PDB: 36939 件ウェブページステータス検索Chemie searchBIRD

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7JUT	Crystal Structure of KSR2:MEK1 in complex with ANP-PNP, and allosteric MEK inhibitor Selumetinib 分子名称: 5-[(4-bromo-2-chlorophenyl)amino]-4-fluoro-N-(2-hydroxyethoxy)-1-methyl-1H-benzimidazole-6-carboxamide, Dual specificity mitogen-activated protein kinase kinase 1, Kinase suppressor of Ras 2, ... 著者 Khan, Z.M, Dar, A.C. 登録日 2020-08-20 公開日 2020-09-30 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (3.09 Å) 主引用文献 Structural basis for the action of the drug trametinib at KSR-bound MEK. Nature, 588, 2020
7JUV	Crystal Structure of KSR2:MEK1 in complex with AMP-PNP, and allosteric MEK inhibitor APS-9-95-1 分子名称: Dual specificity mitogen-activated protein kinase kinase 1, Kinase suppressor of Ras 2, MAGNESIUM ION, ... 著者 Khan, Z.M, Dar, A.C, Scopton, A.P. 登録日 2020-08-20 公開日 2020-09-30 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (3.36 Å) 主引用文献 Structural basis for the action of the drug trametinib at KSR-bound MEK. Nature, 588, 2020
7JUS	Crystal Structure of KSR2:MEK1 in complex with AMP-PNP, and allosteric MEK inhibitor Cobimetinib 分子名称: Cobimetinib, Dual specificity mitogen-activated protein kinase kinase 1, Kinase suppressor of Ras 2, ... 著者 Khan, Z.M, Dar, A.C. 登録日 2020-08-20 公開日 2020-09-30 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.99 Å) 主引用文献 Structural basis for the action of the drug trametinib at KSR-bound MEK. Nature, 588, 2020
7JV0	Crystal Structure of KSR1:MEK1 in complex with AMP-PNP, and allosteric MEK inhibitor PD0325901 分子名称: Dual specificity mitogen-activated protein kinase kinase 1, Kinase suppressor of Ras 1, MAGNESIUM ION, ... 著者 Khan, Z.M, Dar, A.C. 登録日 2020-08-20 公開日 2020-09-30 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (3.63 Å) 主引用文献 Structural basis for the action of the drug trametinib at KSR-bound MEK. Nature, 588, 2020
7A4V	Crystal structure of lid-truncated ADP-bound BiP in an oligomeric state 分子名称: ADENOSINE-5'-DIPHOSPHATE, Endoplasmic reticulum chaperone BiP, GLYCEROL, ... 著者 Perera, L.A, Ron, D. 登録日 2020-08-20 公開日 2020-12-16 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.94 Å) 主引用文献 Calcium depletion challenges endoplasmic reticulum proteostasis by destabilising BiP-substrate complexes. Elife, 9, 2020
7JUW	Crystal Structure of KSR1:MEK1 in complex with AMP-PNP 分子名称: Dual specificity mitogen-activated protein kinase kinase 1, Kinase suppressor of Ras 1, MAGNESIUM ION, ... 著者 Khan, Z.M, Dar, A.C. 登録日 2020-08-20 公開日 2020-09-30 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.88 Å) 主引用文献 Structural basis for the action of the drug trametinib at KSR-bound MEK. Nature, 588, 2020
7JV1	Crystal Structure of KSR1:MEK1 in complex with AMP-PNP, and allosteric MEK inhibitor APS-9-95-1 分子名称: Dual specificity mitogen-activated protein kinase kinase 1, Kinase suppressor of Ras 1, MAGNESIUM ION, ... 著者 Khan, Z.M, Dar, A.C, Scopton, A.P. 登録日 2020-08-20 公開日 2020-09-30 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (3.62 Å) 主引用文献 Structural basis for the action of the drug trametinib at KSR-bound MEK. Nature, 588, 2020
7JUQ	Crystal Structure of KSR2:MEK1 in complex with ADP 分子名称: ADENOSINE-5'-DIPHOSPHATE, Dual specificity mitogen-activated protein kinase kinase 1, Kinase suppressor of Ras 2, ... 著者 Khan, Z.M, Dar, A.C. 登録日 2020-08-20 公開日 2020-09-30 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (3.22 Å) 主引用文献 Structural basis for the action of the drug trametinib at KSR-bound MEK. Nature, 588, 2020
7JUR	Crystal Structure of KSR2:MEK1 in complex with AMP-PNP, and allosteric MEK inhibitor Trametinib 分子名称: Dual specificity mitogen-activated protein kinase kinase 1, Kinase suppressor of Ras 2, MAGNESIUM ION, ... 著者 Khan, Z.M, Dar, A.C. 登録日 2020-08-20 公開日 2020-09-30 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.82 Å) 主引用文献 Structural basis for the action of the drug trametinib at KSR-bound MEK. Nature, 588, 2020
7JUX	Crystal Structure of KSR1:MEK1 in complex with AMP-PNP, and allosteric MEK inhibitor Trametinib 分子名称: Dual specificity mitogen-activated protein kinase kinase 1, Kinase suppressor of Ras 1, MAGNESIUM ION, ... 著者 Khan, Z.M, Dar, A.C. 登録日 2020-08-20 公開日 2020-09-30 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (3.34 Å) 主引用文献 Structural basis for the action of the drug trametinib at KSR-bound MEK. Nature, 588, 2020
7A4U	Crystal structure of lid-truncated apo BiP in an oligomeric state 分子名称: Endoplasmic reticulum chaperone BiP, GLYCEROL 著者 Perera, L.A, Ron, D. 登録日 2020-08-20 公開日 2020-12-16 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.77 Å) 主引用文献 Calcium depletion challenges endoplasmic reticulum proteostasis by destabilising BiP-substrate complexes. Elife, 9, 2020
7JUY	Crystal Structure of KSR1:MEK1 in complex with AMP-PNP, and allosteric MEK inhibitor Cobimetinib 分子名称: Dual specificity mitogen-activated protein kinase kinase 1, Kinase suppressor of Ras 1, MAGNESIUM ION, ... 著者 Khan, Z.M, Dar, A.C. 登録日 2020-08-20 公開日 2020-10-07 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (3.096 Å) 主引用文献 Structural basis for the action of the drug trametinib at KSR-bound MEK. Nature, 588, 2020
7JV5	Cryo-EM structure of SKF-81297-bound dopamine receptor 1 in complex with Gs protein 分子名称: (1R)-6-chloro-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine-7,8-diol, CHOLESTEROL, D(1A) dopamine receptor, ... 著者 Zhuang, Y, Xu, P, Mao, C, Wang, L, Krumm, B, Zhou, X.E, Huang, S, Liu, H, Cheng, X, Huang, X.-P, Sheng, D.-D, Xu, T, Liu, Y.-F, Wang, Y, Guo, J, Jiang, Y, Jiang, H, Melcher, K, Roth, B.L, Zhang, Y, Zhang, C, Xu, H.E. 登録日 2020-08-20 公開日 2021-02-24 最終更新日 2021-03-03 実験手法 ELECTRON MICROSCOPY (3 Å) 主引用文献 Structural insights into the human D1 and D2 dopamine receptor signaling complexes. Cell, 184, 2021
7A45	CO-bound sperm whale myoglobin measured by serial femtosecond crystallography 分子名称: CARBON MONOXIDE, Myoglobin, PROTOPORPHYRIN IX CONTAINING FE, ... 著者 Mehrabi, P, Schulz, E.C, Buecker, R. 登録日 2020-08-19 公開日 2021-04-07 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.75 Å) 主引用文献 Serial femtosecond and serial synchrotron crystallography can yield data of equivalent quality: A systematic comparison. Sci Adv, 7, 2021
7A44	CO-bound sperm whale myoglobin measured by serial synchrotron crystallography 分子名称: CARBON MONOXIDE, Myoglobin, PROTOPORPHYRIN IX CONTAINING FE, ... 著者 Mehrabi, P, Schulz, E.C, Buecker, R. 登録日 2020-08-19 公開日 2021-04-07 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.75 Å) 主引用文献 Serial femtosecond and serial synchrotron crystallography can yield data of equivalent quality: A systematic comparison. Sci Adv, 7, 2021
7A47	KRASG12C GDP form in complex with Cpd4 分子名称: GUANOSINE-5'-DIPHOSPHATE, Isoform 2B of GTPase KRas, ~{N}-[3-bromanyl-2-(2-methylimidazol-1-yl)pyridin-4-yl]-3-[[3-bromanyl-2-(2-methylimidazol-1-yl)pyridin-4-yl]-propanoyl-amino]propanamide 著者 Bertrand, T, Steier, V. 登録日 2020-08-19 公開日 2021-10-13 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (2.16 Å) 主引用文献 KRAS G12C fragment screening renders new binding pockets. Small Gtpases, 13, 2022
7A46	small conductance mechanosensitive channel YbiO 分子名称: Putative transport protein 著者 Flegler, V.J, Rasmussen, A, Rao, S, Wu, N, Zenobi, R, Sansom, M.S.P, Hedrich, R, Rasmussen, T, Boettcher, B. 登録日 2020-08-19 公開日 2020-11-18 最終更新日 2024-05-01 実験手法 ELECTRON MICROSCOPY (3 Å) 主引用文献 The MscS-like channel YnaI has a gating mechanism based on flexible pore helices. Proc.Natl.Acad.Sci.USA, 117, 2020
7A4B	Crystal structure of human protein kinase CK2alpha (CSNK2A1 gene product) in complex with the ATP-competitive inhibitor 5,6-dibromo-1H-triazolo[4,5-b]pyridine 分子名称: 5,6-dibromo-1H-triazolo[4,5-b]pyridine, Casein kinase II subunit alpha, GLYCEROL, ... 著者 Niefind, K, Lindenblatt, D, Toelzer, C, Bretner, M, Chojnacki, K, Wielechowska, M, Winska, P. 登録日 2020-08-19 公開日 2020-12-09 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (2.06 Å) 主引用文献 Synthesis, biological properties and structural study of new halogenated azolo[4,5-b]pyridines as inhibitors of CK2 kinase. Bioorg.Chem., 106, 2021
7JUG	C-type carbohydrate-recognition domain 4 of the mannose receptor complexed with Man-alpha1-6Man 分子名称: CALCIUM ION, Macrophage mannose receptor 1, alpha-D-mannopyranose 著者 Weis, W.I, Feinberg, H. 登録日 2020-08-19 公開日 2021-02-03 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (1.4 Å) 主引用文献 Structural analysis of carbohydrate binding by the macrophage mannose receptor CD206. J.Biol.Chem., 296, 2021
7JUH	C-type carbohydrate-recognition domain 4 of the mannose receptor complexed with Man-alpha1-6Man 分子名称: CALCIUM ION, Macrophage mannose receptor 1, alpha-D-mannopyranose 著者 Weis, W.I, Feinberg, H. 登録日 2020-08-19 公開日 2021-02-03 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (1.4 Å) 主引用文献 Structural analysis of carbohydrate binding by the macrophage mannose receptor CD206. J.Biol.Chem., 296, 2021
7A49	Crystal structure of human protein kinase CK2alpha (CSNK2A1 gene product) in complex with the ATP-competitive inhibitor 6-bromo-5-chloro-1H-triazolo[4,5-b]pyridine 分子名称: 6-bromanyl-5-chloranyl-1~{H}-[1,2,3]triazolo[4,5-b]pyridine, Casein kinase II subunit alpha, SULFATE ION 著者 Niefind, K, Lindenblatt, D, Toelzer, C, Bretner, M, Chojnacki, K, Wielechowska, M, Winska, P. 登録日 2020-08-19 公開日 2020-12-09 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (2.03 Å) 主引用文献 Synthesis, biological properties and structural study of new halogenated azolo[4,5-b]pyridines as inhibitors of CK2 kinase. Bioorg.Chem., 106, 2021
7JU4	Radial spoke 2 stalk, IDAc, and N-DRC attached with doublet microtubule 分子名称: 28 kDa inner dynein arm light chain, axonemal, ADENOSINE-5'-TRIPHOSPHATE, ... 著者 Gui, M, Ma, M, Sze-Tu, E, Wang, X, Koh, F, Zhong, E, Berger, B, Davis, J, Dutcher, S, Zhang, R, Brown, A. 登録日 2020-08-19 公開日 2020-12-16 最終更新日 2024-03-06 実験手法 ELECTRON MICROSCOPY (3.4 Å) 主引用文献 Structures of radial spokes and associated complexes important for ciliary motility. Nat.Struct.Mol.Biol., 28, 2021
7JUB	C-type carbohydrate-recognition domain 4 of the mannose receptor complexed with methyl-mannoside 分子名称: CALCIUM ION, Macrophage mannose receptor 1, methyl alpha-D-mannopyranoside 著者 Weis, W.I, Feinberg, H. 登録日 2020-08-19 公開日 2021-02-03 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (1.2 Å) 主引用文献 Structural analysis of carbohydrate binding by the macrophage mannose receptor CD206. J.Biol.Chem., 296, 2021
7JUF	C-type carbohydrate-recognition domain 4 of the mannose receptor complexed with Man-alpha1-2Man 分子名称: CALCIUM ION, DI(HYDROXYETHYL)ETHER, Macrophage mannose receptor 1, ... 著者 Weis, W.I, Feinberg, H. 登録日 2020-08-19 公開日 2021-02-03 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (1.4 Å) 主引用文献 Structural analysis of carbohydrate binding by the macrophage mannose receptor CD206. J.Biol.Chem., 296, 2021
7A4C	Crystal structure of human protein kinase CK2alpha (CSNK2A1 gene product) in complex with the ATP-competitive inhibitor 5,6,7-tribromo-1H-triazolo[4,5-b]pyridine 分子名称: 5,6,7-tris(bromanyl)-1~{H}-[1,2,3]triazolo[4,5-b]pyridine, Casein kinase II subunit alpha, GLYCEROL, ... 著者 Niefind, K, Lindenblatt, D, Toelzer, C, Bretner, M, Chojnacki, K, Wielechowska, M, Winska, P. 登録日 2020-08-19 公開日 2020-12-09 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (2.502 Å) 主引用文献 Synthesis, biological properties and structural study of new halogenated azolo[4,5-b]pyridines as inhibitors of CK2 kinase. Bioorg.Chem., 106, 2021

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