9J8M
 
 | | Cryo-EM structure of BAF-Lamin A/C IgF-nucleosome complex (High mobility complex) | | 分子名称: | Barrier-to-autointegration factor, DNA (193-MER), Histone H2A type 1-B/E, ... | | 著者 | Horikoshi, N, Miyake, R, Sogawa-Fujiwara, C, Ogasawara, M, Takizawa, Y, Kurumizaka, H. | | 登録日 | 2024-08-21 | | 公開日 | 2025-02-26 | | 最終更新日 | 2025-07-02 | | 実験手法 | ELECTRON MICROSCOPY (3.82 Å) | | 主引用文献 | Cryo-EM structures of the BAF-Lamin A/C complex bound to nucleosomes.
Nat Commun, 16, 2025
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1YVZ
 | | Hepatitis C Virus RNA Polymerase Genotype 2a In Complex With Non- Nucleoside Analogue Inhibitor | | 分子名称: | 3-[(2,4-DICHLOROBENZOYL)(ISOPROPYL)AMINO]-5-PHENYLTHIOPHENE-2-CARBOXYLIC ACID, RNA dependent RNA polymerase, SULFATE ION | | 著者 | Biswal, B.K, Cherney, M.M, Wang, M, Chan, L, Yannopoulos, C.G, Bilimoria, D, Nicolas, O, Bedard, J, James, M.N.G. | | 登録日 | 2005-02-16 | | 公開日 | 2005-03-22 | | 最終更新日 | 2024-10-30 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Crystal structures of the RNA dependent RNA polymerase genotype 2a of hepatitis C virus reveal two conformations and suggest mechanisms of inhibition by non-nucleoside inhibitors.
J.Biol.Chem., 280, 2005
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1YBF
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3K8O
 | | Crystal structure of human purine nucleoside phosphorylase in complex with DATMe-ImmH | | 分子名称: | 7-({[(1R,2S)-2,3-DIHYDROXY-1-(HYDROXYMETHYL)PROPYL]AMINO}METHYL)-3,5-DIHYDRO-4H-PYRROLO[3,2-D]PYRIMIDIN-4-ONE, Purine nucleoside phosphorylase, SULFATE ION | | 著者 | Ho, M, Rinaldo-matthis, A, Almo, S.C, Schramm, V.L. | | 登録日 | 2009-10-14 | | 公開日 | 2010-03-02 | | 最終更新日 | 2024-02-21 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Crystal structure of human purine nucleoside phosphorylase in complex with DATMe-Immucillin H
Proc.Natl.Acad.Sci.USA, 2010
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8HXZ
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7Y8R
 | | The nucleosome-bound human PBAF complex | | 分子名称: | ACTB protein (Fragment), ADENOSINE-5'-DIPHOSPHATE, AT-rich interactive domain-containing protein 2, ... | | 著者 | Wang, L, Yu, J, Yu, Z, Wang, Q, He, S, Xu, Y. | | 登録日 | 2022-06-24 | | 公開日 | 2022-12-07 | | 最終更新日 | 2024-07-03 | | 実験手法 | ELECTRON MICROSCOPY (4.4 Å) | | 主引用文献 | Structure of nucleosome-bound human PBAF complex.
Nat Commun, 13, 2022
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1KFD
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9L5T
 | | Cryo-EM structure of the thermophile spliceosome (state B*Q2) | | 分子名称: | Anaphase-promoting complex subunit 4-like WD40 domain-containing protein, CCDC12, Delta(14)-sterol reductase, ... | | 著者 | Li, Y, Fischer, P, Wang, M, Yuan, R, Meng, W, Luehrmann, R, Lau, B, Hurt, E, Cheng, J. | | 登録日 | 2024-12-23 | | 公開日 | 2025-03-12 | | 最終更新日 | 2025-04-16 | | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | | 主引用文献 | Structural insights into spliceosome fidelity: DHX35-GPATCH1- mediated rejection of aberrant splicing substrates.
Cell Res., 35, 2025
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9L5S
 | | Cryo-EM structure of the thermophile spliceosome (state B*Q1) | | 分子名称: | Anaphase-promoting complex subunit 4-like WD40 domain-containing protein, CCDC12, Delta(14)-sterol reductase, ... | | 著者 | Li, Y, Fischer, P, Wang, M, Yuan, R, Meng, W, Luehrmann, R, Lau, B, Hurt, E, Cheng, J. | | 登録日 | 2024-12-23 | | 公開日 | 2025-03-12 | | 最終更新日 | 2025-04-16 | | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | | 主引用文献 | Structural insights into spliceosome fidelity: DHX35-GPATCH1- mediated rejection of aberrant splicing substrates.
Cell Res., 35, 2025
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9L5R
 | | Cryo-EM structure of the thermophile spliceosome (state ILS) | | 分子名称: | Anaphase-promoting complex subunit 4-like WD40 domain-containing protein, CCDC12, Cell cycle control protein, ... | | 著者 | Li, Y, Fischer, P, Wang, M, Yuan, R, Meng, W, Luehrmann, R, Lau, B, Hurt, E, Cheng, J. | | 登録日 | 2024-12-23 | | 公開日 | 2025-03-12 | | 最終更新日 | 2025-04-16 | | 実験手法 | ELECTRON MICROSCOPY (2.8 Å) | | 主引用文献 | Structural insights into spliceosome fidelity: DHX35-GPATCH1- mediated rejection of aberrant splicing substrates.
Cell Res., 35, 2025
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9B3P
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8V6V
 | | Cryo-EM structure of doubly-bound SNF2h-nucleosome complex | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, Histone H2A type 1, Histone H2B, ... | | 著者 | Chio, U.S, Palovcak, E, Armache, J.P, Narlikar, G.J, Cheng, Y. | | 登録日 | 2023-12-03 | | 公開日 | 2024-03-20 | | 実験手法 | ELECTRON MICROSCOPY (2.8 Å) | | 主引用文献 | Functionalized graphene-oxide grids enable high-resolution cryo-EM structures of the SNF2h-nucleosome complex without crosslinking.
Nat Commun, 15, 2024
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8V4Y
 | | Cryo-EM structure of singly-bound SNF2h-nucleosome complex with SNF2h at inactive SHL2 (conformation 1) | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, BERYLLIUM TRIFLUORIDE ION, Histone H2A type 1, ... | | 著者 | Chio, U.S, Palovcak, E, Armache, J.P, Narlikar, G.J, Cheng, Y. | | 登録日 | 2023-11-29 | | 公開日 | 2024-03-20 | | 実験手法 | ELECTRON MICROSCOPY (2.8 Å) | | 主引用文献 | Functionalized graphene-oxide grids enable high-resolution cryo-EM structures of the SNF2h-nucleosome complex without crosslinking.
Nat Commun, 15, 2024
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8VFY
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8VG1
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8VFZ
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1QE5
 | | PURINE NUCLEOSIDE PHOSPHORYLASE FROM CELLULOMONAS SP. IN COMPLEX WITH PHOSPHATE | | 分子名称: | CALCIUM ION, PENTOSYLTRANSFERASE, PHOSPHATE ION | | 著者 | Tebbe, J, Bzowska, A, Wielgus-Kutrowska, B, Schroeder, W, Kazimierczuk, Z, Shugar, D, Saenger, W, Koellner, G. | | 登録日 | 1999-07-13 | | 公開日 | 1999-12-12 | | 最終更新日 | 2023-08-16 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Crystal structure of the purine nucleoside phosphorylase (PNP) from Cellulomonas sp. and its implication for the mechanism of trimeric PNPs.
J.Mol.Biol., 294, 1999
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6JM9
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8YBK
 | | Cryo-EM structure of the human nucleosome containing the H3.1 E97K mutant | | 分子名称: | DNA (145-MER), Histone H2A type 1-B/E, Histone H2B type 1-J, ... | | 著者 | Kimura, T, Hirai, S, Kujirai, T, Ogasawara, M, Takizawa, Y, Kurumizaka, H. | | 登録日 | 2024-02-14 | | 公開日 | 2024-07-24 | | 最終更新日 | 2024-09-11 | | 実験手法 | ELECTRON MICROSCOPY (2.69 Å) | | 主引用文献 | Cryo-EM structure and biochemical analyses of the nucleosome containing the cancer-associated histone H3 mutation E97K.
Genes Cells, 29, 2024
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3H59
 | | Hepatitis C virus polymerase NS5B with thiazine inhibitor 2 | | 分子名称: | N-{3-[(5S)-5-(1,1-dimethylpropyl)-1-(4-fluoro-3-methylbenzyl)-4-hydroxy-2-oxo-2,5-dihydro-1H-pyrrol-3-yl]-1,1-dioxido-4H-1,4-benzothiazin-7-yl}methanesulfonamide, RNA-directed RNA polymerase | | 著者 | Harris, S.F, Ghate, M. | | 登録日 | 2009-04-21 | | 公開日 | 2009-09-08 | | 最終更新日 | 2024-11-06 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Non-nucleoside inhibitors of HCV polymerase NS5B. Part 3: synthesis and optimization studies of benzothiazine-substituted tetramic acids
Bioorg.Med.Chem.Lett., 19, 2009
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3NM6
 | | Helicobacter pylori MTAN complexed with adenine and tris | | 分子名称: | 1,2-ETHANEDIOL, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ADENINE, ... | | 著者 | Ronning, D.R, Iacopelli, N.M. | | 登録日 | 2010-06-21 | | 公開日 | 2010-11-24 | | 最終更新日 | 2023-12-27 | | 実験手法 | X-RAY DIFFRACTION (1.602 Å) | | 主引用文献 | Enzyme-ligand interactions that drive active site rearrangements in the Helicobacter pylori 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase.
Protein Sci., 19, 2010
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3NM5
 | | Helicobacter pylori MTAN complexed with Formycin A | | 分子名称: | (1S)-1-(7-amino-1H-pyrazolo[4,3-d]pyrimidin-3-yl)-1,4-anhydro-D-ribitol, MTA/SAH nucleosidase | | 著者 | Ronning, D.R, Iacopelli, N.M. | | 登録日 | 2010-06-21 | | 公開日 | 2010-11-24 | | 最終更新日 | 2023-12-27 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Enzyme-ligand interactions that drive active site rearrangements in the Helicobacter pylori 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase.
Protein Sci., 19, 2010
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6KE9
 | | The Human Telomeric Nucleosome Displays Distinct Structural and Dynamic Properties | | 分子名称: | Histone H2A type 1-B/E, Histone H2B type 1-K, Histone H3.1, ... | | 著者 | Soman, A, Liew, C.W, Teo, H.L, Berezhnoy, N, Korolev, N, Rhodes, D, Nordenskiold, L. | | 登録日 | 2019-07-04 | | 公開日 | 2020-04-22 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (2.22 Å) | | 主引用文献 | The human telomeric nucleosome displays distinct structural and dynamic properties.
Nucleic Acids Res., 48, 2020
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3NM4
 | | Helicobacter pylori MTAN | | 分子名称: | 1,2-ETHANEDIOL, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, MTA/SAH nucleosidase | | 著者 | Ronning, D.R, Iacopelli, N.M. | | 登録日 | 2010-06-21 | | 公開日 | 2010-11-24 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | | 主引用文献 | Enzyme-ligand interactions that drive active site rearrangements in the Helicobacter pylori 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase.
Protein Sci., 19, 2010
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3K8Q
 | | Crystal structure of human purine nucleoside phosphorylase in complex with SerMe-Immucillin H | | 分子名称: | 7-({[2-hydroxy-1-(hydroxymethyl)ethyl]amino}methyl)-3,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one, PHOSPHATE ION, Purine nucleoside phosphorylase | | 著者 | Ho, M, Almo, S.C, Scharmm, V.L. | | 登録日 | 2009-10-14 | | 公開日 | 2010-03-02 | | 最終更新日 | 2024-02-21 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Crystal structure of human nucleoside phosphorylase in complex with SerMe-ImmH
Proc.Natl.Acad.Sci.USA, 2010
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