7A49

Crystal structure of human protein kinase CK2alpha (CSNK2A1 gene product) in complex with the ATP-competitive inhibitor 6-bromo-5-chloro-1H-triazolo[4,5-b]pyridine

Summary for 7A49

• Entry DOI: 10.2210/pdb7a49/pdb
• Related: 7A1Z
• Descriptor: Casein kinase II subunit alpha, 6-bromanyl-5-chloranyl-1~{H}-[1,2,3]triazolo[4,5-b]pyridine, SULFATE ION, ... (4 entities in total)
• Functional Keywords: protein kinase ck2, casein kinase 2, atp-competitive inhibitor, transferase
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 81561.02

Authors

Niefind, K.,Lindenblatt, D.,Toelzer, C.,Bretner, M.,Chojnacki, K.,Wielechowska, M.,Winska, P. (deposition date: 2020-08-19, release date: 2020-12-09, Last modification date: 2024-01-31)

• Primary citation: Chojnacki, K.,Lindenblatt, D.,Winska, P.,Wielechowska, M.,Toelzer, C.,Niefind, K.,Bretner, M.; Synthesis, biological properties and structural study of new halogenated azolo[4,5-b]pyridines as inhibitors of CK2 kinase.; Bioorg.Chem., 106:104502-104502, 2021; PubMed: 33317841; DOI: 10.1016/j.bioorg.2020.104502

Experimental method

X-RAY DIFFRACTION (2.03 Å)