pol II-DSIF-SPT6-PAF1c-TFIIS-nucleosome complex (stalled at +38) | | 分子名称: | DNA-directed RNA polymerase II subunit E, DNA-directed RNA polymerase II subunit RPB3, DNA-directed RNA polymerase II subunit RPB7, ... | | 著者 | Filipovski, M, Vos, S.M, Farnung, L. | | 登録日 | 2022-04-10 | | 公開日 | 2022-10-19 | | 実験手法 | ELECTRON MICROSCOPY (3 Å) | | 主引用文献 | Structural basis of nucleosome retention during transcription elongation.
Science, 376, 2022
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7UNC
 | | Pol II-DSIF-SPT6-PAF1c-TFIIS complex with rewrapped nucleosome | | 分子名称: | DNA-directed RNA polymerase II subunit E, DNA-directed RNA polymerase II subunit RPB3, DNA-directed RNA polymerase II subunit RPB7, ... | | 著者 | Filipovski, M, Vos, S.M, Farnung, L. | | 登録日 | 2022-04-10 | | 公開日 | 2022-10-19 | | 実験手法 | ELECTRON MICROSCOPY (3 Å) | | 主引用文献 | Structural basis of nucleosome retention during transcription elongation.
Science, 376, 2022
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6P1S
 | | Post-catalytic nicked complex of human DNA Polymerase Mu with 1-nt gapped substrate containing template 8OG and newly incorporated AMP | | 分子名称: | 1,2-ETHANEDIOL, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ADENOSINE-5'-TRIPHOSPHATE, ... | | 著者 | Kaminski, A.M, Pedersen, L.C, Bebenek, K, Chiruvella, K.K, Ramsden, D.A, Kunkel, T.A. | | 登録日 | 2019-05-20 | | 公開日 | 2019-09-04 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | | 主引用文献 | Unexpected behavior of DNA polymerase Mu opposite template 8-oxo-7,8-dihydro-2'-guanosine.
Nucleic Acids Res., 47, 2019
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6P1U
 | | Post-catalytic nicked complex of human DNA Polymerase Mu with 1-nt gapped substrate containing template 8OG and newly incorporated CMP | | 分子名称: | 1,2-ETHANEDIOL, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, CHLORIDE ION, ... | | 著者 | Kaminski, A.M, Pedersen, L.C, Bebenek, K, Chiruvella, K.K, Ramsden, D.A, Kunkel, T.A. | | 登録日 | 2019-05-20 | | 公開日 | 2019-09-04 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | | 主引用文献 | Unexpected behavior of DNA polymerase Mu opposite template 8-oxo-7,8-dihydro-2'-guanosine.
Nucleic Acids Res., 47, 2019
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8B3F
 | | Pol II-CSB-CSA-DDB1-ELOF1 | | 分子名称: | DNA damage-binding protein 1, DNA excision repair protein ERCC-6, DNA excision repair protein ERCC-8, ... | | 著者 | Kokic, G, Cramer, P. | | 登録日 | 2022-09-16 | | 公開日 | 2023-09-27 | | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | | 主引用文献 | Pol II-CSB-CSA-DDB1-ELOF1 structure.
To Be Published
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8B3D
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5OQM
 | | STRUCTURE OF YEAST TRANSCRIPTION PRE-INITIATION COMPLEX WITH TFIIH AND CORE MEDIATOR | | 分子名称: | DNA-directed RNA polymerase II subunit RPB1, DNA-directed RNA polymerase II subunit RPB11, DNA-directed RNA polymerase II subunit RPB2, ... | | 著者 | Schilbach, S, Hantsche, M, Tegunov, D, Dienemann, C, Wigge, C, Urlaub, H, Cramer, P. | | 登録日 | 2017-08-13 | | 公開日 | 2018-05-09 | | 最終更新日 | 2024-05-15 | | 実験手法 | ELECTRON MICROSCOPY (5.8 Å) | | 主引用文献 | Structures of transcription pre-initiation complex with TFIIH and Mediator.
Nature, 551, 2017
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5OQJ
 | | STRUCTURE OF YEAST TRANSCRIPTION PRE-INITIATION COMPLEX WITH TFIIH | | 分子名称: | DNA repair helicase RAD25, DNA repair helicase RAD3, DNA-directed RNA polymerase II subunit RPB1, ... | | 著者 | Schilbach, S, Hantsche, M, Tegunov, D, Dienemann, C, Wigge, C, Henning, U, Cramer, P. | | 登録日 | 2017-08-11 | | 公開日 | 2018-04-25 | | 最終更新日 | 2024-05-15 | | 実験手法 | ELECTRON MICROSCOPY (4.7 Å) | | 主引用文献 | Structures of transcription pre-initiation complex with TFIIH and Mediator.
Nature, 551, 2017
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5TYV
 | | DNA Polymerase Mu Reactant Complex, Mn2+ (7.5 min) | | 分子名称: | 1,2-ETHANEDIOL, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, DNA (5'-D(*CP*GP*GP*CP*AP*TP*AP*CP*G)-3'), ... | | 著者 | Jamsen, J.A, Wilson, S.H. | | 登録日 | 2016-11-21 | | 公開日 | 2017-08-30 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (1.93 Å) | | 主引用文献 | Time-lapse crystallography snapshots of a double-strand break repair polymerase in action.
Nat Commun, 8, 2017
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5TYY
 | | DNA Polymerase Mu Product Complex, Mn2+ (60 min) | | 分子名称: | 1,2-ETHANEDIOL, 2,3-DIHYDROXY-1,4-DITHIOBUTANE, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ... | | 著者 | Jamsen, J.A, Wilson, S.H. | | 登録日 | 2016-11-21 | | 公開日 | 2017-08-30 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (1.931 Å) | | 主引用文献 | Time-lapse crystallography snapshots of a double-strand break repair polymerase in action.
Nat Commun, 8, 2017
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7UIF
 | | Mediator-PIC Early (Core B) | | 分子名称: | DNA-directed RNA polymerase II subunit RPB1, DNA-directed RNA polymerase II subunit RPB11, DNA-directed RNA polymerase II subunit RPB2, ... | | 著者 | Gorbea Colon, J.J, Chen, S.-F, Tsai, K.L, Murakami, K. | | 登録日 | 2022-03-29 | | 公開日 | 2023-02-15 | | 最終更新日 | 2023-03-08 | | 実験手法 | ELECTRON MICROSCOPY (4.6 Å) | | 主引用文献 | Structural basis of a transcription pre-initiation complex on a divergent promoter.
Mol.Cell, 83, 2023
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7UIO
 | | Mediator-PIC Early (Composite Model) | | 分子名称: | ALANINE, ASPARTIC ACID, DNA (37-MER), ... | | 著者 | Gorbea Colon, J.J, Chen, S.-F, Tsai, K.L, Murakami, K. | | 登録日 | 2022-03-29 | | 公開日 | 2023-03-01 | | 最終更新日 | 2024-06-12 | | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | | 主引用文献 | Structural basis of a transcription pre-initiation complex on a divergent promoter.
Mol.Cell, 83, 2023
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7UI9
 | | Core Mediator-PICearly (Copy A) | | 分子名称: | DNA-directed RNA polymerase II subunit RPB1, DNA-directed RNA polymerase II subunit RPB11, DNA-directed RNA polymerase II subunit RPB2, ... | | 著者 | Gorbea Colon, J.J, Chen, S.-F, Tsai, K.L, Murakami, K. | | 登録日 | 2022-03-28 | | 公開日 | 2023-02-15 | | 最終更新日 | 2023-03-08 | | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | | 主引用文献 | Structural basis of a transcription pre-initiation complex on a divergent promoter.
Mol.Cell, 83, 2023
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7EGC
 | | p53-bound TFIID-based holo PIC on HDM2 promoter | | 分子名称: | CDK-activating kinase assembly factor MAT1, Cyclin-H, Cyclin-dependent kinase 7, ... | | 著者 | Chen, X, Wu, Z, Hou, H, Qi, Y, Wang, X, Li, J, Xu, Y. | | 登録日 | 2021-03-24 | | 公開日 | 2021-05-12 | | 実験手法 | ELECTRON MICROSCOPY (3.9 Å) | | 主引用文献 | Structural insights into preinitiation complex assembly on core promoters.
Science, 372, 2021
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5IYA
 | | Human core-PIC in the closed state | | 分子名称: | DNA-directed RNA polymerase II subunit RPB1, DNA-directed RNA polymerase II subunit RPB10, DNA-directed RNA polymerase II subunit RPB11-a, ... | | 著者 | He, Y, Yan, C, Fang, J, Inouye, C, Tjian, R, Ivanov, I, Nogales, E. | | 登録日 | 2016-03-24 | | 公開日 | 2016-05-18 | | 最終更新日 | 2019-11-20 | | 実験手法 | ELECTRON MICROSCOPY (5.4 Å) | | 主引用文献 | Near-atomic resolution visualization of human transcription promoter opening.
Nature, 533, 2016
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5IYC
 | | Human core-PIC in the initial transcribing state | | 分子名称: | DNA-directed RNA polymerase II subunit RPB1, DNA-directed RNA polymerase II subunit RPB10, DNA-directed RNA polymerase II subunit RPB11-a, ... | | 著者 | He, Y, Yan, C, Fang, J, Inouye, C, Tjian, R, Ivanov, I, Nogales, E. | | 登録日 | 2016-03-24 | | 公開日 | 2016-05-18 | | 最終更新日 | 2024-03-06 | | 実験手法 | ELECTRON MICROSCOPY (3.9 Å) | | 主引用文献 | Near-atomic resolution visualization of human transcription promoter opening.
Nature, 533, 2016
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