PDB: 10530 件ウェブページステータス検索Chemie searchBIRD

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8XGT	Crystal structure of human secretory glutaminyl cyclase in complex with (Z)-3-((1H-benzo[d]imidazol-5-yl)methylene)-4-hydroxyindolin-2-one 分子名称: (3~{Z})-3-(1~{H}-benzimidazol-5-ylmethylidene)-4-oxidanyl-1~{H}-indol-2-one, Glutaminyl-peptide cyclotransferase, ZINC ION 著者 Li, G.-B, Wang, X.-Y. 登録日 2023-12-15 公開日 2024-06-12 最終更新日 2024-06-26 実験手法 X-RAY DIFFRACTION (2.813 Å) 主引用文献 X-ray Structure-Guided Discovery of a Potent Benzimidazole Glutaminyl Cyclase Inhibitor That Shows Activity in a Parkinson's Disease Mouse Model. J.Med.Chem., 67, 2024
8XBS	C. elegans apo-SID1 structure 分子名称: (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... 著者 Gong, D.S. 登録日 2023-12-07 公開日 2024-06-05 最終更新日 2024-07-03 実験手法 ELECTRON MICROSCOPY (2.21 Å) 主引用文献 Structural basis for double-stranded RNA recognition by SID1. Nucleic Acids Res., 52, 2024
9LDB	DESIGN AND SYNTHESIS OF NEW ENZYMES BASED ON THE LACTATE DEHYDROGENASE FRAMEWORK 分子名称: LACTATE DEHYDROGENASE, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, OXAMIC ACID, ... 著者 Dunn, C.R, Holbrook, J.J, Muirhead, H. 登録日 1991-11-26 公開日 1993-10-31 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Design and synthesis of new enzymes based on the lactate dehydrogenase framework. Philos.Trans.R.Soc.London,Ser.B, 332, 1991
9LDT	DESIGN AND SYNTHESIS OF NEW ENZYMES BASED ON THE LACTATE DEHYDROGENASE FRAMEWORK 分子名称: LACTATE DEHYDROGENASE, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, OXAMIC ACID, ... 著者 Dunn, C.R, Holbrook, J.J, Muirhead, H. 登録日 1991-11-26 公開日 1993-10-31 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Design and synthesis of new enzymes based on the lactate dehydrogenase framework. Philos.Trans.R.Soc.London,Ser.B, 332, 1991
8XC1	C. elegans SID1 in complex with dsRNA 分子名称: (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... 著者 Gong, D.S. 登録日 2023-12-07 公開日 2024-06-05 最終更新日 2024-07-03 実験手法 ELECTRON MICROSCOPY (2.21 Å) 主引用文献 Structural basis for double-stranded RNA recognition by SID1. Nucleic Acids Res., 52, 2024
8XGB	Crystal structure of human secretory glutaminyl cyclase in complex with (S)-1-(1H-benzo[d]imidazol-5-yl)-5-(4-propoxyphenyl)imidazolidin-2-one 分子名称: (5~{S})-1-(3~{H}-benzimidazol-5-yl)-5-(4-propoxyphenyl)imidazolidin-2-one, Glutaminyl-peptide cyclotransferase, ZINC ION 著者 Li, G.-B, Wang, X.-Y. 登録日 2023-12-15 公開日 2024-06-12 最終更新日 2024-06-26 実験手法 X-RAY DIFFRACTION (3.24 Å) 主引用文献 X-ray Structure-Guided Discovery of a Potent Benzimidazole Glutaminyl Cyclase Inhibitor That Shows Activity in a Parkinson's Disease Mouse Model. J.Med.Chem., 67, 2024
8XGY	Crystal structure of human Golgi resident glutaminyl cyclase in complex with (R,Z)-3-((1H-benzo[d]imidazol-5-yl)methylene)-4-((1-acetylpyrrolidin-3-yl)oxy)indolin-2-one 分子名称: (3~{Z})-3-(1~{H}-benzimidazol-5-ylmethylidene)-4-[(3~{R})-1-ethanoylpyrrolidin-3-yl]oxy-1~{H}-indol-2-one, Glutaminyl-peptide cyclotransferase, ZINC ION 著者 Li, G.-B, Wang, X.-Y. 登録日 2023-12-16 公開日 2024-06-12 最終更新日 2024-06-26 実験手法 X-RAY DIFFRACTION (2.81 Å) 主引用文献 X-ray Structure-Guided Discovery of a Potent Benzimidazole Glutaminyl Cyclase Inhibitor That Shows Activity in a Parkinson's Disease Mouse Model. J.Med.Chem., 67, 2024
7QTT	Structural organization of a late activated human spliceosome (Baqr, core region) 分子名称: 116 kDa U5 small nuclear ribonucleoprotein component, BUD13 homolog, Cell division cycle 5-like protein, ... 著者 Cretu, C, Pena, V. 登録日 2022-01-15 公開日 2023-05-10 最終更新日 2023-06-14 実験手法 ELECTRON MICROSCOPY (3.1 Å) 主引用文献 Structural basis of catalytic activation in human splicing. Nature, 617, 2023
3CZ2	Dimeric crystal structure of a pheromone binding protein from Apis mellifera at pH 7.0 分子名称: CHLORIDE ION, Pheromone-binding protein ASP1 著者 Pesenti, M.E, Spinelli, S, Bezirard, V, Briand, L, Pernollet, J.C, Tegoni, M, Cambillau, C. 登録日 2008-04-27 公開日 2009-04-28 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Queen bee pheromone binding protein pH-induced domain swapping favors pheromone release J.Mol.Biol., 390, 2009
4U28	Crystal structure of apo Phosphoribosyl isomerase A from Streptomyces sviceus ATCC 29083 分子名称: PHOSPHATE ION, Phosphoribosyl isomerase A 著者 Chang, C, Verduzco-Castro, E.A, Endres, M, Barona-Gomez, F, Joachimiak, A, Midwest Center for Structural Genomics (MCSG) 登録日 2014-07-16 公開日 2014-07-30 最終更新日 2023-12-27 実験手法 X-RAY DIFFRACTION (1.33 Å) 主引用文献 Co-occurrence of analogous enzymes determines evolution of a novel ( beta alpha )8-isomerase sub-family after non-conserved mutations in flexible loop. Biochem. J., 473, 2016
4U3B	LpxC from A.Aaeolicus in complex with the MMP inhibitor 4-[[4-(4-chlorophenoxy)phenyl]sulfanylmethyl]tetrahydropyran-4-carbohydroxamic acid - compound 2 分子名称: 4-({[4-(4-chlorophenoxy)phenyl]sulfanyl}methyl)-N-hydroxytetrahydro-2H-pyran-4-carboxamide, CHLORIDE ION, IMIDAZOLE, ... 著者 Olivier, N.B. 登録日 2014-07-19 公開日 2014-10-01 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (1.34 Å) 主引用文献 Synthesis, Structure, and SAR of Tetrahydropyran-Based LpxC Inhibitors. Acs Med.Chem.Lett., 5, 2014
7R1U	Crystal structure of SARS-CoV-2 nsp10/nsp16 in complex with the WZ16 inhibitor 分子名称: (2S,5S)-2,6-diamino-5-{[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl}hexanoic acid, 2'-O-methyltransferase nsp16, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, ... 著者 Klima, M, Boura, E, Li, F, Yazdi, A.K, Vedadi, M. 登録日 2022-02-03 公開日 2022-06-29 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Crystal structure of SARS-CoV-2 nsp10-nsp16 in complex with small molecule inhibitors, SS148 and WZ16. Protein Sci., 31, 2022
7R1T	Crystal structure of SARS-CoV-2 nsp10/nsp16 in complex with the SS148 inhibitor 分子名称: (2~{S})-2-azanyl-4-[[(2~{S},3~{S},4~{R},5~{R})-5-(4-azanyl-5-cyano-pyrrolo[2,3-d]pyrimidin-7-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methylsulfanyl]butanoic acid, 2'-O-methyltransferase nsp16, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, ... 著者 Klima, M, Boura, E, Li, F, Yazdi, A.K, Vedadi, M. 登録日 2022-02-03 公開日 2022-06-29 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Crystal structure of SARS-CoV-2 nsp10-nsp16 in complex with small molecule inhibitors, SS148 and WZ16. Protein Sci., 31, 2022
7R9X	Crystal structure of a dehydrating condensation domain, AmbE-CmodAA, involved in nonribosomal peptide synthesis 分子名称: AmbE, IODIDE ION, SODIUM ION 著者 Fortinez, C.M, Schmeing, T.M. 登録日 2021-06-29 公開日 2022-07-13 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.14 Å) 主引用文献 Structure and Function of a Dehydrating Condensation Domain in Nonribosomal Peptide Biosynthesis. J.Am.Chem.Soc., 144, 2022
4U3D	LpxC from A.Aaeolicus in complex with 4-[[4-[2-[4-(morpholinomethyl)phenyl]ethynyl]phenoxy]methyl]tetrahydropyran-4-carbohydroxamic acid (compound 9) 分子名称: CHLORIDE ION, IMIDAZOLE, N-hydroxy-4-[(4-{[4-(morpholin-4-ylmethyl)phenyl]ethynyl}phenoxy)methyl]tetrahydro-2H-pyran-4-carboxamide, ... 著者 Olivier, N.B. 登録日 2014-07-19 公開日 2014-10-01 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (1.25 Å) 主引用文献 Synthesis, Structure, and SAR of Tetrahydropyran-Based LpxC Inhibitors. Acs Med.Chem.Lett., 5, 2014
4TX9	Crystal structure of HisAp from Streptomyces sviceus with degraded ProFAR 分子名称: AMINOIMIDAZOLE 4-CARBOXAMIDE RIBONUCLEOTIDE, Phosphoribosyl isomerase A, SULFATE ION 著者 Michalska, K, Verduzco-Castro, E.A, Endres, M, Barona-Gomez, F, Joachimiak, A, Midwest Center for Structural Genomics (MCSG) 登録日 2014-07-02 公開日 2014-08-06 最終更新日 2023-12-27 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 Co-occurrence of analogous enzymes determines evolution of a novel ( beta alpha )8-isomerase sub-family after non-conserved mutations in flexible loop. Biochem. J., 473, 2016
7RW2	Cryo-EM structure of NTD-directed neutralizing antibody 5-7 in complex with prefusion SARS-CoV-2 spike glycoprotein 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 5-7 heavy chain, ... 著者 Cerutti, G, Shapiro, L. 登録日 2021-08-19 公開日 2021-09-01 最終更新日 2022-11-30 実験手法 ELECTRON MICROSCOPY (3.5 Å) 主引用文献 Neutralizing antibody 5-7 defines a distinct site of vulnerability in SARS-CoV-2 spike N-terminal domain. Cell Rep, 37, 2021
4U9B	Crystal structure of an H-NOX protein from S. oneidensis in the Fe(II)NO ligation state 分子名称: GLYCEROL, NITRIC OXIDE, NO-binding heme-dependent sensor protein, ... 著者 Herzik Jr, M.A, Jonnalagadda, R, Kuriyan, J, Marletta, M.A. 登録日 2014-08-05 公開日 2014-10-01 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (1.65 Å) 主引用文献 Structural insights into the role of iron-histidine bond cleavage in nitric oxide-induced activation of H-NOX gas sensor proteins. Proc.Natl.Acad.Sci.USA, 111, 2014
4UUK	Human dynamin 1 K44A superconstricted polymer stabilized with GTP strand 2 分子名称: DYNAMIN-1 著者 Sundborger, A.C, Fang, S, Heymann, J.A, Ray, P, Chappie, J.S, Hinshaw, J.E. 登録日 2014-07-29 公開日 2014-08-27 最終更新日 2024-05-08 実験手法 ELECTRON MICROSCOPY (12.5 Å) 主引用文献 A Dynamin Mutant Defines a Superconstricted Prefission State. Cell Rep., 8, 2014
4W9T	Crystal structure of HisAP from Streptomyces sp. Mg1 分子名称: Phosphoribosyl isomerase A, SULFATE ION 著者 MICHALSKA, K, VERDUZCO-CASTRO, E.A, ENDRES, M, BARONA-GOMEZ, F, JOACHIMIAK, A, Midwest Center for Structural Genomics (MCSG) 登録日 2014-08-27 公開日 2014-09-10 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (1.57 Å) 主引用文献 Co-occurrence of analogous enzymes determines evolution of a novel ( beta alpha )8-isomerase sub-family after non-conserved mutations in flexible loop. Biochem. J., 473, 2016
7SJ0	Antibody A7V3 bound to N-terminal domain of the spike 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, A7V3 Fab heavy chain, A7V3 Fab light chain, ... 著者 Hsieh, C.-L, McLellan, J.S. 登録日 2021-10-15 公開日 2022-11-16 実験手法 ELECTRON MICROSCOPY (3.36 Å) 主引用文献 Antibody A7V3 bound to N-terminal domain of the spike To Be Published
7TAA	FAMILY 13 ALPHA AMYLASE IN COMPLEX WITH ACARBOSE 分子名称: CALCIUM ION, MODIFIED ACARBOSE HEXASACCHARIDE, TAKA AMYLASE 著者 Davies, G.J, Brzozowski, A.M. 登録日 1997-10-06 公開日 1998-11-25 最終更新日 2011-07-13 実験手法 X-RAY DIFFRACTION (1.98 Å) 主引用文献 Structure of the Aspergillus oryzae alpha-amylase complexed with the inhibitor acarbose at 2.0 A resolution. Biochemistry, 36, 1997
7T5F	Botulinum neurotoxin Type B Light Chain complexed with nanobodies JLJ-G3 and JNE-B10 分子名称: Botulinum neurotoxin type B, IODIDE ION, JLJ-G3, ... 著者 Jin, R, Lam, K.-H. 登録日 2021-12-12 公開日 2021-12-29 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Probing the structure and function of the protease domain of botulinum neurotoxins using single-domain antibodies. Plos Pathog., 18, 2022
7SXI	Solution Structure of Sds3 Capped Tudor Domain 分子名称: Sin3 histone deacetylase corepressor complex component SDS3 著者 Marcum, R.D, Radhakrishnan, I. 登録日 2021-11-23 公開日 2022-01-19 最終更新日 2024-05-15 実験手法 SOLUTION NMR 主引用文献 A capped Tudor domain within a core subunit of the Sin3L/Rpd3L histone deacetylase complex binds to nucleic acid G-quadruplexes. J.Biol.Chem., 298, 2022
7ROQ	Alternative Structure of Human ABCA1 分子名称: (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... 著者 Aller, S.G. 登録日 2021-08-01 公開日 2022-01-19 実験手法 ELECTRON MICROSCOPY (4.1 Å) 主引用文献 Refined ABCA1 with Domain-swapped Regulatory Domains Plos One, 2022

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